Medical treatment of Cushing's disease: Overview and recent findings

Autor: Stephanie Smooke Praw, Anthony P Heaney

Publikováno v: International Journal of General Medicine, Vol 2009, Iss default, Pp 209-217 (2009)

Stephanie Smooke Praw1, Anthony P Heaney1,21Department of Medicine, 2Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAAbstract: Cushing's disease, due to pituitary adrenocorticotropic hormone (ACTH) hypersecret

Externí odkaz: https://doaj.org/article/460a8f77a04246b99a3759093a762c2b

Circulating FK506 binding protein 51 mRNA expression in patients with pituitary adenomas

Autor: Yingying Yang, Lilit Babayan, Argishty Mirzakhanian, Nvard Sisliyan, Dongyun Zhang, Carolina Hurtado, Abdul Zahid, Marvin Bergsneider, Won Kim, Marilene B. Wang, Anthony P. Heaney

Publikováno v: Heliyon, Vol 9, Iss 1, Pp e12678- (2023)

Background: FK506 binding protein 51 (FKBP5) is a co-chaperone regulator of the glucocorticoid receptor (GR). Recent studies have reported increased FKBP5 mRNA in the circulation from patients with Cushing disease (CD) which returned to comparable le

Externí odkaz: https://doaj.org/article/0dbd2adbafdd481d9beb37cd8707c55c

Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

Autor: Na Sun, Yi-Te Lee, Ryan Y. Zhang, Rueihung Kao, Pai-Chi Teng, Yingying Yang, Peng Yang, Jasmine J. Wang, Matthew Smalley, Pin-Jung Chen, Minhyung Kim, Shih-Jie Chou, Lirong Bao, Jing Wang, Xinyue Zhang, Dongping Qi, Juvelyn Palomique, Nicolas Nissen, Steven-Huy B. Han, Saeed Sadeghi, Richard S. Finn, Sammy Saab, Ronald W. Busuttil, Daniela Markovic, David Elashoff, Hsiao-hua Yu, Huiying Li, Anthony P. Heaney, Edwin Posadas, Sungyong You, Ju Dong Yang, Renjun Pei, Vatche G. Agopian, Hsian-Rong Tseng, Yazhen Zhu

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Extracellular vesicles (EVs) are present in circulation at relatively early stages of disease, providing potential opportunities for early cancer diagnosis. Here, the authors report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific E

Externí odkaz: https://doaj.org/article/7cae50dc76a9464fb0cb00c27a2f9b1f

A human ACTH-secreting corticotroph tumoroid model

Autor: Dongyun Zhang, Willy Hugo, Peter Redublo, Hui Miao, Marvin Bergsneider, Marilene B. Wang, Won Kim, William H. Yong, Anthony P. Heaney

Publikováno v: EBioMedicine, Vol 66, Iss , Pp 103294- (2021)

Background: Cushing disease (CD), although rare, is a life-threatening disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma, which leads to excess adrenal-derived cortisol. Efficacious and safe medical therapies that c

Externí odkaz: https://doaj.org/article/2601596e7f584ac4b65e0bb080bf7b79

Levoketoconazole treatment in endogenous Cushing's syndrome: extended evaluation of clinical, biochemical, and radiologic outcomes

Autor: Maria Fleseriu, Richard J Auchus, Yona Greenman, Sabina Zacharieva, Eliza B Geer, Roberto Salvatori, Rosario Pivonello, Ulla Feldt-Rasmussen, Laurence Kennedy, Michael Buchfelder, Beverly M K Biller, Fredric Cohen, Anthony P Heaney

Publikováno v: Fleseriu, M, Auchus, R J, Greenman, Y, Zacharieva, S, Geer, E B, Salvatori, R, Pivonello, R, Feldt-Rasmussen, U, Kennedy, L, Buchfelder, M, Biller, B M K, Cohen, F & Heaney, A P 2022, ' Levoketoconazole treatment in endogenous Cushing’s syndrome : extended evaluation of clinical, biochemical, and radiologic outcomes ', European Journal of Endocrinology, vol. 187, no. 6, pp. 859-871 . https://doi.org/10.1530/EJE-22-0506

Objective This extended evaluation (EE) of the SONICS study assessed the effects of levoketoconazole for an additional 6 months following open-label, 6-month maintenance treatment in endogenous Cushing's syndrome. Design/Methods SONICS included dose-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6abc5f0728978ace9e840e12e945175
https://doi.org/10.1530/eje-22-0506