Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Anthony J. Slavin"'
Autor:
Lori Patnaude, Anthony J. Slavin, Louise K. Modis, Melissa Hill-Drzewi, Josh Horan, Sokol A. Haxhinasto, Susan Lukas
Publikováno v:
SLAS Discovery. 19:407-416
Sphingosine-1-phosphate (S1P) is a bioactive metabolite with pleiotropic effects on multiple cellular processes in health and disease. Responses elicited by S1P are a result of binding to five specific G-protein–coupled receptors. We have developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b583d75d74f31f9782fc6b7958455925
https://doi.org/10.1177/1087057113502234
https://doi.org/10.1177/1087057113502234
Autor:
Bradford L. McRae, Annette J. Schwartz Sterman, Terry Melim, Paul Peso, Anthony J. Slavin, Sam Karsen, Robert Dunstan, Kelly Creamer, Heather Knight, Valerie Pivorunas, Sarah Wilson, Kristen Legendre, Sonia Terrillon, Rajesh V. Kamath, Martha Mayo, Regina Mario, Susan V. Westmoreland, Lori Patnaude, Yingli Yang
Publikováno v:
Gastroenterology. 156:S-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b332783293f6494a9bcc71e63e6ae3e
https://doi.org/10.1016/s0016-5085(19)36871-4
https://doi.org/10.1016/s0016-5085(19)36871-4
Autor:
Jeanne M. Soos, Howard L. Weiner, Elizabeth K. Bikoff, Anthony J. Slavin, Scott S. Zamvil, Adriano Fontana, Olaf Stüve, Juan C. Patarroyo
The role of processing in antigen (Ag) presentation and T cell activation in experimental allergic encephalomyelitis (EAE) was evaluated in wild-type mice, mice that selectively express either Ii p31 or p41, and mice completely deficient in Ii or H-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22044fe6bc65dbdf871bf04fe5574c6a
https://ora.ox.ac.uk/objects/uuid:92c0e7b2-fe1f-4122-81c1-d6123b09591c
https://ora.ox.ac.uk/objects/uuid:92c0e7b2-fe1f-4122-81c1-d6123b09591c
Autor:
Thomas Prod'homme, Juan C. Patarroyo, Nicolas Molnarfi, Tara Karnezis, Scott S. Zamvil, Anthony J. Slavin, Christopher Linington, Claude C.A. Bernard, Klaus Lehmann-Horn, Jeffrey Eastham-Anderson, Flavius Martin, Martin S. Weber, Dimitry M. Danilenko
Publikováno v:
Annals of Neurology. 68:369-383
Objective Clinical studies indicate that anti-CD20 B cell depletion may be an effective multiple sclerosis therapy. We investigated mechanisms of its immune modulation using two paradigms of experimental autoimmune encephalomyelitis (EAE).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d911fb6575b9cdd7bc999f8acdd107d2
https://doi.org/10.1002/ana.22081
https://doi.org/10.1002/ana.22081
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 30:362-369
For a successful immune response, migration of lymphocytes to lymphoid organs and other tissues is a key step, as the initial recognition of foreign antigens and activation of lymphocytes takes place in these organs. CD62L is a homing receptor that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5b1b6f718f03f738482e4e3e4c3103
https://doi.org/10.1016/j.ejcts.2006.04.014
https://doi.org/10.1016/j.ejcts.2006.04.014
Autor:
Astrid Strelow, Timothy Hoey, Holger Wesche, Scott Powers, Jessica Orf, Anthony J. Slavin, Shyun Li, Minqing Rong, Ken Q. C. Nguyen, Lawrence Chinn, Yan Degenhardt, Edward H. van der Horst, Lei-Hoon See
Publikováno v:
Proceedings of the National Academy of Sciences. 102:15901-15906
Metastasis of primary tumors leads to a very poor prognosis for patients suffering from cancer. Although it is well established that not every tumor will eventually metastasize, it is less clear whether primary tumors acquire genetic alterations in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e1f8a12c6493944521e0017dd61dd7
https://doi.org/10.1073/pnas.0508014102
https://doi.org/10.1073/pnas.0508014102
Autor:
Songzhu An, Timothy Hoey, Neelam Srivastava, Wendy W. Zhong, Ming Yang, Jianxin Yang, Anthony J. Slavin
Publikováno v:
Proceedings of the National Academy of Sciences. 102:6027-6032
Recent studies suggest that lysophosphatidic acid (LPA) and its G protein-coupled receptors (GPCRs) LPA 1 , LPA 2 , or LPA 3 may play a role in the development of several types of cancers, including colorectal cancer. However, the specific receptor s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b384ac3395d5340aa108f35b07944b80
https://doi.org/10.1073/pnas.0501535102
https://doi.org/10.1073/pnas.0501535102
Autor:
Anthony J. Slavin, Bertram Reingruber, Roland S. Croner, Werner Hohenberger, Renate Siebenhaar, Christian Stremmel
Publikováno v:
International Journal of Colorectal Disease. 20:485-493
T cells of tumor-bearing mice or cancer patients exhibit an immune dysfunction, enabling the tumor to escape immune surveillance. The experiments are based on EL4 thymoma cells that were transfected with costimulatory ligands B7-1, B7-2, or both at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3cf0728c88f033d9e2903b61bd799c
https://doi.org/10.1007/s00384-004-0714-1
https://doi.org/10.1007/s00384-004-0714-1
Autor:
Thomas Prod'homme, Anthony J. Slavin, Lawrence Steinman, Shannon Dunn, Scott S. Zamvil, Sawsan Youssef, Olaf Stüve
Publikováno v:
Expert Opinion on Therapeutic Targets. 7:613-622
Multiple sclerosis (MS) is a CNS-demyelinating disease characterised by relapsing and chronic neurological impairment. While traditionally CNS autoantigen-specific CD4(+) T cells have been considered the culprits in the initial phase of the disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435e8994d0a179c7d5d6e5d91cb0fa1f
https://doi.org/10.1517/14728222.7.5.613
https://doi.org/10.1517/14728222.7.5.613
Publikováno v:
Proceedings of the National Academy of Sciences. 100:7803-7807
TASK3 gene (Kcnk9) is amplified and overexpressed in several types of human carcinomas. In this report, we demonstrate that a point mutation (G95E) within the consensus K+filter of TASK3 not only abolished TASK3 potassium channel activity but also ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e67be11be5b09180217ed247ae3323
https://doi.org/10.1073/pnas.1232448100
https://doi.org/10.1073/pnas.1232448100