Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Anthony J. Saporita"'
Autor:
Jason T. Forys, Catherine E. Kuzmicki, Anthony J. Saporita, Crystal L. Winkeler, Leonard B. Maggi, Jr., Jason D. Weber
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 514-526 (2014)
Summary: The ARF and p53 tumor suppressors are thought to act in a linear pathway to prevent cellular transformation in response to various oncogenic signals. Here, we show that loss of p53 leads to an increase in ARF protein levels, which function t
Externí odkaz:
https://doaj.org/article/eaa17c2fcc3c482b9fcfd53d0e85ad7e
Autor:
Jason D. Weber, Loren S. Michel, R. Reid Townsend, Jianbo Wang, Raleigh D. Kladney, Anthony J. Apicelli, Crystal L. Winkeler, Hsiang-Chun Chang, Anthony J. Saporita
PDF file - 2.8MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b73ac4a5f28e62c4b2427d0f5c3c8ab
https://doi.org/10.1158/0008-5472.22391376.v1
https://doi.org/10.1158/0008-5472.22391376.v1
Autor:
Jason D. Weber, Loren S. Michel, R. Reid Townsend, Jianbo Wang, Raleigh D. Kladney, Anthony J. Apicelli, Crystal L. Winkeler, Hsiang-Chun Chang, Anthony J. Saporita
The p19ARF tumor suppressor limits ribosome biogenesis and responds to hyperproliferative signals to activate the p53 checkpoint response. Although its activation of p53 has been well characterized, the role of ARF in restraining nucleolar ribosome p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91db42a5cf11bd0fdbd7c12c0b71478d
https://doi.org/10.1158/0008-5472.c.6503238.v1
https://doi.org/10.1158/0008-5472.c.6503238.v1
Autor:
Jason D. Weber, Loren S. Michel, R. Reid Townsend, Jianbo Wang, Raleigh D. Kladney, Anthony J. Apicelli, Crystal L. Winkeler, Hsiang-Chun Chang, Anthony J. Saporita
PDF file - 102K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927ab4f8c731acbbc14824cb19d5cffe
https://doi.org/10.1158/0008-5472.22391373.v1
https://doi.org/10.1158/0008-5472.22391373.v1
Autor:
Jason D. Weber, Loren S. Michel, R. Reid Townsend, Jianbo Wang, Raleigh D. Kladney, Anthony J. Apicelli, Crystal L. Winkeler, Hsiang-Chun Chang, Anthony J. Saporita
PDF file - 1.4MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffb0cfbcfc3cdf219231934c3ff0974
https://doi.org/10.1158/0008-5472.22391382.v1
https://doi.org/10.1158/0008-5472.22391382.v1
Publikováno v:
The Journal of Immunology. 208:46.18-46.18
Multiplex immunoassays are valuable research tools for studying circulating cytokines. Here we evaluate the ability of the MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A (Cat. No. HCYTA-60K) 48-plex immunoassay to reproducibly measure cyt
Publikováno v:
Cancer Research. 80:1453-1453
Ras proteins (HRAS, KRAS, and NRAS) are small GTPases that function as molecular switches by alternating between inactive GDP-bound and active GTP-bound states. Ras-GTP activates downstream pathways, including MAPK, by binding to Raf kinase and phosp
Publikováno v:
Molecular and Cellular Biology. 33:1594-1607
DHX33 is a pivotal DEAH-box RNA helicase in the multistep process of RNA polymerase I-directed transcription of the ribosomal DNA locus. We explored the regulation of DHX33 expression by Ras(V12) and ARF to determine DHX33's role in sensing these opp
Publikováno v:
Molecular and Cellular Biology. 32:348-364
The ARF tumor suppressor is a potent sensor of hyperproliferative cues emanating from oncogenic signaling. ARF responds to these cues by eliciting a cell cycle arrest, effectively abating the tumorigenic potential of these stimuli. Prior reports have
Autor:
Mark A. Watson, David G. Huntsman, John A. Olson, Sherri R. Davies, Melinda A. Miller, Anthony J. Saporita, Robert J. Crowder, Yu Tao, Chanpheng Phommaly, Jingqin Luo, Jason D. Weber, Jeremy Hoog, Li Lin, Joel S. Parker, Jacqueline E. Snider, Charles M. Perou, Matthew J. Ellis
Publikováno v:
Cancer Research. 69:3955-3962
Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to examine relationships between pharmacologic inhibition and somatic mutations in PI3K catalytic subunits in estrogen receptor