Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Anthony N. Hodder"'
Autor:
Justin A. Boddey, Matthew T. O’Neill, Sash Lopaticki, Teresa G. Carvalho, Anthony N. Hodder, Thomas Nebl, Stephan Wawra, Pieter van West, Zeinab Ebrahimzadeh, Dave Richard, Sven Flemming, Tobias Spielmann, Jude Przyborski, Jeff J. Babon, Alan F. Cowman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via clea
Externí odkaz:
https://doaj.org/article/9c31a074ac774adfad666d242b4d3b61
Autor:
Lachlan W. Richardson, Trent D. Ashton, Madeline G. Dans, Nghi Nguyen, Paola Favuzza, Tony Triglia, Anthony N. Hodder, Anna Ngo, Kate E. Jarman, Alan F. Cowman, Brad E. Sleebs
Publikováno v:
ChemMedChem. 17(18)
Plasmepsin X (PMX) is an aspartyl protease that processes proteins essential for Plasmodium parasites to invade and egress from host erythrocytes during the symptomatic asexual stage of malaria. PMX substrates possess a conserved cleavage region deno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b486f854b3a922119d8a9f79226a6b71
https://pubmed.ncbi.nlm.nih.gov/35906744
https://pubmed.ncbi.nlm.nih.gov/35906744
Autor:
Anthony N. Hodder, Janni Christensen, Stephen Scally, Tony Triglia, Anna Ngo, Richard W. Birkinshaw, Brodie Bailey, Paola Favuzza, Melanie H. Dietrich, Wai-Hong Tham, Peter E. Czabotar, Kym Lowes, Zhuyan Guo, Nicholas Murgolo, Manuel de Lera Ruiz, John A. McCauley, Brad E. Sleebs, David Olsen, Alan F. Cowman
Publikováno v:
Structure (London, England : 1993). 30(7)
Plasmepsins IX (PMIX) and X (PMX) are essential aspartyl proteases for Plasmodium spp. egress, invasion, and development. WM4 and WM382 inhibit PMIX and PMX in Plasmodium falciparum and P. vivax. WM4 inhibits PMX, while WM382 is a dual inhibitor of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6183eb6a0c4dae275459130882bd01a0
https://pubmed.ncbi.nlm.nih.gov/35460613
https://pubmed.ncbi.nlm.nih.gov/35460613
Autor:
Janni Christensen, Wai-Hong Tham, David B. Olsen, Alan F. Cowman, Anthony N. Hodder, Brodie L Bailey, Peter E. Czabotar, Brad E. Sleebs, Zhuyan Guo, Tony Triglia, Stephen Scally, Nicholas Murgolo, John A. Mccauley, Anna Ngo, Richard W Birkinshaw, Paola Favuzza, Kym N Lowes, Melanie H. Dietrich, Manuel de Lera Ruiz
Plasmepsin IX (PMIX) and X (PMX) are aspartyl proteases of Plasmodium spp. that play essential roles in parasite egress, invasion and development. Consequently, they are important drug targets for Plasmodium falciparum and P. vivax. WM4 and WM382 are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4126c0504badacc5c905ca219c0808af
https://doi.org/10.21203/rs.3.rs-944781/v1
https://doi.org/10.21203/rs.3.rs-944781/v1
Autor:
Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72504 (2013)
A highly effective vaccine against Plasmodium falciparum malaria should induce potent, strain transcending immunity that broadly protects against the diverse population of parasites circulating globally. We aimed to identify vaccine candidates that f
Externí odkaz:
https://doaj.org/article/83942e4027cb4b7eb95d97939a7fb086
Publikováno v:
Protein Sci
PfSERA5, a significantly abundant protein present within the parasitophorous vacuole (PV) and essential for normal growth during the blood-stage life cycle of the malaria parasite Plasmodium falciparum, displays structural similarity to many other cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926a319761d0edd841dc9034f3e6a727
https://pubmed.ncbi.nlm.nih.gov/32955133
https://pubmed.ncbi.nlm.nih.gov/32955133
Autor:
Damien R Drew, Anthony N Hodder, Danny W Wilson, Michael Foley, Ivo Mueller, Peter M Siba, Arlene E Dent, Alan F Cowman, James G Beeson
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51023 (2012)
Apical Membrane Antigen 1 (AMA1) is a leading malaria vaccine candidate and a target of naturally-acquired human immunity. Plasmodium falciparum AMA1 is polymorphic and in vaccine trials it induces strain-specific protection. This antigenic diversity
Externí odkaz:
https://doaj.org/article/54726776553c433f9f07b1300513e92e
Autor:
Tana Taechalertpaisarn, Cecile Crosnier, S Josefin Bartholdson, Anthony N Hodder, Jenny Thompson, Leyla Y Bustamante, Danny W Wilson, Paul R Sanders, Gavin J Wright, Julian C Rayner, Alan F Cowman, Paul R Gilson, Brendan S Crabb
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41937 (2012)
The genomes of Plasmodium parasites that cause malaria in humans, other primates, birds, and rodents all encode multiple 6-cys proteins. Distinct 6-cys protein family members reside on the surface at each extracellular life cycle stage and those on t
Externí odkaz:
https://doaj.org/article/dca07fcb739f49178ad52a9708af4d0e
Autor:
Peter E. Czabotar, Kate E. Jarman, Alan F. Cowman, Brad E. Sleebs, Justin A Boddey, Jennifer K. Thompson, Richard Bestel de Lezongard, Helene Jousset Sabroux, William Nguyen, Anthony N. Hodder, Matthew T. O'Neill
Publikováno v:
European Journal of Medicinal Chemistry. 154:182-198
Plasmepsin V is an aspartyl protease that plays a critical role in the export of proteins bearing the Plasmodium export element (PEXEL) motif (RxLxQ/E/D) to the infected host erythrocyte, and thus the survival of the malaria parasite. Previously, dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a5a6426ec917d3db5732d8c22ae66e
https://doi.org/10.1016/j.ejmech.2018.05.022
https://doi.org/10.1016/j.ejmech.2018.05.022
Autor:
Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman
Publikováno v:
PLoS Pathogens, Vol 7, Iss 6, p e1002075 (2011)
Plasmodium falciparum, the causative agent of the most severe form of malaria in humans invades erythrocytes using multiple ligand-receptor interactions. The P. falciparum reticulocyte binding-like homologue proteins (PfRh or PfRBL) are important for
Externí odkaz:
https://doaj.org/article/2b1c565d161f40d6827975e6212fb2f5