Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Anthony L Gotter"'
Autor:
Pamela L. Tannenbaum, Joanne eStevens, Jacquelyn eBinns, Alan eSavitz, Susan L Garson, Steven V Fox, Paul eColeman, Scott D Kuduk, Anthony L Gotter, Michael eMarino, Spencer J Tye, Jason eUslaner, Christopher J Winrow, John J Renger
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 8 (2014)
The ability to awaken from sleep in response to important stimuli is a critical feature of normal sleep, as is maintaining sleep continuity in the presence of irrelevant background noise. Dual orexin receptor antagonists (DORAs) effectively promote s
Externí odkaz:
https://doaj.org/article/bc2e2cdd06ec407c9158c769a6c72cea
Autor:
Jayaraju Dheekollu, Andreas Wiedmer, James Hayden, David Speicher, Anthony L Gotter, Tim Yen, Paul M Lieberman
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19596 (2011)
The mechanisms that coordinate the termination of DNA replication with progression through mitosis are not completely understood. The human Timeless protein (Tim) associates with S phase replication checkpoint proteins Claspin and Tipin, and plays an
Externí odkaz:
https://doaj.org/article/2fa2895d1f70430e8bfec8249c961ac0
Autor:
Jim J. Hagan, John J. Renger, Thomas S. Kilduff, Paul J. Coleman, Jerome M. Siegel, Jyrki P. Kukkonen, Christopher J. Winrow, Luis de Lecea, Daniel Hoyer, Roderick A. Porter, Anthony L. Gotter, Gregor J Sutcliffe, Neil Upton
Publikováno v:
IUPHAR BPS Guide Pharm CITE
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [42]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1196f26965e8dd135a136421a8771cb
https://doi.org/10.2218/gtopdb/f51/2021.3
https://doi.org/10.2218/gtopdb/f51/2021.3
Autor:
Sarah L Huszar Agrapides, Susan E. Browne, Jeffrey W. Schubert, Jaime Lynn Bunda, Robert Gomez, Tynebor Robert M, John M. Sanders, Melissa Egbertson, Kristen L.G. Jones, Jason M. Uslaner, Natasa Pajkovic, James Mulhearn, Anthony L. Gotter, Christopher D. Cox, Brian C. Magliaro, Barbara Hanney, Jenny Wai, Julie A. O'Brien, Scott T. Harrison, Stefania Risso, Anne Marie Taylor, John A. Mccauley, Sean M. Smith
Publikováno v:
ChemMedChem. 14:943-951
Herein we describe the discovery and optimization of a new series of 2,3-disubstituted and 2,3,6-trisubstituted muscarinic acetylcholine receptor 4 (M4 ) positive allosteric modulators (PAMs). Iterative libraries enabled rapid exploration of one-dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77782222be3d0457fcb67bd3fe6f175d
https://doi.org/10.1002/cmdc.201900088
https://doi.org/10.1002/cmdc.201900088
Autor:
Laura A. Grafe, Anthony L. Gotter, Sandra Luz, Darrell Eacret, Chris J. Winrow, John J. Renger, Seema Bhatnagar
Publikováno v:
Neuroscience. 348:313-323
Orexins are hypothalamic neuropeptides that have a documented role in mediating the acute stress response. However, their role in habituation to repeated stress, and the role of orexin receptors (OX1R and OX2R) in the stress response, has yet to be d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22314aabe4cd18431fa760166ee93084
https://doi.org/10.1016/j.neuroscience.2017.02.038
https://doi.org/10.1016/j.neuroscience.2017.02.038
Publikováno v:
Annual Review of Pharmacology and Toxicology. 57:509-533
Historically, pharmacological therapies have used mechanisms such as γ-aminobutyric acid A (GABAA) receptor potentiation to drive sleep through broad suppression of central nervous system activity. With the discovery of orexin signaling loss as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f03b823bb14ac4fe502377dc24ac029
https://doi.org/10.1146/annurev-pharmtox-010716-104837
https://doi.org/10.1146/annurev-pharmtox-010716-104837
Autor:
Anthony L. Gotter, Lindsay Clark, Charles M. Harrell, Thomas H. Scheuermann, Christopher J. Winrow, Paul J. Coleman, Chad A. Brautigam, Anthony J. Roecker, Zhenhua Shao, Kerim Babaoglu, Jie Yin, John J. Renger, Daniel M. Rosenbaum
Publikováno v:
Nature Structural & Molecular Biology. 23:293-299
The orexin (also known as hypocretin) G protein-coupled receptors (GPCRs) regulate sleep and other behavioral functions in mammals, and are therapeutic targets for sleep and wake disorders. The human receptors hOX1R and hOX2R, which are 64% identical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64edb47861f2716a32cbead50bcb0db
https://doi.org/10.1038/nsmb.3183
https://doi.org/10.1038/nsmb.3183
Autor:
Terrence P. McDonald, Christopher J. Winrow, Anthony L. Gotter, Hongyu A Liang, Paul J. Coleman, Karen M. Smith, John J. Renger, Scott D. Kuduk, Raul Sanoja
Publikováno v:
Journal of Neurogenetics. 30:32-41
Orexin signaling, known to modulate arousal and vigilance, is also involved in nociception as orexin neurons project to regions of the brain and spinal cord involved in pain processing, and the administration of orexin peptides can alter pain respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3fd3043d42adb2cd34e407d179c560
https://doi.org/10.3109/01677063.2016.1171862
https://doi.org/10.3109/01677063.2016.1171862
Autor:
Jane Dobkin, Anthony L. Gotter, Christopher J. Winrow, Laura A. Grafe, Darrell Eacret, Seema Bhatnagar, John J. Renger
Publikováno v:
Behavioural brain research. 356
Orexins are neuropeptides synthesized in the lateral hypothalamus that influence arousal, feeding, reward pathways, and the response to stress. However, the role of orexins in repeated stress is not fully characterized. Here, we examined how orexins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb5f6d10f2c8358e724a39ca02b9733
https://pubmed.ncbi.nlm.nih.gov/29902478
https://pubmed.ncbi.nlm.nih.gov/29902478
Autor:
Christopher J. Winrow, Vance D. Gao, Martha Hotz Vitaterna, Fred W. Turek, Anthony L. Gotter, Karrie Fitzpatrick, Joshua Millstein, Andrew Kasarskis, Peng Jiang, Joseph R. Scarpa, Christopher Olker, John J. Renger
Publikováno v:
Science Advances
We identified gene networks linking sleep and affect, highlighting those oppositely perturbed by sleep loss and depression.
To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/
To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d9c7da2ffaaaf0d3fe876aca272b34
https://pubmed.ncbi.nlm.nih.gov/30050989
https://pubmed.ncbi.nlm.nih.gov/30050989