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pro vyhledávání: '"Anthony Panetta"'
Autor:
Sylvain Lefebvre, Silvana Leit, Alina Nicolescu, Marielle Fournel, Anthony Panetta, Jeffrey M. Besterman, Jubrail Rahil, Amal Wahhab, Anne-Marie Lemieux, Sukhdev Manku, Christiane R. Maroun, Yves Andre Chantigny, Theresa P. Yan, Robert Deziel, Zuomei Li, David Smil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:688-692
In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/II