Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Anthony M. Heape"'
Autor:
Steffen Ohlmeier, Salla M. Kangas, Eeva-Mari Jouhilahti, Juha Peltonen, Raija Sormunen, Sirkku Peltonen, Anthony M. Heape
Publikováno v:
ResearcherID
Peripheral nerve myelination is a complex event resulting from spatially and temporally regulated reciprocal interactions between the neuron and myelin-forming Schwann cells. The dynamic process and the protein functional modules and networks that op
Autor:
Elina Jokinen, Ludwine Messiaen, Eeva-Mari Jouhilahti, Sirkku Peltonen, Juha Peltonen, Anthony M. Heape, Tom Callens
Publikováno v:
The American Journal of Pathology. 178:500-505
Cutaneous neurofibromas are the hallmarks of neurofibromatosis type 1 (NF1). They are composed of multiple cell types, and traditionally they are believed to arise from small nerve tributaries of the skin. A key finding in the context of this view ha
Autor:
Karolina Rasi, Mika Kallio, Raija Soininen, Taina Pihlajaniemi, Heikki Tanila, Saara Stavén, Anthony M. Heape, Merja Hurskainen, Pirkko Huhtala, Robin L. Avila, Raija Sormunen, Daniel A. Kirschner, Uolevi Tolonen, Anu Muona
Publikováno v:
The Journal of Neuroscience. 30:14490-14501
Although the Schwann cell basement membrane (BM) is required for normal Schwann cell terminal differentiation, the role of BM-associated collagens in peripheral nerve maturation is poorly understood. Collagen XV is a BM zone component strongly expres
Autor:
Salla M. Kangas, Anthony M. Heape, Peter Baumgärtel, Viivi Majava, Sung Ung Kang, Petri Kursula, Nobuhiro Hayashi, Matti Myllykoski, Gert Lubec, Chaozhan Wang
Publikováno v:
Amino Acids. 39:59-71
Myelin basic protein (MBP) is present between the cytoplasmic leaflets of the compact myelin membrane in both the peripheral and central nervous systems, and characterized to be intrinsically disordered in solution. One of the best-characterized prot
Autor:
Henrika Honkanen, Satu Päiväläinen, Marja Nissinen, Anthony M. Heape, Juha Peltonen, Salla M. Kangas, Maria H. Alanne, Riina M. Myllylä, Sirkku Peltonen, Outi Lahti
Publikováno v:
European Journal of Neuroscience. 26:953-964
Most studies of peripheral nerve myelination using culture models are performed with dorsal root ganglion neurons and Schwann cells pre-purified from the rat. The potential of this model is severely compromised by the lack of rat myelin mutants and t
Autor:
Ian Mohr, Henrik Paavilainen, K. Harila, R. K. Mattila, Anthony M. Heape, Salla M. Kangas, Veijo Hukkanen
Publikováno v:
The Journal of general virology. 96(8)
After a primary lytic infection at the epithelia, herpes simplex virus type 1 (HSV-1) enters the innervating sensory neurons and translocates to the nucleus, where it establishes a quiescent latent infection. Periodically, the virus can reactivate an
Publikováno v:
Protein & Peptide Letters. 12:709-712
Schistosoma japonicum glutathione S-transferase (SjGST) is a common fusion tag in recombinant protein production, and its 3-dimensional structure has been studied in the context of drug design. We have determined the crystal structure of non-fused Sj
Publikováno v:
Journal of Histochemistry & Cytochemistry. 52:1037-1046
In peripheral nerves, groups of Schwann cell–axon units are isolated from the adjacent tissues by the perineurium, which creates a diffusion barrier responsible for the maintenance of endoneurial homeostasis. The perineurium is formed by concentric
Publikováno v:
Journal of Neurochemistry. 84:533-545
The myelin-associated glycoprotein (MAG) is a transmembrane cell adhesion molecule participating in myelin formation and maintenance. Calcium-activated/-dependent proteolysis of myelin-associated glycoprotein by calpain and cathepsin L-like activitie
Publikováno v:
Molecular Brain Research. 87:22-30
The myelin-associated glycoprotein (MAG) exists as two isoforms, differing only by their respective cytoplasmic domains, that have been suggested to function in the formation and maintenance of myelin. In the present study, a 50 kDa protein binding d