Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Anthony L. Desbien"'
Autor:
Kelsey E. Sivick, Anthony L. Desbien, Laura Hix Glickman, Gabrielle L. Reiner, Leticia Corrales, Natalie H. Surh, Thomas E. Hudson, Uyen T. Vu, Brian J. Francica, Tamara Banda, George E. Katibah, David B. Kanne, Justin J. Leong, Ken Metchette, Jacob R. Bruml, Chudi O. Ndubaku, Jeffrey M. McKenna, Yan Feng, Lianxing Zheng, Steven L. Bender, Charles Y. Cho, Meredith L. Leong, Andrea van Elsas, Thomas W. Dubensky, Jr., Sarah M. McWhirter
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3074-3085.e5 (2018)
Summary: Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is us
Externí odkaz:
https://doaj.org/article/6640eed869a2425eb7c9442fb0d88d76
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a915ee7bfe3efd5944b3b40db828628
https://doi.org/10.1158/2326-6066.22540031.v1
https://doi.org/10.1158/2326-6066.22540031.v1
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
S1: Timeline of necrosis after CDN injection. S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes. S3: B16F10 is not directly killed by CDN exposure and behaves similarly to other mouse and human cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ac9846b27c83bca6e21a030b23fe47
https://doi.org/10.1158/2326-6066.22540019.v1
https://doi.org/10.1158/2326-6066.22540019.v1
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
The cGAS–STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (i.t.) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509df28f14c303f465adcdc06aad30ad
https://doi.org/10.1158/2326-6066.c.6549257
https://doi.org/10.1158/2326-6066.c.6549257
Autor:
Anthony L. Desbien, Neal Van Hoeven, Steven J. Reed, Allen C. Casey, John D. Laurance, Susan L. Baldwin, Malcolm S. Duthie, Steven G. Reed, Darrick Carter
Publikováno v:
BioTechniques, Vol 54, Iss 6, Pp 345-348 (2013)
We have developed an influenza hemagglutinin protein microarray to assess humoral recognition of diverse influenza strains induced by vaccination and infection. Each array consists of controls and 127 hemagglutinin antigens from 60 viruses, spotted i
Externí odkaz:
https://doaj.org/article/d5c38ac9fe1f4e9791c7d7e70ea2457c
Autor:
Natasha Dubois Cauwelaert, Anthony L Desbien, Thomas E Hudson, Samuel O Pine, Steven G Reed, Rhea N Coler, Mark T Orr
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146372 (2016)
The Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant formulated in a stable emulsion (GLA-SE) promotes strong TH1 and balanced IgG1/IgG2 responses to protein vaccine antigens. This enhanced immunity is sufficient to provide protection again
Externí odkaz:
https://doaj.org/article/9f915c23edb44b2d9941d80c3a0e1d95
Autor:
Victor Lira, Meredith L. Leong, Edward E. Lemmens, Anthony L. Desbien, Thomas E. Hudson, Ruben Flores, William G. Hanson, Daniel A. Portnoy, Thomas W. Dubensky, George E. Katibah, Peter Lauer, Gonzalo Barajas, Weiwen Deng
Publikováno v:
Proceedings of the National Academy of Sciences. 115:8179-8184
Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy. We are evaluating live-attenuated, double-deleted Listeria mon
Autor:
Meredith L. Leong, Laura Hix Glickman, Ali Ghasemzadeh, Kelsey E. Sivick, Drew M. Pardoll, Andrew B. Sharabi, Thomas W. Dubensky, Debebe Theodros, Brian Francica, Sarah M. McWhirter, Gabrielle L. Reiner, Ariel E. Marciscano, Charles G. Drake, Anthony L. Desbien
Publikováno v:
Cancer Immunology Research
The cGAS–STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (i.t.) in
Autor:
Meredith L. Leong, Weiwen Deng, Chudi Ndubaku, Sarah M. McWhirter, Lianxing Zheng, Ken Metchette, Kelsey Sivick Gauthier, Jeffery M. McKenna, Laura Hix Glickman, Charles Y. Cho, Tamara Schroeder, Anthony L. Desbien, Natalie H. Surh, Andrea van Elsas, Bender Steven Lee, Yan Feng, Leticia Corrales, Justin Leong, Brian Francica, Gabrielle L. Reiner
Publikováno v:
Cancer Immunology Research. 8:PR09-PR09
Stimulator of interferon genes (STING) is a critical component of an innate immune pathway that activates robust antiviral and antitumor responses in mouse models. Activation of the STING pathway by intratumoral (IT) injection of synthetic cyclic din
Autor:
Anthony L. Desbien, Darrick Carter, Christopher B. Fox, Hilton R. Bailor, Steven G. Reed, Hong Liang, Mark T. Orr, Malcolm S. Duthie, Steven J. Reed, Natasha Dubois Cauwelaert
Publikováno v:
The Journal of Immunology. 197:4351-4359
Designing modern vaccine adjuvants depends on understanding the cellular and molecular events that connect innate and adaptive immune responses. The synthetic TLR4 agonist glycopyranosyl lipid adjuvant (GLA) formulated in a squalene-in-water emulsion