Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Anthony Joseph Hayes"'
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5583, p 5583 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 5583, p 5583 (2021)
Background. The extracellular matrix of the PNS/CNS is unusual in that it is dominated by glycosaminoglycans, especially hyaluronan, whose space filling and hydrating properties make essential contributions to the functional properties of this tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a1ba28ea135900207edd47ab943783
http://europepmc.org/articles/PMC8197505
http://europepmc.org/articles/PMC8197505
Autor:
Anthony Joseph Hayes, James Melrose
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4415, p 4415 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The recent discovery of nuclear and perinuclear perlecan in annulus fibrosus and nucleus pulposus cells and its known matrix stabilizing properties in tissues introduces the possibility that perlecan may also have intracellular stabilizing or regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d7a2b8bc982ffc0a1642407e244790
https://www.mdpi.com/1422-0067/22/9/4415
https://www.mdpi.com/1422-0067/22/9/4415
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2716, p 2716 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 2716, p 2716 (2021)
In this study, we review mechanoregulatory roles for perlecan in load-bearing connective tissues. Perlecan facilitates the co-acervation of tropoelastin and assembly of elastic microfibrils in translamellar cross-bridges which, together with fibrilli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddbc06799095d0450bbb61215a670a8
http://europepmc.org/articles/PMC7962540
http://europepmc.org/articles/PMC7962540
Computational models of cellular structures generally rely on simplifying approximations and assumptions that limit biological accuracy. This study presents a comprehensive image processing pipeline for creating unified three-dimensional (3D) reconst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7be4a8334b5705c6b72cbfda7a9f083
https://orca.cardiff.ac.uk/id/eprint/135508/1/jbio.202000202.pdf
https://orca.cardiff.ac.uk/id/eprint/135508/1/jbio.202000202.pdf
Publikováno v:
Proteoglycans in Stem Cells ISBN: 9783030734527
Chondroitin sulphate (CS) has essential roles to play in the stem cell niche with regard to stem cell differentiation and the attainment of pluripotency. The sulphation status of CS is an important determinant of its functional properties, and this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d15b26163f8d862fe56e1de36bc49a7c
https://doi.org/10.1007/978-3-030-73453-4_4
https://doi.org/10.1007/978-3-030-73453-4_4
Autor:
Anthony Joseph Hayes, James Melrose
Glycosaminoglycans (GAGs) are a family of diverse biomolecules that decorate proteoglycans in the glycocalyx and extracellular matrix of all cells. They exist as linear polysaccharide chains consisting of repeating disaccharide units that can be vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084ffb164c5fc98e790a78e935ba076b
Autor:
Anthony Joseph Hayes, James Melrose
Publikováno v:
Biomolecules, Vol 10, Iss 1244, p 1244 (2020)
Biomolecules
Biomolecules
This review examines aggrecan’s roles in developmental embryonic tissues, in tissues undergoing morphogenetic transition and in mature weight-bearing tissues. Aggrecan is a remarkably versatile and capable proteoglycan (PG) with diverse tissue cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba5507eb858970210d2b5e458c042f5
https://www.mdpi.com/2218-273X/10/9/1244
https://www.mdpi.com/2218-273X/10/9/1244
Autor:
Anthony Joseph Hayes, James Melrose
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030401450
Keratan sulphate (KS) is a bioactive glycosaminoglycan (GAG) of some complexity composed of the repeat disaccharide D-galactose β1→4 glycosidically linked to N-acetyl glucosamine. During the biosynthesis of KS, a family of glycosyltransferase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34967c7841cb93a4511f316318425923
Autor:
Anthony Joseph Hayes, James Melrose
Publikováno v:
Cells
Cells, Vol 9, Iss 826, p 826 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 826, p 826 (2020)
Volume 9
Issue 4
This study has identified keratan sulfate in fetal and adult rat spinal cord and vertebral connective tissues using the antibody BKS-1(+) which recognizes a reducing terminal N-acetyl glucosamine-6-sulfate neo-epitope exposed by keratanase-I digestio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89554a46edfaebd1d57c03ba6b771b5e
https://pubmed.ncbi.nlm.nih.gov/32235499
https://pubmed.ncbi.nlm.nih.gov/32235499
Autor:
Kazuyuki Sugahara, Anthony Joseph Hayes, Bruce Caterson, James Melrose, John M. Whitelock, Brooke L. Farrugia
Publikováno v:
Biochemical Journal. 475:587-620
Chondroitin sulphate glycosaminoglycan chains on cell and ECM proteoglycans can no longer be regarded as merely hydrodynamic space fillers. Overwhelming evidence over recent years indicates that sulphation motif sequences within the chondroitin sulph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271e39f05166bfd7617f99f3cb968318
https://doi.org/10.1042/bcj20170820
https://doi.org/10.1042/bcj20170820