Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Anthony O. Gramolini"'
Autor:
Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrop
Externí odkaz:
https://doaj.org/article/aafde2c6ca28412ea8f19a14b47c1f34
Autor:
Veera Ganesh Yerra, Sri Nagarjun Batchu, Harmandeep Kaur, MD Golam Kabir, Youan Liu, Suzanne L. Advani, Duc Tin Tran, Shadi Sadeghian, Phelopater Sedrak, Filio Billia, Uros Kuzmanov, Anthony O. Gramolini, Deema O. Qasrawi, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kim A. Connelly, Andrew Advani
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Inflammation promotes adverse ventricular remodeling, a common antecedent of heart failure. Here, we set out to determine how inflammatory cells affect cardiomyocytes in the remodeling heart. Pathogenic cardiac macrophages induced an IFN response in
Externí odkaz:
https://doaj.org/article/0c5911e4a2bf433aac0c14bc3122354f
Autor:
Allen C.T. Teng, Marjan Tavassoli, Suja Shrestha, Ryan M. Marks, Meghan J. McFadden, Sonia L. Evagelou, Kyle Lindsay, Ava Vandenbelt, Wenping Li, Evgueni Ivakine, Ronald Cohn, J. Paul Santerre, Anthony O. Gramolini
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101933- (2023)
Summary: Here, we describe a protocol for purifying functional clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) from Staphylococcus aureus within 24 h and over 90% purity. SaCas9 purification begins with
Externí odkaz:
https://doaj.org/article/d1573157b4e54e4c84f54302f66cee69
Autor:
Jeremy A. Antonyshyn, Vienna Mazzoli, Meghan J. McFadden, Anthony O. Gramolini, Stefan O. P. Hofer, Craig A. Simmons, J. Paul Santerre
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Antonyshyn et al. establish a methodology for acquiring human adipose tissue-derived microvascular endothelial cells that can be readily applied in future vascular tissue engineering applications. The authors developed strategies to mitigate the non-
Externí odkaz:
https://doaj.org/article/1f3a0bde7e2840cba941ac6669c4daa6
Autor:
Jeremy A. Antonyshyn, Meghan J. McFadden, Anthony O. Gramolini, Stefan O.P. Hofer, J. Paul Santerre
Publikováno v:
Biomaterials and Biosystems, Vol 6, Iss , Pp 100049- (2022)
Adipose tissue is an abundant, accessible, and uniquely dispensable source of cells for vascular tissue engineering. Despite its intrinsic endothelial cells, considerable effort is directed at deriving endothelium from its resident stem and progenito
Externí odkaz:
https://doaj.org/article/b8b52c6428d748dba069a464883c719f
Autor:
Shin-Haw Lee, Sina Hadipour-Lakmehsari, Harsha R. Murthy, Natalie Gibb, Tetsuaki Miyake, Allen C. T. Teng, Jake Cosme, Jessica C. Yu, Mark Moon, SangHyun Lim, Victoria Wong, Peter Liu, Filio Billia, Rodrigo Fernandez-Gonzalez, Igor Stagljar, Parveen Sharma, Thomas Kislinger, Ian C. Scott, Anthony O. Gramolini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractili
Externí odkaz:
https://doaj.org/article/9f62361bf8a34f7da79df62e9762126b
Autor:
Amanda L. Mohabeer, Jeffrey T. Kroetsch, Meghan McFadden, Negin Khosraviani, Thomas J. Broekelmann, Guangpei Hou, Hangjun Zhang, Yu-Qing Zhou, Minyao Wang, Anthony O. Gramolini, Robert P. Mecham, Scott P. Heximer, Steffen-Sebastian Bolz, Michelle P. Bendeck
Publikováno v:
Matrix Biology Plus, Vol 12, Iss , Pp 100085- (2021)
Arterial stiffening is a significant predictor of cardiovascular disease development and mortality. In elastic arteries, stiffening refers to the loss and fragmentation of elastic fibers, with a progressive increase in collagen fibers. Type VIII coll
Externí odkaz:
https://doaj.org/article/1c0e6c4c6c564815be877bd0f3ad21d7
Publikováno v:
Cell Stress, Vol 4, Iss 6, Pp 151-153 (2020)
The sarco-endoplasmic reticulum (SR/ER) is the largest membrane-bound organelle in eukaryotic cells and plays important roles in essential cellular processes, and in development and progression of many cardiac diseases. However, many aspects of its s
Externí odkaz:
https://doaj.org/article/e0c3deadf76f400ea614fae853ea7c02
Autor:
Jeremy A. Antonyshyn, Meghan J. McFadden, Anthony O. Gramolini, Stefan O.P. Hofer, J. Paul Santerre
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 1, Pp 35-45 (2019)
Abstract Considerable effort has been directed toward deriving endothelial cells (ECs) from adipose‐derived mesenchymal stem cells (ASCs) since 2004, when it was first suggested that ECs and adipocytes share a common progenitor. While the capacity
Externí odkaz:
https://doaj.org/article/553cf1ba4bdb4976b6ebecad96d025f2
Autor:
Farigol Hakem Zadeh, Allen C. T. Teng, Uros Kuzmanov, Paige J. Chambers, Allan R. Tupling, Anthony O. Gramolini
Publikováno v:
Physiological Reports, Vol 7, Iss 14, Pp n/a-n/a (2019)
Abstract Phospholamban (PLN) is an important Ca2+ modulator at the sarcoplasmic reticulum (SR) of striated muscles. It physically interacts and inhibits sarcoplasmic reticulum Ca2+ ATPase (SERCA2) function, whereas a protein kinase A (PKA)‐dependen
Externí odkaz:
https://doaj.org/article/fddcae4ea88746798cb6cd54d91145c2