Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Anthony J. Spychalla"'
Autor:
Keith A. Josephs, Joseph R. Duffy, Heather M. Clark, Rene L. Utianski, Edythe A. Strand, Mary M. Machulda, Hugo Botha, Peter R. Martin, Nha Trang Thu Pham, Julie Stierwalt, Farwa Ali, Marina Buciuc, Matthew Baker, Cristhoper H. Fernandez De Castro, Anthony J. Spychalla, Christopher G. Schwarz, Robert I. Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, Eileen H. Bigio, Ross R. Reichard, Eric. J. Polley, Nilufer Ertekin-Taner, Rosa Rademakers, Michael A. DeTure, Owen A. Ross, Dennis W. Dickson, Jennifer L. Whitwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Progressive apraxia of speech (PAOS) is a neurodegenerative syndrome of multiple etiologies which affects spoken communication. Here, the authors characterized the molecular pathology, biochemistry, genetics and longitudinal neuroimaging of 32 autops
Externí odkaz:
https://doaj.org/article/ed3e8ba520e446b7a84a4834659451e7
Autor:
Marina Buciuc, Peter R. Martin, Nirubol Tosakulwong, Melissa E. Murray, Leonard Petrucelli, Matthew L. Senjem, Anthony J. Spychalla, David S. Knopman, Bradley F. Boeve, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard, Dennis W. Dickson, Clifford R. Jack, Jr., Jennifer L. Whitwell, Keith A. Josephs
Publikováno v:
NeuroImage: Clinical, Vol 34, Iss , Pp 102954- (2022)
Transactive response DNA-binding protein of ∼43 kDa (TDP-43), a primary pathologic substrate in tau-negative frontotemporal lobar degeneration (FTLD), is also often found in the brains of elderly individuals without FTLD and is a key player in the
Externí odkaz:
https://doaj.org/article/80d4e6ff645549b4a0697e059a8988f6
Autor:
Christopher G. Schwarz, Walter K. Kremers, Heather J. Wiste, Jeffrey L. Gunter, Prashanthi Vemuri, Anthony J. Spychalla, Kejal Kantarci, Aaron P. Schultz, Reisa A. Sperling, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Jr.
Publikováno v:
NeuroImage, Vol 231, Iss , Pp 117845- (2021)
Recent advances in automated face recognition algorithms have increased the risk that de-identified research MRI scans may be re-identifiable by matching them to identified photographs using face recognition. A variety of software exist to de-face (r
Externí odkaz:
https://doaj.org/article/abc3b6ccb6c04cb49406f8dd4c62130f
Autor:
Irene Sintini, Peter R. Martin, Jonathan Graff-Radford, Matthew L. Senjem, Christopher G. Schwarz, Mary M. Machulda, Anthony J. Spychalla, Daniel A. Drubach, David S. Knopman, Ronald C. Petersen, Val J. Lowe, Clifford R. Jack, Jr, Keith A. Josephs, Jennifer L. Whitwell
Publikováno v:
NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)
The aims of this study were: to examine regional rates of change in tau-PET uptake and grey matter volume in atypical Alzheimer's disease (AD); to investigate the role of age in such changes; to describe multimodal regional relationships between tau
Externí odkaz:
https://doaj.org/article/77dd4b6064d4482dae2b4d05ac8404d8
Autor:
Nha Trang Thu Pham, Jonathan Graff Radford, Mary M. Machulda, Anthony J. Spychalla, Christopher G. Schwarz, Matthew L. Senjem, Val J. Lowe, Prashanthi Vemuri, Clifford R. Jack, Keith A Josephs, Jennifer L Whitwell
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Owen A. Ross, Cristhoper H. Fernandez De Castro, Farwa Ali, Nilufer Ertekin-Taner, Nha Trang Thu Pham, R. Ross Reichard, Val J. Lowe, Anthony J. Spychalla, Mary M. Machulda, Rosa Rademakers, Julie A.G. Stierwalt, Marina Buciuc, Joseph R. Duffy, Jennifer L. Whitwell, Michael DeTure, Clifford R. Jack, Keith A. Josephs, Christopher G. Schwarz, Robert I. Reid, Matthew L. Senjem, Rene L. Utianski, Peter R. Martin, Edythe A. Strand, Dennis W. Dickson, Eric. J. Polley, Hugo Botha, Matthew L. Baker, Heather M. Clark, Eileen H. Bigio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature communications
Nature Communications
Nature communications
Nature Communications
Progressive apraxia of speech is a neurodegenerative syndrome affecting spoken communication. Molecular pathology, biochemistry, genetics, and longitudinal imaging were investigated in 32 autopsy-confirmed patients with progressive apraxia of speech
Autor:
Dimitrios Kapogiannis, Anthony J. Spychalla, Keenan A. Walker, Carlos Nogueras-Ortiz, Clifford R. Jack, Josef Coresh, Rebecca F. Gottesman, Sahil Chawla, Dean F. Wong, A. Richey Sharrett
Publikováno v:
Neurobiol Aging
We used plasma neuronal extracellular vesicles to examine how neuronal insulin signaling proteins relate cross-sectionally to brain structure in nondemented older adults with varying levels of cortical amyloid. Extracellular vesicles enriched for neu
Autor:
Caterina Giannini, Jeffrey L. Gunter, Mary M. Machulda, Anthony J. Spychalla, Keith A. Josephs, Aditya Raghunathan, Jennifer L. Whitwell, Marina Buciuc, Joseph R. Duffy, Dennis W. Dickson, Clifford R. Jack
Publikováno v:
Eur J Neurol
Background and purpose: Cerebral microbleeds (MB) and superficial siderosis (SS) are frequent neuroimaging findings in patients with logopenic progressive aphasia (LPA), often with frontal lobe predilection. Cerebral amyloid angiopathy (CAA) is hypot
Autor:
Ronald C. Petersen, Clifford R. Jack, Jennifer L. Whitwell, Matthew L. Senjem, Keith A. Josephs, Stephen D. Weigand, Peter R. Martin, Joseph E. Parisi, Dennis W. Dickson, Melissa E. Murray, Nirubol Tosakulwong, David S. Knopman, Bradley F. Boeve, Anthony J. Spychalla, Leonard Petrucelli, Marina Buciuc
Publikováno v:
Brain
Alzheimer’s disease is characterized by the presence of amyloid-β and tau deposition in the brain, hippocampal atrophy and increased rates of hippocampal atrophy over time. Another protein, TAR DNA binding protein 43 (TDP-43) has been identified i
Autor:
Val J. Lowe, Matthew L. Senjem, Jon Graff-Radford, Christopher C. Schwarz, David S. Knopman, Joseph R. Duffy, Clifford R. Jack, Mary M. Machulda, Keith A. Josephs, Jennifer L. Whitwell, Joseph E. Parisi, Dennis W. Dickson, Anthony J. Spychalla, Ronald C. Petersen, Nirubol Tosakulwong, Bradley F. Boeve
Publikováno v:
Neurology
ObjectiveTo characterize longitudinal MRI and PET abnormalities in autopsy-confirmed Pick disease (PiD) and determine how patterns of neurodegeneration differ with respect to clinical syndrome.MethodsSeventeen patients with PiD were identified who ha