Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson’s disease

Autor: Anthony L. Gaeta, Karolina Willicott, Corey W. Willicott, Luke E. McKay, Candice M. Keogh, Tyler J. Altman, Logan C. Kimble, Abigail L. Yarbrough, Kim A. Caldwell, Guy A. Caldwell

Publikováno v: iScience, Vol 26, Iss 6, Pp 106859- (2023)

Summary: Failure of inherently protective cellular processes and misfolded protein-associated stress contribute to the progressive loss of dopamine (DA) neurons characteristic of Parkinson’s disease (PD). A disease-modifying role for the microbiome

Externí odkaz: https://doaj.org/article/110ccf8d94304ef59fa69e95a0718c71

Systemic RNA interference-defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

Autor: Anthony L. Gaeta, J. Brucker Nourse, Karolina Willicott, Luke E. McKay, Candice M. Keogh, Kylie Peter, Shannon N. Russell, Shusei Hamamichi, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell

The fine-tuning of gene expression is critical for all cellular processes; aberrations in this activity can lead to pathology, and conversely, resilience. As their role in coordinating organismal responses to both internal and external factors have i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::897842d29e4be7f222c24eae3b600a3b
https://doi.org/10.1101/2022.02.23.481573

A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6

Autor: Gabriela Caraveo, Kim A. Caldwell, Jessica Lacoste, Yongbo Zhang, Damian B. van Rossum, Marco Tonelli, Sergei Kuchin, Aishwarya Shevade, Sofia Zaichick, Anthony L. Gaeta, Guy A. Caldwell, Daayun Chung, Mikko Taipale, Jeffrey N. Savas, Shivani Agarwal, Dirk Fasshauer, G. Wiersum, Kaitlyn McGrath, Ludmilla Shuvalova, Wenyu Wen, Mykola Dergai, Andrew K. Shum

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 12, pp. e2016730118

Significance Ykt6 is a conserved SNARE that plays critical roles along multiple vesicular pathways. To achieve its function, Ykt6 cycles between the cytosol and membrane-bound compartments through reversible lipidation. The mechanism that regulates t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bd0e23041df6f7c5e6861afa9cb4ac
http://europepmc.org/articles/PMC8000380

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s Disease

Autor: Guy A. Caldwell, Kim A. Caldwell, Anthony L. Gaeta

Publikováno v: Brain Sciences, Vol 9, Iss 4, p 73 (2019)
Brain Sciences

Parkinson’s Disease (PD) is the second-most common neurodegenerative disease in the world, yet the fundamental and underlying causes of the disease are largely unknown, and treatments remain sparse and impotent. Several biological systems have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea7a9f767560709ae3b29da882ca748
https://www.mdpi.com/2076-3425/9/4/73