Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anthony M. Slater"'
Autor:
Christine Marie Paul Lambert, Alan Girdwood, Andrew G. Leach, Catherine Bardelle, Andrew P. Garner, Helen Plant, J. S. Major, Brian Law, Dave Buttar, Kevin Blades, Louise Chapman, Nicola Colclough, Joanne V. Allen, Anthony M. Slater, Alexander G. Dossetter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5224-5229
A directed screen of a relatively small number of compounds, selected for kinase ATP pocket binding potential, yielded a novel series of hit compounds (1). Hit explosion on two binding residues identified compounds 27 and 43 as the best leads for an
Autor:
Adriano Henney, Claire A. Minshull, Derek Barratt, Siân Rowsell, David Waterson, Richard A. Pauptit, Holly Jepson, Paul Hawtin, Anthony M. Slater, William L. McPheat, S.M. Brockbank
Publikováno v:
Journal of Molecular Biology. 319:173-181
Matrix metalloproteinases (MMPs) and their inhibitors are important in connective tissue re-modelling in diseases of the cardiovascular system, such as atherosclerosis. Various members of the MMP family have been shown to be expressed in atherosclero
Autor:
Geoffrey A. Holdgate, Walter H.J. Ward, D. Huw Davies, Anthony M. Slater, Peter N. Cook, Leslie R'. Green
Publikováno v:
Biochemical Pharmacology. 48:659-666
Inhibition of tyrosine kinases is a possible approach for the treatment of cancer. We have investigated the catalytic mechanism of the epidermal growth factor receptor tyrosine kinase (EGF-RTK) in order to obtain information for use in structure-base
Publikováno v:
Journal of Medicinal Chemistry. 34:181-189
This paper describes the synthesis of a series of N-[2-(1-pyrrolidinyl)ethyl]acetamides (1), methylated at C1 and/or C2 of the ethyl linking group, and their biological evaluation as opioid kappa agonists. Conformational analysis of corresponding des
Autor:
David Waterson, J. S. Major, Robert Hugh Bradbury, David A. Roberts, A. A. Oldham, Anthony M. Slater, Janet E. Rivett, David Timms
Publikováno v:
Journal of Medicinal Chemistry. 33:2335-2342
A series of inhibitors of human renin have been synthesized, derived from combination of a 2-(8-propyl-6-pyridin-3-yl-1,2,4-triazolo[4,3-a]pyrazin-3-yl)- 3-pyridin- 3-ylpropionic acid moiety 6c with the hydroxyethylene isostere of the scissile amide