Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anthony M. Boutelle"'
Autor:
Anthony M. Boutelle, Laura D. Attardi
Publikováno v:
Trends Cell Biol
Trends in cell biology, vol 31, iss 4
Trends in cell biology, vol 31, iss 4
The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53 suppresses tumorigenesis by transcriptionally regulating a network of target genes that play roles in various cellular processes. Though originally characterized as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42e42f681a18571e81c784fc795fc1e
https://doi.org/10.1016/j.tcb.2020.12.011
https://doi.org/10.1016/j.tcb.2020.12.011
Autor:
Nitin Raj, Mengxiong Wang, Jose A. Seoane, Richard L. Zhao, Alyssa M. Kaiser, Nancie A. Moonie, Janos Demeter, Anthony M. Boutelle, Craig H. Kerr, Abigail S. Mulligan, Clare Moffatt, Shelya X. Zeng, Hua Lu, Maria Barna, Christina Curtis, Howard Y. Chang, Peter K. Jackson, Laura D. Attardi
Publikováno v:
Mol Cell
The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to uncover new mechanisms through which p53 regulates gene expression using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fcf0667d8da72f08b88a03fd3626b9
https://europepmc.org/articles/PMC9807187/
https://europepmc.org/articles/PMC9807187/
Autor:
Clare Moffatt, Laura D. Attardi, Nancie A. Moonie, Peter K. Jackson, Mengxiong Wang, Howard Y. Chang, Jose A. Seoane, Anthony M. Boutelle, Christina Curtis, Nitin Raj, Abigail S. Mulligan, Alyssa M. Kaiser, Janos Demeter
SUMMARYThe p53 transcription factor, encoded by the most frequently mutated gene in human cancer, plays a critical role in tissue homeostasis in response to stress signals. The mechanisms through which p53 promotes downstream tumor suppressive gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5378cd475b13f5a42dc88048a4d9092b
https://doi.org/10.1101/2021.10.21.465324
https://doi.org/10.1101/2021.10.21.465324
Autor:
Yang Li, Liz J. Valente, Nitin Raj, Amy Tarangelo, Jiangbin Ye, Ralph J. DeBerardinis, Laura D. Attardi, Albert M. Li, Marwan Naciri, Kathryn T. Bieging-Rolett, Stephano S. Mello, Scott J. Dixon, Anthony M. Boutelle
Publikováno v:
The Journal of Cell Biology
Using oncogene-expressing cells to interrogate p53 function under physiological oxygen conditions, Valente et al. show that p53 deficiency drives concurrent dysregulation of a range of cellular processes. These findings highlight the pleiotropic effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6209ae71e9d1ca51ff37a30cd8a149
https://doi.org/10.1083/jcb.201908212
https://doi.org/10.1083/jcb.201908212
Autor:
Helen Philippou, Matthew J. Flick, James R. Byrnes, Clare Wilson, Alisa S. Wolberg, Anthony M. Boutelle, Chase B. Brandner
Publikováno v:
Blood. 128:1969-1978
Coagulation transglutaminase factor XIII (FXIII) exists in circulation as heterotetrameric proenzyme FXIII-A2B2 Effectively all FXIII-A2B2 circulates bound to fibrinogen, and excess FXIII-B2 circulates in plasma. The motifs that mediate interaction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5390ac7979ac5c8dbbc23d8272224526
https://doi.org/10.1182/blood-2016-04-712323
https://doi.org/10.1182/blood-2016-04-712323
Autor:
Christina Curtis, Sarah E. Pierce, Jose A. Seoane, Laura D. Attardi, Shauna L. Houlihan, Kathryn T. Bieging-Rolett, Andrew J. Connolly, Michael C. Bassik, Monte M. Winslow, Changyu Zhu, Anthony M. Boutelle, David W. Morgens, Ian P. Winters, Jacob McClendon, Alyssa M. Kaiser, Gene W. Yeo, Eric L. Van Nostrand, Brian A. Yee, Stephano S. Mello, Scott W. Lowe, Mengxiong Wang
Publikováno v:
Molecular cell, vol 80, iss 3
Mol Cell
Mol Cell
Although TP53 is the most commonly mutated gene in human cancers, the p53-dependent transcriptional programs mediating tumor suppression remain incompletely understood. Here, to uncover critical components downstream of p53 in tumor suppression, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe8c17a740e8364f2f5d66e0d521792
https://doi.org/10.1016/j.molcel.2020.10.022
https://doi.org/10.1016/j.molcel.2020.10.022