Výsledky vyhledávání - "Anthony M Treston"

Akademický článek

Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.

Autor: Michael Callahan, Anthony M Treston, Grace Lin, Marla Smith, Brian Kaufman, Mansoora Khaliq, Lisa Evans DeWald, Kevin Spurgers, Kelly L Warfield, Preeya Lowe, Matthew Duchars, Aruna Sampath, Urban Ramstedt

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010636 (2022)

BackgroundUV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in

Externí odkaz: https://doaj.org/article/1b9a38644e1447e182ac97752d59a1a1

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Identification of Endoplasmic Reticulum α-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design

Autor: Sharanbasappa S. Karade, Alexander Kolesnikov, Anthony M. Treston, Roy A. Mariuzza

Publikováno v: Biochemistry. 61(10)

All viruses depend on host cell proteins for replication. Denying viruses' access to the function of critical host proteins can result in antiviral activity against multiple virus families. In particular, small-molecule drug candidates which inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a29fde6ad165697be8d20dd2536486
https://pubmed.ncbi.nlm.nih.gov/35476408

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N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity

Autor: Sharanbasappa S. Karade, Michelle L. Hill, J. L. Kiappes, Rajkumar Manne, Balakishan Aakula, Nicole Zitzmann, Kelly L. Warfield, Anthony M. Treston, Roy A. Mariuzza

Publikováno v: Journal of medicinal chemistry. 64(24)

Most enveloped viruses rely on the host cell endoplasmic reticulum (ER) quality control (QC) machinery for proper folding of glycoproteins. The key ER α-glucosidases (α-Glu) I and II of the ERQC machinery are attractive targets for developing broad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddd94ffbb428625c3f25a726312d87f
https://pubmed.ncbi.nlm.nih.gov/34870992

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Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects

Autor: Michael Callahan, Anthony M. Treston, Grace Lin, Marla Smith, Brian Kaufman, Mansoora Khaliq, Lisa Evans DeWald, Kevin Spurgers, Kelly L. Warfield, Preeya Lowe, Matthew Duchars, Aruna Sampath, Urban Ramstedt

Publikováno v: PLoS neglected tropical diseases. 16(8)

Background UV-4 (N-(9’-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0873e9b2bf0101cdb41da839ce6559f0
https://pubmed.ncbi.nlm.nih.gov/35939501

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Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections

Autor: J. L. Kiappes, Alessandro T. Caputo, Raymond A. Dwek, Pietro Roversi, Nicholas Sheets, Kelly L. Warfield, Anthony M. Treston, Matthew Duchars, Nicole Zitzmann, Johan C. Hill, Dale L. Barnard, Dominic S. Alonzi, Sujan Shresta, Julia E. Biggins

Publikováno v: Journal of medicinal chemistry. 63(8)

Influenza and dengue viruses present a growing global threat to public health. Both viruses depend on the host endoplasmic reticulum (ER) glycoprotein folding pathway. In 2014, Sadat et al. reported two siblings with a rare genetic defect in ER α-gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ceb8cd281eba59e1fb9b3a0d9430c9b
https://pubmed.ncbi.nlm.nih.gov/32227946

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Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo

Autor: Thomas W. Geisbert, Travis K. Warren, Brennan Klose, Michael V. Callahan, Kelly S. Stuthman, Xiangguo Qiu, Kelly L. Warfield, Sean A. Van Tongeren, Joan B. Geisbert, Anthony M. Treston, Urban Ramstedt, Gary Wong, Chad E. Mire, Krystle N. Agans, Nicole L. Garza, Amy C. Shurtleff, Jay Wells

Publikováno v: Antiviral Research. 138:22-31

Iminosugars are host-directed antivirals with broad-spectrum activity. The iminosugar, N-butyl-deoxynojirimycin (NB-DNJ or Miglustat®), is used in humans for treatment of Gaucher's disease and has mild antiviral properties. More potent analogs of NB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ce10d1b702cba75a6f77f4cd606237
https://doi.org/10.1016/j.antiviral.2016.11.019

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GC-072: A Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens

Autor: Herbert P. Schweizer, Kelly L. Warfield, Sunisa Chirakul, Jeffry D Shearer, Michelle L Saylor, Henry S. Heine, George L. Drusano, Steven D. Zumbrun, Anthony M. Treston, Christine M Butler, Arnold Louie

Publikováno v: Antimicrobial Agents and Chemotherapy

Burkholderia pseudomallei, the etiological agent of melioidosis, is a Gram-negative bacterium with additional concern as a biothreat pathogen. The mortality rate from B. pseudomallei varies depending on the type of infection and extent of available h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c3d0f862b21ef671247285c662a272
https://pubmed.ncbi.nlm.nih.gov/31548183

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A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate

Autor: Jamie Arnott, Jens C. Eickhoff, Michael A. Carducci, Anthony M. Treston, Justine Yang Bruce, George Wilding, Roberto Pili, Glenn Liu, Theodore F. Logan

Publikováno v: Investigational New Drugs. 30:794-802

Background Current treatment for metastatic renal cell cancer with vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKI) have provided improved overall survival, but complete responses are rare. We conducted a multicenter phase I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ec510dad140ea56786328d236fd3f0
https://doi.org/10.1007/s10637-010-9618-9

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Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples

Autor: Anthony M. Treston, Gregory E. Agoston, LiQuan Wang, Gaetan Ladouceur, Zhenglai Fang, Mark Cushman

Publikováno v: Tetrahedron. 65:10535-10543

ENMD-1198 is a biologically active analogue of the antitumor drug 2-methoxyestradiol. Four human metabolites of ENMD-1198 were identified through synthesis and liquid chromatography/mass spectrometry comparisons of the metabolites with the synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16835af27c5d76cd878f24db9fc8b6eb
https://doi.org/10.1016/j.tet.2009.10.046

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