Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Anthony M, Mustoe"'
Autor:
Jayashree Kumar, Lela Lackey, Justin M Waldern, Abhishek Dey, Anthony M Mustoe, Kevin M Weeks, David H Mathews, Alain Laederach
Publikováno v:
eLife, Vol 11 (2022)
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Externí odkaz:
https://doaj.org/article/7e9b5b2f330645718e814d97ac9b25a0
Publikováno v:
Accounts of Chemical Research. 56:763-775
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::202eff11c305acfcbedc6a0cd954f85e
https://doi.org/10.1021/acs.accounts.2c00782
https://doi.org/10.1021/acs.accounts.2c00782
Autor:
Philip J Grayeski, Chase A Weidmann, Jayashree Kumar, Lela Lackey, Anthony M Mustoe, Steven Busan, Alain Laederach, Kevin M Weeks
Publikováno v:
Nucleic Acids Research. 50:9689-9704
SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive pulmonary disease (COPD) and liver cirrhosis, and specific variants in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb810ff2966ba613603ad6a2c8b20be
https://doi.org/10.1093/nar/gkac739
https://doi.org/10.1093/nar/gkac739
Chemical probing experiments have transformed RNA structure analysis, enabling high-throughput measurement of base-pairing in living cells. Dimethyl sulfate (DMS) is one of the most widely used structure probing reagents and has played a prominent ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a052fe00a0941e3eac2d62d825abc18
https://doi.org/10.1101/2023.04.10.536308
https://doi.org/10.1101/2023.04.10.536308
Autor:
Samuel W. Olson, Anne-Marie W. Turner, J. Winston Arney, Irfana Saleem, Chase A. Weidmann, David M. Margolis, Kevin M. Weeks, Anthony M. Mustoe
Publikováno v:
Mol Cell
7SK is a conserved non-coding RNA that regulates transcription by sequestering the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but characterizing RNA dynamics in cells remains an unsolved challenge. We develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349b6fbdb4ca3ed7b5ffa7167719cb6f
https://europepmc.org/articles/PMC9081252/
https://europepmc.org/articles/PMC9081252/
Autor:
David M. Margolis, Anthony M. Mustoe, Chase A. Weidmann, I. Saleem, S. W. Olson, Kevin M. Weeks, J. W. Arney, Anne-Marie W. Turner
Summary7SK is a highly conserved non-coding RNA that regulates eukaryotic transcription by sequestering positive transcription elongation factor b (P-TEFb). 7SK regulatory function likely entails changes in RNA structure, but characterizing dynamic R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82131bedc96ccfedbf2ec2b7047d8593
https://doi.org/10.1101/2021.09.16.460563
https://doi.org/10.1101/2021.09.16.460563
Autor:
Jayashree, Kumar, Lela, Lackey, Justin M, Waldern, Abhishek, Dey, Anthony M, Mustoe, Kevin M, Weeks, David H, Mathews, Alain, Laederach
Publikováno v:
eLife. 11
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fc7c50a9184214a8a0540edd39de861
https://pubmed.ncbi.nlm.nih.gov/35695373
https://pubmed.ncbi.nlm.nih.gov/35695373
Publikováno v:
Proc Natl Acad Sci U S A
RNA structure and dynamics are critical to biological function. However, strategies for determining RNA structure in vivo are limited, with established chemical probing and newer duplex detection methods each having deficiencies. Here we convert the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819fb351245e589de28829593ddf5ef7
https://doi.org/10.1073/pnas.1905491116
https://doi.org/10.1073/pnas.1905491116
Publikováno v:
Am J Hum Genet
Synonymous codon usage has been identified as an important determinant of translational efficiency and mRNA stability in model organisms and human cell lines. However, to date, population genetics studies have failed to observe evolutionary constrain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362caa5d4e44a4f77a29a81555798521
https://pubmed.ncbi.nlm.nih.gov/35931054
https://pubmed.ncbi.nlm.nih.gov/35931054