Výsledky vyhledávání - "Anthony M. DeMaria"

A Conserved Core Region of the Scaffold NEMO is Essential for Signal-induced Conformational Change and Liquid-liquid Phase Separation

Autor: Christopher J. DiRusso, Anthony M. DeMaria, Judy Wong, Jack J. Jordanides, Adrian Whitty, Karen N. Allen, Thomas D. Gilmore

Publikováno v: bioRxiv

Scaffold proteins help mediate interactions between protein partners, often to optimize intracellular signaling. Herein, we use comparative, biochemical, biophysical, molecular, and cellular approaches to investigate how the scaffold protein NEMO con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852d9fc4b75571ece11a99ac158db0b6
https://europepmc.org/articles/PMC10245932/

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Navigating a Career in Innovation

Autor: Nabil Dib, Anthony M. DeMaria, Spencer B. King

Publikováno v: Journal of the American College of Cardiology. 79:e141-e142

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1abdba07ee389ba93ff382004334edfb
https://doi.org/10.1016/j.jacc.2021.08.077

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A Central Region of NF-κB Essential Modulator Is Required for IKKβ-Induced Conformational Change and for Signal Propagation

Autor: Anthony M. DeMaria, Thomas D. Gilmore, Suhaily Caban-Penix, Milad Babaei, Stefan Jehle, Robert Shaffer, Larisa Kagermazova, Yuekun Liu, Arisdelsy Cervantes, Adrian Whitty, Karen N. Allen, Lee Makowski

Publikováno v: Biochemistry. 58:2906-2920

NF-κB essential modulator (NEMO) regulates NF-κB signaling by acting as a scaffold for the kinase IKKβ to direct its activity toward the NF-κB inhibitor, IκBα. Here, we show that a highly conserved central region of NEMO termed the intervening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c540176c42cf56f6ac5aeaaa417faea6
https://doi.org/10.1021/acs.biochem.8b01316

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