Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anthony P. Schiavone"'
Autor:
Thomas E. Smithgall, Malcolm A. Meyn, Jiong Wu, Nathalie Fahey, Fadi A. Abdi, James M. Hochrein, Matthew B Wilson, Anthony P. Schiavone, John R. Engen
Publikováno v:
Journal of Biological Chemistry. 281:30907-30916
Bcr-Abl is the oncogenic protein-tyrosine kinase responsible for chronic myelogenous leukemia. Recently, we observed that inhibition of myeloid Src family kinase activity (e.g. Hck, Lyn, and Fyn) induces growth arrest and apoptosis in Bcr-Abl-transfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536f012e0c4eab006efe32eefc15e519
https://doi.org/10.1074/jbc.m605902200
https://doi.org/10.1074/jbc.m605902200
Autor:
John R. Engen, James M. Hochrein, Thomas E. Smithgall, Ronald P. Trible, Edwina C. Lerner, Anthony P. Schiavone
Publikováno v:
Journal of Biological Chemistry. 280:40832-40837
Src family protein-tyrosine kinases are regulated by intramolecular binding of the SH2 domain to the C-terminal tail and association of the SH3 domain with the SH2 kinase-linker. The presence of two regulatory interactions raises the question of whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8b2121d61299d2bcecab6f84db3912
https://doi.org/10.1074/jbc.m508782200
https://doi.org/10.1074/jbc.m508782200
Publikováno v:
Journal of Biological Chemistry. 277:45680-45687
STAT3 is a member of a family of transcription factors with Src homology 2 (SH2) domains that are activated by tyrosine phosphorylation in response to a wide variety of cytokines and growth factors. In this study, we investigated the mechanism of STA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f3041e4a4cf3e10e55fedd532aafa7
https://doi.org/10.1074/jbc.m204255200
https://doi.org/10.1074/jbc.m204255200
Publikováno v:
Biochemistry. 45(25)
The Nef protein from human or simian immunodeficiency virus enhances viral replication, downregulates immune cell receptors, and activates multiple host cell signaling pathways. Conformational information about full-length Nef has been difficult to o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874d997d04d768582af147d32c5014e8
https://pubmed.ncbi.nlm.nih.gov/16784224
https://pubmed.ncbi.nlm.nih.gov/16784224
Autor:
Thomas E. Wales, John R. Engen, Edwina C. Lerner, James M. Hochrein, Thomas E. Smithgall, Anthony P. Schiavone
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4db5e4344b553ba79f9c326bf9a054
https://doi.org/10.1096/fasebj.20.4.a490-c
https://doi.org/10.1096/fasebj.20.4.a490-c
Autor:
John R. Engen, Anthony P. Schiavone, Edwina C. Lerner, James M. Hochrein, Thomas E. Smithgall
Publikováno v:
Protein science : a publication of the Protein Society. 15(1)
The ability of proteins to regulate their own enzymatic activity can be facilitated by changes in structure or protein dynamics in response to external regulators. Because many proteins contain SH2 and SH3 domains, transmission of information between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8719934c3280b9c7ee5aa4c6d402c0df
https://pubmed.ncbi.nlm.nih.gov/16322569
https://pubmed.ncbi.nlm.nih.gov/16322569
The c-fes locus encodes a 93-kDa non-receptor protein tyrosine kinase (Fes) that regulates the growth and differentiation of hematopoietic and vascular endothelial cells. Unique to Fes is a long N-terminal sequence with two regions of strong homology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1ae2a54ea2cf124887cebd6ceb725b
https://europepmc.org/articles/PMC87334/
https://europepmc.org/articles/PMC87334/
