Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anthony Lai Ling"'
Autor:
Lars Ynddal, Ulla G. Sidelmann, Christian K. Sams, Peter Madsen, Carsten Behrens, Lotte Bjerre Knudsen, Behrend F. Lundt, Jesper Lau, Shengua Shi, Christian L. Brand, Anthony Lai Ling, Lone Pridal, Plewe Michael Bruno, Dan Kiel
Publikováno v:
Journal of Medicinal Chemistry. 50:113-128
A weak human glucagon receptor antagonist with an IC50 of 7 microM was initially found by screening of libraries originally targeted to mimic the binding of the glucagon-like peptide (GLP-1) hormone to its receptor. Optimization of this hit for bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176d2edc234cfc1c2fe14f45862ddf39
https://doi.org/10.1021/jm058026u
https://doi.org/10.1021/jm058026u
Autor:
Jesper Lau, James Lakis, Shenghua Shi, Javier Gonzalez, Teston Kimberly Ann, Lotte Bjerre Knudsen, Yufeng Hong, John M. May, Douglas E. Murphy, Atsuo Kuki, Dan Kiel, Anthony Lai Ling, Kenna Anderes, Alex Polinsky, Vlad E. Gregor, John B. Porter
Publikováno v:
Journal of Medicinal Chemistry. 44:3141-3149
High throughput screening of our small molecule combinatorial library identified a class of benzoylnaphthalenehydrazones with modest affinity for the human glucagon receptor. Optimization of this initial hit through a series of targeted libraries and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e26b8f7a7796258392d71a65a8ad93
https://doi.org/10.1021/jm000547o
https://doi.org/10.1021/jm000547o
Autor:
Johnson Michael David, Plewe Michael Bruno, Dan Kiel, Kimberly Ann Teston, Ulla G. Sidelmann, Douglas E. Murphy, Min Teng, Atsuo Kuki, Shenghua Shi, Christian K. Sams, James Lakis, Kenna Anderes, Larry Kenneth Truesdale, Jun Feng, Birgitte Andersen, Lars Ynddal, Peter Madsen, John M. May, Jesper Lau, Lotte Bjerre Knudsen, Anthony Lai Ling, Vlad E. Gregor, Christian L. Brand
Publikováno v:
Journal of medicinal chemistry. 45(26)
Highly potent human glucagon receptor (hGluR) antagonists have been prepared employing both medicinal chemistry and targeted libraries based on modification of the core (proximal) dimethoxyphenyl group, the benzyl ether linkage, as well as the (dista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f8de2ec1aa4425ee9bc81ce1098b95
https://pubmed.ncbi.nlm.nih.gov/12477359
https://pubmed.ncbi.nlm.nih.gov/12477359
Autor:
Christian K. Sams, Lotte Bjerre Knudsen, Teston Kimberly Ann, Eugenia A. Iatsimirskaia, Anthony Lai Ling, Atsuo Kuki, Peter Madsen, Dan Kiel, Doug Murphy, Vlad E. Gregor, Jesper Lau, Javier Gonzalez, Christian L. Brand, Plewe Michael Bruno, John M. May, James Lakis, Shenghua Shi, Larry Kenneth Truesdale, Ulla G. Sidelmann, Alex Polinsky, Kenna Anderes
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
A series of alkylidene hydrazide derivatives containing an alkoxyaryl moiety was optimized. The resulting hydrazide-ethers were competitive antagonists at the human glucagon receptor. Pharmacokinetic experiments showed fast clearance of most of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1394aba7e4083e65bb5700d91b4cd2dc
https://pubmed.ncbi.nlm.nih.gov/11844695
https://pubmed.ncbi.nlm.nih.gov/11844695
Autor:
Jing Chen, Mary Theresa Didiuk, Nicole Barucci, Beijing Tan, Timothy P. Rolph, Peter J. Oates, Anne M. Brodeur, Leena Patel, Spiros Liras, Patricia Bourassa, Paul DaSilva-Jardine, Kevin J. Filipski, Laurel Sweet, Christopher S. Jones, John D. Knafels, Jeffrey A. Pfefferkorn, Nahor Haddish-Berhane, Karen Atkinson, Karki Kapil Kumar, Gary Erik Aspnes, David R. Derksen, Wei Song, David E. Perregaux, Joshua R. Dunetz, William M. Hungerford, Jeffrey W. Corbett, James Saenz, James A. Landro, Cong Huang, Francis Bourbounais, Margit MacDougall, Chulho Choi, Martin A. Berliner, Arindrajit Basak, Hud Lawrence Risley, Jian-Cheng Li, Xiayang Qiu, Jianwei Bian, Alan Robertson, Judith L. Treadway, John Litchfield, Angel Guzman-Perez, Shenping Liu, John William Benbow, John C. Pettersen, Theresa D’Aquila, Meihua Tu, Christian Perreault, Anthony Lai Ling, Rena Burbey, David A. Beebe, Kevin Daniel Freeman-Cook, Robert J. Aiello, Mark Ammirati, Xi Song, Amanda L. Lapworth
Publikováno v:
MedChemComm. 2:828
Glucokinase is a key regulator of glucose homeostasis and small molecule activators of this enzyme represent a promising opportunity for the treatment of Type 2 diabetes. Several glucokinase activators have advanced to clinical studies and demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd44038e0dcaf826f1fe7dbf044dc84
https://doi.org/10.1039/c1md00116g
https://doi.org/10.1039/c1md00116g