Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Anthony L. Desbien"'
Autor:
Kelsey E. Sivick, Anthony L. Desbien, Laura Hix Glickman, Gabrielle L. Reiner, Leticia Corrales, Natalie H. Surh, Thomas E. Hudson, Uyen T. Vu, Brian J. Francica, Tamara Banda, George E. Katibah, David B. Kanne, Justin J. Leong, Ken Metchette, Jacob R. Bruml, Chudi O. Ndubaku, Jeffrey M. McKenna, Yan Feng, Lianxing Zheng, Steven L. Bender, Charles Y. Cho, Meredith L. Leong, Andrea van Elsas, Thomas W. Dubensky, Jr., Sarah M. McWhirter
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3074-3085.e5 (2018)
Summary: Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is us
Externí odkaz:
https://doaj.org/article/6640eed869a2425eb7c9442fb0d88d76
Autor:
Anthony L. Desbien, Neal Van Hoeven, Steven J. Reed, Allen C. Casey, John D. Laurance, Susan L. Baldwin, Malcolm S. Duthie, Steven G. Reed, Darrick Carter
Publikováno v:
BioTechniques, Vol 54, Iss 6, Pp 345-348 (2013)
We have developed an influenza hemagglutinin protein microarray to assess humoral recognition of diverse influenza strains induced by vaccination and infection. Each array consists of controls and 127 hemagglutinin antigens from 60 viruses, spotted i
Externí odkaz:
https://doaj.org/article/d5c38ac9fe1f4e9791c7d7e70ea2457c
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a915ee7bfe3efd5944b3b40db828628
https://doi.org/10.1158/2326-6066.22540031.v1
https://doi.org/10.1158/2326-6066.22540031.v1
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
S1: Timeline of necrosis after CDN injection. S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes. S3: B16F10 is not directly killed by CDN exposure and behaves similarly to other mouse and human cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ac9846b27c83bca6e21a030b23fe47
https://doi.org/10.1158/2326-6066.22540019.v1
https://doi.org/10.1158/2326-6066.22540019.v1
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
The cGAS–STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (i.t.) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509df28f14c303f465adcdc06aad30ad
https://doi.org/10.1158/2326-6066.c.6549257
https://doi.org/10.1158/2326-6066.c.6549257
Autor:
Victor Lira, Meredith L. Leong, Edward E. Lemmens, Anthony L. Desbien, Thomas E. Hudson, Ruben Flores, William G. Hanson, Daniel A. Portnoy, Thomas W. Dubensky, George E. Katibah, Peter Lauer, Gonzalo Barajas, Weiwen Deng
Publikováno v:
Proceedings of the National Academy of Sciences. 115:8179-8184
Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy. We are evaluating live-attenuated, double-deleted Listeria mon
Autor:
Meredith L. Leong, Laura Hix Glickman, Ali Ghasemzadeh, Kelsey E. Sivick, Drew M. Pardoll, Andrew B. Sharabi, Thomas W. Dubensky, Debebe Theodros, Brian Francica, Sarah M. McWhirter, Gabrielle L. Reiner, Ariel E. Marciscano, Charles G. Drake, Anthony L. Desbien
Publikováno v:
Cancer Immunology Research
The cGAS–STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (i.t.) in
Autor:
Anthony L. Desbien, Darrick Carter, Christopher B. Fox, Hilton R. Bailor, Steven G. Reed, Hong Liang, Mark T. Orr, Malcolm S. Duthie, Steven J. Reed, Natasha Dubois Cauwelaert
Publikováno v:
The Journal of Immunology. 197:4351-4359
Designing modern vaccine adjuvants depends on understanding the cellular and molecular events that connect innate and adaptive immune responses. The synthetic TLR4 agonist glycopyranosyl lipid adjuvant (GLA) formulated in a squalene-in-water emulsion
Autor:
Susan L. Baldwin, Anthony L. Desbien, Emily Gage, Mark T. Orr, Natasha Dubois Cauwelaert, Rhea N. Coler, Kimberly A. Hofmeyer
Publikováno v:
European Journal of Immunology. 46:2719-2729
The contribution of B cells to immunity against many infectious diseases is unquestionably important and well characterized. Here, we sought to determine the role of B cells in the induction of T helper 1 (TH1) CD4+ T cells upon vaccination with a tu
Autor:
George E. Katibah, Sarah M. McWhirter, Kelsey E. Sivick, Natalie H. Surh, Eric P. Grewal, Thomas W. Dubensky, Anthony L. Desbien
Publikováno v:
The Journal of Immunology. 198:4183-4185
STING is a signaling protein encoded by the human TMEM173 gene that is central to the host response to infection. Upon binding cyclic dinucleotides (CDNs), STING activates transcriptional programs that orchestrate innate and adaptive immune responses