Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Anthony M Battram"'
1
Akademický článek
T cells isolated from G-CSF-treated multiple myeloma patients are suitable for the generation of BCMA-directed CAR-T cells
Autor: Anthony M. Battram, Aina Oliver-Caldés, Maria Suárez-Lledó, Miquel Lozano, Miquel Bosch i Crespo, Núria Martínez-Cibrián, Joan Cid, David F. Moreno, Luis Gerardo Rodríguez-Lobato, Alvaro Urbano-Ispizua, Carlos Fernández de Larrea
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 207-223 (2022)
Autologous cell immunotherapy using B cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cells is an effective novel treatment for multiple myeloma (MM). This therapy has only been used for relapsed and refractory patients, at
Externí odkaz: https://doaj.org/article/85ce7bb7085742eaa47debfe86d2dbc9
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3
Akademický článek
Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
Autor: Anthony M. Battram, Mireia Bachiller, Beatriz Martín-Antonio
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 12, p 4346 (2020)
Cellular senescence was first described as a physiological tumor cell suppressor mechanism that leads to cell growth arrest with production of the senescence-associated secretory phenotype known as SASP. The main role of SASP in physiological conditi
Externí odkaz: https://doaj.org/article/3746e4e0f289496eb0bfb57d68f0344c
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7
NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness
Autor: Alvaro Urbano-Ispizua, Mireia Bachiller, Anthony M Battram, Els Verhoeyen, Sebastian Ciro Carné, Manel Juan, Lorena Perez-Amill, Amer Najjar, Beatriz Martín-Antonio
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Journal for Immunotherapy of Cancer
BackgroundChimeric antigen receptor (CAR)-T cell immunotherapy has modified the concept of treatment in hematological malignancies. In comparison with pediatric patients, where responses are maintained over many years, older patients, such as those w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532cd0d39ad439cc032586b57f9952f8
https://jitc.bmj.com/content/9/8/e002866.full
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8
Il-15 enhances the persistence and function of bcma-targeting car-t cells compared to il-2 or il-15/il-7 by limiting car-t cell dysfunction and differentiation
Autor: Alvaro Urbano-Ispizua, Víctor López, Mireia Bachiller, Anthony M Battram, Beatriz Martín-Antonio, Carlos Fernández de Larrea
Publikováno v: Cancers, Vol 13, Iss 3534, p 3534 (2021)
Cancers
Volume 13
Issue 14
Simple Summary T cells modified with a chimeric antigen receptor (CAR) that targets BCMA, a protein expressed on malignant plasma cells, represent a novel treatment option for multiple myeloma. Despite initially eliminating the disease, the function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fc132080fb21e54cc5e28cc6f48d90
https://ddd.uab.cat/record/270661
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9
102 Cord-blood derived NK cells, and CAR-T cells, an attractive improved immunotherapy treatment to be considered for hematological malignancies
Autor: Mireia Bachiller García, Alvaro Urbano-Ispizua, Lorena Perez-Amill, Anthony M. Battram, Beatriz Martín-Antonio
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Multiple myeloma (MM) remains an incurable hematological malignancy where a proportion of patients relapse or become refractory to current treatments. Administration of autologous T cells modified with a chimeric antigen receptor (CAR) aga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63a8a76aeeae29bc57f4b9c2a98bdee
https://doaj.org/article/8a406dfda0404fcbb487f9eb3648f8e6
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10
104 BCMA-targeting CAR-T cells expanded in IL-15 have an improved phenotype for therapeutic use compared to those grown in IL-2 or IL-15/IL-7
Autor: Alvaro Urbano-Ispizua, Beatriz Martín-Antonio, Anthony M. Battram, Mireia Bachiller
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Chimeric antigen receptor-T (CAR-T) cells that target B cell maturation antigen (BCMA-CARs) have emerged as a promising treatment for multiple myeloma (MM). Despite impressive initial responses to BCMA-CAR therapy in clinical trials, relap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2654bc2a028ee75677e26ee704380e34
https://doi.org/10.1136/jitc-2020-sitc2020.0104
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