Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Anthony K N, Chan"'
Autor:
Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li, Kangqiang Qiu, Zhicong Zhao, Min Gao, Li Han, Anthony K. N. Chan, Wei Li, Keith Leung, Kitty Wang, Sheela Pangeni Pokharel, Ying Qing, Wei Liu, Xueer Wang, Lili Ren, Hongjie Bi, Lu Yang, Chao Shen, Zhenhua Chen, Laleh Melstrom, Hongzhi Li, Nikolai Timchenko, Xiaolan Deng, Wendong Huang, Steven T. Rosen, Jingyan Tian, Lin Xu, Jiajie Diao, Chun-Wei Chen, Jianjun Chen, Baiyong Shen, Hao Chen, Rui Su
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-24 (2024)
Abstract Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains elusive. We aim to c
Externí odkaz:
https://doaj.org/article/b8cac747695b48e59f1516ff7bd9a5a7
Autor:
Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen‐Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun‐Wei Chen
Publikováno v:
Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)
Abstract Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of epigenetics
Externí odkaz:
https://doaj.org/article/d8eb48a7527744de8eb5ea7136bf0bee
Autor:
Lu Yang, Anthony K. N. Chan, Kazuya Miyashita, Christopher D. Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A. Armstrong, Chun-Wei Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.
Externí odkaz:
https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c
Autor:
Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony K. N. Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis K. L. Chan, David S. C. Hui, Vincent C. T. Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, Wai-Lung Ng
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 792-802 (2021)
Externí odkaz:
https://doaj.org/article/c762182b6ed241e1a9a8500ceaadaf97
Autor:
Wai-Lung Ng, Ho-Chuen Li, Kit-Man Lau, Anthony K. N. Chan, Clara Bik-San Lau, Tony K. M. Shing
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Carbasugar sodium-glucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates for the treatment of Type 2 diabetes mellitus (T2DM). However, the clinical usage of carbasugar SGLT2 inhibitors has been underexplored, due to
Externí odkaz:
https://doaj.org/article/83f1c652d862439b94d28fde317fcb02
Autor:
Anthony K. N. Chan, Chun-Wei Chen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL or KMT2A) are highly prevalent in pediatric oncology. The poor survival rate and lack of an effective targeted therapy for patients with MLL-rearranged (MLL-r) leuk
Externí odkaz:
https://doaj.org/article/c79c3aa34021488fbc17b600c875921f
Autor:
Xiaobao Xu, Anthony K. N. Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E. Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T. Rosen, Jianjun Chen, Lu Yang, Chun-Wei Chen
Publikováno v:
Science Advances. 8
Epigenetic dysregulation of cell cycle is a hallmark of tumorigenesis in multiple cancers, including hepatocellular carcinoma (HCC). Nonetheless, the epigenetic mechanisms underlying the aberrant cell cycle signaling and therapeutic response remain u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ef1783629f1f0fa789c04c119416e5
https://doi.org/10.1126/sciadv.adc8911
https://doi.org/10.1126/sciadv.adc8911
Autor:
Anil Kumar, Anthony K. N. Chan, Qiao Liu, Sheela Pangeni Pokharel, Chun-Wei Chen, Srividya Swaminathan, Sung June Lee, Jianhua Yu
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 4, Pp 100874-(2021)
STAR Protocols, Vol 2, Iss 4, Pp 100874-(2021)
Summary Cytotoxic natural killer cells kill tumors and infected cells. We carried out CRISPR-based gene editing and transcriptional regulation in hard-to-manipulate NK-92 cells. NK-92-based therapies were found to be safe and efficacious in preclinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1833cca3a910cb968bd0387ee7983309
http://europepmc.org/articles/PMC8551845
http://europepmc.org/articles/PMC8551845
Autor:
Matthias Schiedel, Katrina H. Andrews, Corentine M.C. Laurin, Joseph P. Bluck, Stuart J. Conway, Prakriti Kalra, Panagis Filippakopoulos, James Clayton, Anthony K. N. Chan, Amy R. Scorah, Oleg Fedorov, Ester M. Hammond, Mustafa Moroglu, Kayla B. Vinh, William C. K. Pomerantz, Richard I. Cooper, Wilian A. Cortopassi, Pascal Heitel, Robert S. Paton, Anna Skwarska, Gabriella T. Perell, Kirsten E. Christensen, Larissa See, Hannah Bolland, Timothy P. C. Rooney, Sarah Picaud, Philip C. Biggin, Michael Brand
Publikováno v:
Journal of Medicinal Chemistry
CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development. They each comprise 10 domains through which they interact with >400 proteins, making them important transcriptional co-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e5b7850f0b3a5289c8056a1b4a57d6
https://pubmed.ncbi.nlm.nih.gov/34255515
https://pubmed.ncbi.nlm.nih.gov/34255515
Autor:
Ren-Jang Lin, Mingli Li, Qiao Liu, Anthony K. N. Chan, Chun-Wei Chen, Xiaobao Xu, Shao-Yuan Wang, Wen-Han Chang, Sheela Pangeni Pokharel, Kazuya Miyashita, Nicole Mattson, Lu Yang, Wei Lu
Publikováno v:
Leukemia. 36(1)
Sphingolipids and their metabolic pathways have been implicated in disease development and therapeutic response; however, the detailed mechanisms remain unclear. Using a sphingolipid network focused CRISPR/Cas9 library screen, we identified an endopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c9c4cf65e172553fde8dcee7dadc64
https://pubmed.ncbi.nlm.nih.gov/34373586
https://pubmed.ncbi.nlm.nih.gov/34373586