Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Anthony L, Fink"'
Publikováno v:
Biomolecules, Vol 3, Iss 3, Pp 703-732 (2013)
Previous studies revealed that pesticides interact with α-synuclein and accelerate the rate of fibrillation. These results are consistent with the prevailing hypothesis that the direct interaction of α-synuclein with pesticides is one of many suspe
Externí odkaz:
https://doaj.org/article/5d51f2c75fdd465a9d83c78b551f9348
Publikováno v:
Parkinson's Disease, Vol 2010 (2010)
α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. Currently, there is no approved therape
Externí odkaz:
https://doaj.org/article/d6a4ffc2de6d4a78a3343abcc5fee0c7
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1830:2872-2881
Background α-Synucein is a small (14 kDa), abundant, intrinsically disordered presynaptic protein, whose aggregation is believed to be a critical step in Parkinson's disease (PD). Oxidative stress is reported to be a risk factor for dopamine cell de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9428974d25eedc064c7fe11823a2d3bf
https://doi.org/10.1016/j.bbagen.2012.12.027
https://doi.org/10.1016/j.bbagen.2012.12.027
Publikováno v:
Molecular Neurobiology. 47:598-612
Epidemiological, population-based case-control, and experimental studies at the molecular, cellular, and organism levels revealed that exposure to various environmental agents, including a number of structurally different agrochemicals, may contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd271881b624000abbc6e58a91cb7aa
https://doi.org/10.1007/s12035-012-8333-2
https://doi.org/10.1007/s12035-012-8333-2
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 29:825-842
Heavy metals have been implicated as the causative agents for the pathogenesis of the most prevalent neurodegenerative disease. Various mechanisms have been proposed to explain the toxic effects of metals ranging from metal-induced oxidation of prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f7de291bc9e378be29731404b8f575
https://doi.org/10.1080/073911012010525023
https://doi.org/10.1080/073911012010525023
Publikováno v:
Protein & Peptide Letters. 18:230-240
Under certain in vitro conditions, α-synuclein, an abundant 14kDa presynaptic intrinsically disordered protein involved in the pathogenesis of Parkinsons disease (PD), forms amyloid fibrils which resemble those found in Lewy bodies of PD patients. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74cdfb155541cb8d34f90a27364c9c0b
https://doi.org/10.2174/092986611794578332
https://doi.org/10.2174/092986611794578332
Autor:
Wenbo Zhou, Vladimir N. Uversky, Donato A. Di Monte, Anthony L. Fink, Chunmei Long, Stephen H. Reaney
Publikováno v:
Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2010, 1802 (3), pp.322. ⟨10.1016/j.bbadis.2009.12.004⟩
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2010, 1802 (3), pp.322. ⟨10.1016/j.bbadis.2009.12.004⟩
Oxidative stress and aggregation of the presynaptic protein alpha-synuclein (alpha-Syn) are implied in the pathogenesis of Parkinson's disease and several other neurodegenerative diseases. Various posttranslational modifications, such as oxidation, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a14bab764927702d7adf7251bc3d844
Publikováno v:
Open Life Sciences, Vol 5, Iss 1, Pp 11-20 (2010)
α-Synuclein, a natively unfolded protein aggregation which is implicated in the pathogenesis of Parkinson’s disease and several other neurodegenerative diseases, is known to interact with a great number of unrelated proteins. Some of these protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f793a4707ecd07e191c91ffadf9fcf1
https://doi.org/10.2478/s11535-009-0071-8
https://doi.org/10.2478/s11535-009-0071-8
Publikováno v:
The Open Proteomics Journal. 3:1-7
α-Synuclein (α-Syn) is a small intrinsically disordered presynaptic protein known to form insoluble filamen- tous inclusions in Parkinson's disease (PD) and other neurodegenerative disorders. Various catecholamines can inhibit the α-Syn fibrillati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c6bb8683c9cfbbe159a40059b47fb11
https://doi.org/10.2174/1875039701003010001
https://doi.org/10.2174/1875039701003010001
Publikováno v:
Parkinson's Disease
Parkinson's Disease, Vol 2010 (2010)
Parkinson's Disease, Vol 2010 (2010)
α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. Currently, there is no approved therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a587d0a98b258fbeb416361608fdec
https://doi.org/10.4061/2010/650794
https://doi.org/10.4061/2010/650794