Výsledky vyhledávání - "Anthony J. Raffo"

Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists

Autor: Shi-Xian Deng, Anthony J. Raffo, Donald W. Landry, Paul L. Harris, Masanori Ichise, Yuli Xie

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:5111-5114

Vesicular monoamine transporter type 2 (VMAT2) is a newly emerging target for both diagnostic and therapeutic applications in diabetes mellitus. In pursuit of novel VMAT2 antagonists, we identified a potent hypoglycemic agent with a novel dihydropyri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc82bc066cff4c9902d9992297b402fa
https://doi.org/10.1016/j.bmcl.2008.07.129

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Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine

Autor: Mark A. Hardy, Anthony J. Raffo, Robin Goland, Teresa Polito, Caterina Ferrara, Pasquale Barba, Piotr Witkowski, Antonella Maffei, Rudolph L. Leibel, Ian R. Sweet, Matthew Freeby, Gordon Andan, Yuli Xie, Paul L. Harris, Kolbe Hancock

Publikováno v: Journal of Endocrinology 198 (2008): 41–49. doi:10.1677/JOE-07-0632
info:cnr-pdr/source/autori:Raffo, Anthony; Hancock, Kolbe; Polito, Teresa; Xie, Yuli; Andan, Gordon; Witkowski, Piotr; Hardy, Mark; Barba, Pasquale; Ferrara, Caterina; Maffei, Antonella; Freeby, Matthew; Goland, Robin; Leibel, Rudolph L.; Sweet, Ian R.; Harris, Paul E./titolo:Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine/doi:10.1677%2FJOE-07-0632/rivista:Journal of Endocrinology/anno:2008/pagina_da:41/pagina_a:49/intervallo_pagine:41–49/volume:198

Despite different embryological origins, islet β-cells and neurons share the expression of many genes and display multiple functional similarities. One shared gene product, vesicular monoamine transporter type 2 (VMAT2, also known as SLC18A2), is hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850bf2b4465af85e82f8d39b998a6ba7
https://doi.org/10.1677/joe-07-0632

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Magnetic Resonance Imaging of Major Histocompatibility Class II Expression in the Renal Medulla Using Immunotargeted Superparamagnetic Iron Oxide Nanoparticles

Autor: Truman R. Brown, Anthony J. Raffo, Kristi Hultman, Adrienne Grzenda, Paul L. Harris, Stephen O'Brien

Publikováno v: ACS Nano. 2:477-484

We demonstrate the development and successful application of immunotargeted superparamagnetic iron oxide nanoparticles (ITSIONs), with in vivo magnetic resonance diagnostic and potential drug delivery capability for kidney disease. Further, the versa

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https://doi.org/10.1021/nn700400h

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CHEMOSENSITIZATION OF BLADDER CARCINOMA CELLS BY BCL-xL ANTISENSE OLIGONUCLEOTIDES

Autor: C. A. Stein, Joshua Ojwang, Irina V. Lebedeva, Robert R. Rando, Anthony J. Raffo, Paul A. Cossum

Publikováno v: Journal of Urology. 166:461-469

Purpose: We investigated antisense inhibition of anti-apoptotic bcl-xL and bcl-2 proteins to increase chemosensitization in the T24 and 5637 bladder carcinoma cell lines.Materials and Methods: A T24 bladder carcinoma cell line stably over expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bfc3f89edc7c11f83af64b84cbae198
https://doi.org/10.1016/s0022-5347(05)65964-2

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Sustained Activation of Extracellular Signal-Regulated Kinase (ERK) Signaling in Human Prostate Cancer LNCaP Cells Depleted of Androgen

Autor: Robert L. Fine, Daniel P. Petrylak, Anthony J. Raffo, Lisa Drew

Publikováno v: The Prostate Journal. 3:105-117

Objectives: The mitogen-activated protein kinase (MAPK) cascade is involved in the control of cell growth and differentiation. In this study, we have investigated the effect of androgen withdrawal on this pathway and its potential role in the inducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57660e7f7111e19d3379f1d375932026
https://doi.org/10.1046/j.1525-1411.2001.32003.x

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Conformational and Molecular Basis for Induction of Apoptosis by a p53 C-terminal Peptide in Human Cancer Cells

Autor: Anthony J. Raffo, Patricio Abarzua, Regina Monaco, Arianna L. Kim, Matthew R. Pincus, Paul W. Brandt-Rauf, Robert L. Fine

Publikováno v: Journal of Biological Chemistry. 274:34924-34931

A p53-derived C-terminal peptide induced rapid apoptosis in breast cancer cell lines carrying endogenous p53 mutations or overexpressed wild-type (wt) p53 but was not toxic to nonmalignant human cell lines containing wt p53. Apoptosis occurred throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4066b2fafebcc314f759bd36c65b280d
https://doi.org/10.1074/jbc.274.49.34924

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Preoperative Reverse Transcriptase Polymerase Chain Reaction for Prostate Specific Antigen Predicts Treatment Failure Following Radical Prostatectomy

Autor: Anthony J. Raffo, Kathleen O'Toole, Glen M. de Vries, Carl A. Olsson, Mitchell C. Benson, Ralph Buttyan, Yichen Cao, Aaron E. Katz

Publikováno v: The Journal of Urology. :1557-1562

Purpose: We previously demonstrated than an enhanced reverse transcriptase-polymerase chain reaction assay for prostate specific antigen (PSA) can predict final pathological stage in radical prostatectomy patients. The potential role of the assay in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850226a49ad8378ac48d723dd736e6f8
https://doi.org/10.1097/00005392-199605000-00004

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Molecular Stating of Prostate Cancer. II. A Comparison of the Application of an Enhanced Reverse Transcriptase Polymerase Chain Reaction Assay for Prostate Specific Antigen Versus Prostate Specific Membrane Antigen

Autor: Aaron E. Katz, Carl A. Olsson, Anthony J. Raffo, Donald J. McMahon, Harris Perlman, Cristoforo Cama, Mitchell C. Benson, Ralph Buttyan

Publikováno v: Journal of Urology. 153:1373-1378

Current imaging modalities used to stage prostate cancer clinically fail to detect extracapsular disease in a significant subset of patients. A molecular based peripheral blood assay using the reverse transcriptase polymerase chain reaction has recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb96fa126982289ac5e29f19741d926d
https://doi.org/10.1016/s0022-5347(01)67407-x

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Enhanced reverse transcriptase-polymerase chain reaction for prostate specific antigen as an indicator of true pathologic stage in patients with prostate cancer

Autor: Cristoforo Cama, Melissa D. Begg, Ralph Buttyan, Aaron E. Katz, Anthony J. Raffo, Mitchell C. Benson, Glen M. de Vries, Kathleen O'Toole, Carl A. Olsson

Publikováno v: Cancer. 75:1642-1648

Background. As up to 50% of all patients with prostate cancer who have undergone radical prostatectomy are found to be understaged subsequent to surgery, a more sensitive early staging modality currently is needed. A molecular assay that detects pros

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https://doi.org/10.1002/1097-0142(19950401)75:7<1642::aid-cncr2820750714>3.0.co

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ChemInform Abstract: Novel Hypoglycemic Dihydropyridones Serendipitously Discovered from O- versus C-Alkylation in the Synthesis of VMAT2 Antagonists

Autor: Donald W. Landry, Masanori Ichise, Anthony J. Raffo, Shi-Xian Deng, Paul L. Harris, Yuli Xie

Publikováno v: ChemInform. 40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f4a9e95e2a71626fb4b80cfc12af79
https://doi.org/10.1002/chin.200905147

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