Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anthony P. Popkie"'
Autor:
Jie Li, Zhongqiu Zhang, Zunyan Dai, Anthony P. Popkie, Christoph Plass, Carl Morrison, Yian Wang, Ming You
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 4, Pp 362-366 (2003)
In the present studies, we investigated the correlation between RASSF1A promoter methylation status and Kras2 mutations in 65 primary non small cell lung cancer (NSCLC) including 33 adenocarcinomas, 12 large cell carcinomas, and 20 squamous cell carc
Externí odkaz:
https://doaj.org/article/edab9ea4c31746c099dfa54e9a582d32
Publikováno v:
Current Pathobiology Reports. 2:27-32
The remarkable molecular diversity of breast cancers affects therapeutic options and clinical outcome for patients. Understanding the cell of origin and the factors that impact stem cell differentiation and proliferation are crucial aspects for the d
Autor:
Sigrid Eckardt, Leigh C. Zeidner, Joanna Groden, Bruce J. Aronow, Peter White, K. John McLaughlin, Anthony P. Popkie, Ashley M. Albrecht, David E. Newsom, Christopher J. Phiel, Anthony D'Ippolito, Bradley W. Doble
Publikováno v:
Journal of Biological Chemistry. 285:41337-41347
Glycogen synthase kinase-3 (Gsk-3) isoforms, Gsk-3α and Gsk-3β, are constitutively active, largely inhibitory kinases involved in signal transduction. Underscoring their biological significance, altered Gsk-3 activity has been implicated in diabete
Autor:
Suranjana Goswami, Douglas Kline, Christopher J. Phiel, Rahul Bhattacharjee, Srinivasan Vijayaraghavan, Anthony P. Popkie
Publikováno v:
The FASEB Journal. 29
The signaling enzyme glycogen synthase kinase 3 exists as two isoforms – GSK3A and GSK3B. GSK3 is part of key signaling pathways in several cells and tissues. We have previously shown that both iso...
Autor:
Anthony D'Ippolito, Bradley W. Doble, Leigh C. Zeidner, George Marnellos, Kelsie J. Faulds, Gavin Meredith, Logan Hostetter, Thomas H. Arnold, Yulei Wang, Christopher M Adams, Miroslav Dudas, Christopher J. Phiel, Anthony P. Popkie
Publikováno v:
Molecular Biology of the Cell
A genome-wide analysis is given of DNA methylation in mouse embryonic stem cells in which both Gsk-3α and Gsk-3β have been genetically deleted. DNA methylation patterns are compared to those of wild-type cells. More than 75% of known imprinted loci
Autor:
Douglas Kline, Suranjana Goswami, Rahul Bhattacharjee, Srinivasan Vijayaraghavan, Anthony P. Popkie, Christopher J. Phiel, Tejasvi Dudiki
The signaling enzyme glycogen synthase kinase 3 (GSK3) exists as two isoforms—GSK3A and GSK3B. Protein phosphorylation by GSK3 has important signaling roles in several cells. In our past work, we found that both isoforms of GSK3 are present in mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2f40741575110a3fdaf8373afb5f0b
https://europepmc.org/articles/PMC4358024/
https://europepmc.org/articles/PMC4358024/
While a small portion of the human genome is composed of protein-coding genes, a far greater portion is now known to be transcribed into noncoding RNAs (ncRNAs). Noncoding RNAs have many regulatory functions, including those of shaping and maintainin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad755a9e5caf14568e843ccdbbb0452
https://doi.org/10.1016/b978-0-12-420135-4.00004-8
https://doi.org/10.1016/b978-0-12-420135-4.00004-8
Autor:
Zunyan Dai, Thomas J. Rosol, Gloria A. Niehans, Carl Morrison, Gustavo Leone, Wei-Guo Zhu, Christoph Plass, Cynthia Timmers, Sarah H. Tannehill-Gregg, Herbert Auer, Robert A. Kratzke, Wolfgang Sommergruber, Gregory A. Otterson, Anthony P. Popkie, Stefan Amatschek, Aparna Raval
Publikováno v:
Oncogene. 23:3521-3529
Bone morphogenetic protein 3B (BMP3B) is a member of the TGF-beta superfamily. The BMP3B promoter sequence was previously identified as a target for aberrant DNA methylation in non-small-cell lung cancer (NSCLC). Aberrant DNA hypermethylation in the
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1350:345-358
Eukaryotic elongation factor 1A (eEF1A, formerly eEF-1 alpha) carries aminoacyl-tRNAs into the A-site of the ribosome in a GTP-dependent manner. In order to probe the structure/function relationships of eEF1A, we have generated site-directed mutants
Publikováno v:
Cancer Research. 76:3621-3621
Cancer is a genetic disease, caused by a variety of alterations to a cell's genome. One specific type of alteration associated with cancer is point mutations, and Next-generation sequencing (NGS) is a key tool to identify those mutations. Unlike inhe