Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Anthony J. Sadler"'
Autor:
Lei Zhang, Li Jiang, Liang Yu, Qin Li, Xiangjun Tian, Jingquan He, Ling Zeng, Yuqin Yang, Chaoran Wang, Yuhan Wei, Xiaoyue Jiang, Jing Li, Xiaolu Ge, Qisheng Gu, Jikun Li, Di Wu, Anthony J. Sadler, Di Yu, Dakang Xu, Yue Gao, Xiangliang Yuan, Baokun He
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The metabolic environment of tumours has wide-ranging effects on the anti-tumour immune response and the outcome of immune therapy. Authors show here that the purine metabolite inosine enhances tumour immunogenicity and thus immune checkpoint blockad
Externí odkaz:
https://doaj.org/article/852722dd37b04979b5df24d84b26d42c
Autor:
Howard Chi Ho Yim, Arindam Chakrabarti, Sean Kessler, Hiroyuki Morimoto, Die Wang, Dhanya Sooraj, Afsar U. Ahmed, Carol de la Motte, Robert H. Silverman, Bryan RG. Williams, Anthony J. Sadler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Here we investigate the function of the innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role of PKR, we determine the physiological response to dextran sulfate sodium (DSS) of wild-type and two transge
Externí odkaz:
https://doaj.org/article/3eaa421f4b174f7085dd5a670e77412a
Autor:
Dakang Xu, Lisong Shen, Bryan R.G. Williams, Anthony J. Sadler, Jun-Ping Liu, Elizabeth D. Williams, Die Wang, Aaron T. Irving, Qiaohong Meng, Jianhua Chen, Liang Zhang, Tingting Rong, Guohua Xie, Junhua Li, Liang Yu, Xiangliang Yuan
PDF file - 752K, Table S1. ATF3 expression and clinicopathological findings in bladder cancer. Table S2. Relationship between ATF3 and GSN expression in bladder cancer. Table S3. Multivariate Cox proportional hazards regression for metastasis-free su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7498d26bd57772b7b6ed18a1d6d76dea
https://doi.org/10.1158/0008-5472.22397909.v1
https://doi.org/10.1158/0008-5472.22397909.v1
Autor:
Dakang Xu, Lisong Shen, Bryan R.G. Williams, Anthony J. Sadler, Jun-Ping Liu, Elizabeth D. Williams, Die Wang, Aaron T. Irving, Qiaohong Meng, Jianhua Chen, Liang Zhang, Tingting Rong, Guohua Xie, Junhua Li, Liang Yu, Xiangliang Yuan
Bladder cancer is associated with high recurrence and mortality rates due to metastasis. The elucidation of metastasis suppressors may offer therapeutic opportunities if their mechanisms of action can be elucidated and tractably exploited. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b604caca6afb91fca6466dc41a01fe
https://doi.org/10.1158/0008-5472.c.6504938
https://doi.org/10.1158/0008-5472.c.6504938
Autor:
Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frédéric Ebstein, Paul J. Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J. Calleja, Cassandra R. Harapas, Katherine R. Balka, Jacob Mitchell, Jacob T. Jackson, Niall D. Geoghegan, Fiona Moghaddas, Kelly L. Rogers, Katrin D. Mayer-Barber, Adriana A. De Jesus, Dominic De Nardo, Benjamin T. Kile, Anthony J. Sadler, M. Cecilia Poli, Elke Krüger, Raphaela Goldbach Mansky, Seth L. Masters
Publikováno v:
Science Immunology. 7
Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this is currently unknown. Here, we identified protein kinase R (PKR) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4eb9ee56088af3a11d074b259107a13
https://doi.org/10.1126/sciimmunol.abi6763
https://doi.org/10.1126/sciimmunol.abi6763
Autor:
Lei Zhang, Li Jiang, Liang Yu, Qin Li, Xiangjun Tian, Jingquan He, Ling Zeng, Yuqin Yang, Chaoran Wang, Yuhan Wei, Xiaoyue Jiang, Jing Li, Xiaolu Ge, Qisheng Gu, Jikun Li, Di Wu, Anthony J. Sadler, Di Yu, Dakang Xu, Yue Gao, Xiangliang Yuan, Baokun He
Publikováno v:
Nature communications. 13(1)
Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic adaptation, however, the mechanism is not fully known. Here we show, by m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a80d4f03197cc0113eca4a3fc93998c
https://pubmed.ncbi.nlm.nih.gov/36109526
https://pubmed.ncbi.nlm.nih.gov/36109526
Autor:
Anthony J. Sadler
Publikováno v:
Journal of Leukocyte Biology. 103:185-192
IFNs protect us against infection from viral pathogens, but can also induce damaging inflammation and are associated with the development of autoimmune conditions. By dissecting the response that is mediated by different IFN-regulated genes, we hoped
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213f9e1d695ec88745de84ececb385d1
https://doi.org/10.1189/jlb.4mr0617-223r
https://doi.org/10.1189/jlb.4mr0617-223r
Publikováno v:
PLoS Pathogens, Vol 5, Iss 2, p e1000311 (2009)
The double-stranded RNA-activated protein kinase R (PKR) is a key regulator of the innate immune response. Activation of PKR during viral infection culminates in phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 (
Externí odkaz:
https://doaj.org/article/49c1b7dca28d45f4ad332add2fd5a24f
Publikováno v:
ResearcherID
Melanoma differentiation‐associated protein 5 (MDA5) mediates the innate immune response to viral infection. Polymorphisms in IFIH1 , the gene coding for MDA5, correlate with the risk of developing type 1 diabetes (T1D). Here, we demonstrate that M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d1e0ad9827b31aec83b10944699601
https://doi.org/10.15252/embj.201696273
https://doi.org/10.15252/embj.201696273
Autor:
Die Wang, Pieter W. Faber, Liang Yu, Anthony J. Sadler, Christine L. White, Bryan R.G. Williams, Howard C.H. Yim
Publikováno v:
Cell Research. 26:367-379
The protein kinase R (PKR) functions in the antiviral response by controlling protein translation and inflammatory cell signaling pathways. We generated a transgenic, knock-in mouse in which the endogenous PKR is expressed with a point mutation that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001fbe9d1f2959ac4ffdd4f0222d2898
https://doi.org/10.1038/cr.2016.11
https://doi.org/10.1038/cr.2016.11