Effect of endothelium on the anticoagulant activity of a covalent antithrombin-heparin complex

Autor: Helen M. Atkinson, Ivan Stevic, Leslie R. Berry, Anthony K. C. Chan

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract We developed a covalent antithrombin-heparin complex (ATH) with superior In vivo anticoagulant efficacy compared to non-covalent antithrombin (AT) + unfractionated heparin (H). Previous in vitro studies of ATH, investigating the mechanisms b

Externí odkaz: https://doaj.org/article/17f930caa9094d43a8db70b52095bcd6

BAY 81-8973 Efficacy and Safety in Previously Untreated and Minimally Treated Children with Severe Hemophilia A: The LEOPOLD Kids Trial

Autor: Rolf Ljung, Anthony K. C. Chan, Heidi Glosli, Olubunmi Afonja, Bastian Becker, Despina Tseneklidou-Stoeter, Maria Elisa Mancuso, Sonata Saulyte-Trakymiene, Gili Kenet

Publikováno v: Thrombosis and Haemostasis. 123:027-039

Introduction BAY 81–8973, a full-length recombinant factor VIII for hemophilia A treatment, has been extensively evaluated in previously treated patients in the LEOPOLD (Long-Term Efficacy Open-Label Program in Severe Hemophilia A Disease) clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68aef4241eb0dc6c0d0234cea4eac6ad
https://doi.org/10.1055/s-0042-1757876

Childhood nephrotic syndrome and the clinical profile of thromboembolism: a systematic review and meta-analysis

Autor: Kayla Dadgar, Yuanxin Xue, Jason Chung, Stephanie Sangar, Mihir Bhatt, Anthony K. C. Chan, Hannah Geddie, Rahul Chanchlani

Publikováno v: Pediatric Research. 93:1463-1469

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de9e684b8f9317d38e31b9dc6d6a41c
https://doi.org/10.1038/s41390-022-02302-6

Development of decision-making considerations to support equitable patient selection in paediatric haemophilia trials

Autor: Anne Fu, Karen Strike, Korinne Hamilton, Linda Waterhouse, Kay Decker, Theresa Almonte, Anthony K C Chan

Publikováno v: The Journal of Haemophilia Practice. 9:41-49

Background Clinical trials for investigational haemophilia treatments such as gene therapy offer a potentially life-changing opportunity to those who are selected for enrolment. However, the number of enrolment slots available for these trials is oft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::238da86c8454a6d065a7a8ba4edfaf77
https://doi.org/10.2478/jhp-2022-0007

Quality of Life in Older Adults After Major Cancer Surgery: The GOSAFE International Study

Autor: Montroni, Isacco, Ugolini, Giampaolo, Saur, Nicole M, Rostoft, Siri, Spinelli, Antonino, Van Leeuwen, Barbara L, De Liguori Carino, Nicola, Ghignone, Federico, Jaklitsch, Michael T, Somasundar, Ponnandai, Garutti, Anna, Zingaretti, Chiara, Foca, Flavia, Vertogen, Bernadette, Nanni, Oriana, Wexner, Steven D, Audisio, Riccardo, A Giovanni Taffurelli, Davide, Zattoni, Paola, Tramelli, Giacomo, Sermonesi, Giorgio, Ercolani, Francesca, Tauceri, Barbara, Perenze, Daniela Di Pietrantonio, Mariateresa, Mirarchi, Gianluca, Garulli, Vincenzo, Alagna, Lucchi, Andrea, Basilio, Pirrera, Francesco, Monari, Luigi, Conti, Patrizio, Capelli, Andrea, Romboli, Gerardo, Palmieri, Filippo, Banchini, Francesca Di Candido, Michele, Carvello, Matteo, Sacchi, DE LUCIA, Francesca, Caterina, Foppa, Luigi, Marano, Spaziani, Alessandro, Giampaolo, Castagnoli, Bartoli, Alberto, Laura, Frain, Sam, W Fox, Kristin, Cardin, Luis, E De Leon, Mario, Trompetto, Gallo, Gaetano, Alberto Realis Luc, Giuseppe, Clerico, Giuseppe, Sammarco, Raffaele De Luca, Michele, Simone, Rocco, Lomonaco, Michael, Fejka, Joshua I, S Bleier, Matthijs, Plas, Hanneke van der Wal-Huisman, Andrea, Costanzi, Giulio, Mari, Dario, Maggioni, Pellegrino, Roberta, Pietro, Ascheri, Jakub, Kenig, Kinga, Szabat, Stefano, Scabini, Davide, Pertile, Lorenzo, Epis, Andrea, Massobrio, Domenico, Soriero, Arild, Nesbakken, Ingeborg Flåten Backe, Mariann, Lønn, Ferrari, Giovanni, Michele, Mazzola, Carmelo, Magistro, Pietro, Achilli, Alessandro, Giani, Orestis, Ioannidis, Lydia, Loutzidou, Konstantinos, Galanos-Demiris, Balducci, Genoveffa, Frezza, Barbara, Lucarini, Alessio, Claudia, Santos, Diogo, Cardoso, Isabela, Gil, Vasco, Cardoso, Lisa, Cooper, Baha, Siam, Yochai, Levy, Baruch, Brenner, Hanoch, Kashtan, Valerio, Belgrano, Franco, Decian, Beatrice, Palermo, Roberto, Eggenhöffner, Manuela, Albertelli, Luis, Sánchez-Guillén, Antonio, Arroyo, Francisco, López-Rodríguez, Sandra, Lario, DI LILLO, Cristina, Minas, Baltatzis, Anthony K, C Chan, Ajith, K Siriwardena, Giovanna Da Silva

Publikováno v: Journal of the National Cancer Institute, 114(7), 969-978. Oxford University Press

Background Accurate quality of life (QoL) data and functional results after cancer surgery are lacking for older patients. The international, multicenter Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery (GOSAFE) Study comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3fe9258ce0a1bc411997279e98c46a
https://research.rug.nl/en/publications/c4def213-e8cd-4f9c-8003-c3973ae1a77a