Biophysical Characterization of α-Synuclein and Rotenone Interaction

Autor: Anthony L. Fink, Ólöf Einarsdóttir, Blanca A. Silva, Vladimir N. Uversky

Publikováno v: Biomolecules, Vol 3, Iss 3, Pp 703-732 (2013)

Previous studies revealed that pesticides interact with α-synuclein and accelerate the rate of fibrillation. These results are consistent with the prevailing hypothesis that the direct interaction of α-synuclein with pesticides is one of many suspe

Externí odkaz: https://doaj.org/article/5d51f2c75fdd465a9d83c78b551f9348

Oxidized quercetin inhibits α-synuclein fibrillization

Autor: Anthony L. Fink, Shubo Han, Min Zhu

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1830:2872-2881

Background α-Synucein is a small (14 kDa), abundant, intrinsically disordered presynaptic protein, whose aggregation is believed to be a critical step in Parkinson's disease (PD). Oxidative stress is reported to be a risk factor for dopamine cell de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9428974d25eedc064c7fe11823a2d3bf
https://doi.org/10.1016/j.bbagen.2012.12.027

Peculiarities of Copper Binding to α-Synuclein

Autor: Colin S. Burns, Anthony L. Fink, Vladimir N. Uversky, Atta Ahmad

Publikováno v: Journal of Biomolecular Structure and Dynamics. 29:825-842

Heavy metals have been implicated as the causative agents for the pathogenesis of the most prevalent neurodegenerative disease. Various mechanisms have been proposed to explain the toxic effects of metals ranging from metal-induced oxidation of prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f7de291bc9e378be29731404b8f575
https://doi.org/10.1080/073911012010525023

Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

Autor: Wenbo Zhou, Vladimir N. Uversky, Donato A. Di Monte, Anthony L. Fink, Chunmei Long, Stephen H. Reaney

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2010, 1802 (3), pp.322. ⟨10.1016/j.bbadis.2009.12.004⟩

Oxidative stress and aggregation of the presynaptic protein alpha-synuclein (alpha-Syn) are implied in the pathogenesis of Parkinson's disease and several other neurodegenerative diseases. Various posttranslational modifications, such as oxidation, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a14bab764927702d7adf7251bc3d844

Calbindin-D28K acts as a calcium-dependent chaperone suppressing α-synuclein fibrillation in vitro

Autor: Anthony L. Fink, Vladimir N. Uversky, Wenbo Zhou, Chunmei Long

Publikováno v: Open Life Sciences, Vol 5, Iss 1, Pp 11-20 (2010)

α-Synuclein, a natively unfolded protein aggregation which is implicated in the pathogenesis of Parkinson’s disease and several other neurodegenerative diseases, is known to interact with a great number of unrelated proteins. Some of these protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f793a4707ecd07e191c91ffadf9fcf1
https://doi.org/10.2478/s11535-009-0071-8