Výsledky vyhledávání - "Anthony K. W. Chan"

Akademický článek

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS pa

Externí odkaz: https://doaj.org/article/9ffe8e161f6f47b6ae292571819e0a78

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Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Publikováno v: Gut, 69(12), 2165-2179. BMJ Publishing Group

ObjectiveSporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.DesignWe established pair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f088e70976d8619feae560c7711a9e
https://doi.org/10.1136/gutjnl-2019-320019

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RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

Autor: Jeffrey C W Lai, Suet Yi Leung, Helen H.N. Yan, Siu Lun Ho, Janet F. Y. Lee, Alice H Y Man, Wai Yin Tsui, Annie S Y Chan, Siu Tsan Yuen, Bernard C H Lee, Wai K. Leung, Wai Lun Law, Hans Clevers, Sarah S K Yue, Anthony K W Chan

Publikováno v: Gut. BMJ Publishing Group

OBJECTIVE: Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI) due to MLH1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c66b88971dcf1658a9beec807a24e76
https://doi.org/10.1136/gutjnl-2016-311849

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Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

Publikováno v: Nature Genetics. 43:1219-1223

Gastric cancer is a heterogeneous disease with multiple environmental etiologies and alternative pathways of carcinogenesis. Beyond mutations in TP53, alterations in other genes or pathways account for only small subsets of the disease. We performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f6af4c01d6f1ebf11f44f83a84bd15
https://doi.org/10.1038/ng.982

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Abstract 1448: Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation

Autor: Annie S Y Chan, Helen H.N. Yan, Wai Yin Tsui, Siu Lun Ho, Jeffrey C W Lai, Suet Yi Leung, Anthony K W Chan, Siu Tsan Yuen

Publikováno v: Cancer Research. 77:1448-1448

Serrated polyps can arise in a sporadic or familial polyposis setting and predispose to colorectal cancer (CRC). Recently, we have identified RNF43 germline mutation in a family with Serrated Polyposis Syndrome (Yan et al, GUT 2016). The presence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad35268cbec67482319db15132b63e0a
https://doi.org/10.1158/1538-7445.am2017-1448

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Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

Publikováno v: Nature Genetics, 46(6), 573-82. Nature Publishing Group

Gastric cancer is a heterogeneous disease with diverse molecular and histological subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with DNA copy number, gene expression and methylation profiling, for integrative genomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9891cf3348bb955eb026d6415ee22468
https://pure.knaw.nl/portal/en/publications/6e80f981-c7a6-46fc-af6a-f440162cd896

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Abstract LB-380: Distinct methylation pattern in early-onset colorectal cancer patients without detectable germline mutation

Autor: Anthony K W Chan, Suet Yi Leung, Wendy Wy Tsui, Carmen Li, Tsun-leung Chan, S. T. Yuen, Annie Sy Chan

Publikováno v: Cancer Research. 72:LB-380

Colorectal cancer (CRC) is currently the second most common cancer and mortality rate of all cancers in Hong Kong. We have previously reported a higher incidence of early-onset colorectal cancer patients compare with other ethnic groups, which may be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb49ad7eddb7b2e77f23de884a1d06b8
https://doi.org/10.1158/1538-7445.am2012-lb-380

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