Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Anthony J. Pellerite"'
Autor:
Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero, Dominic J. Smiraglia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP s
Externí odkaz:
https://doaj.org/article/e67ec780a1554759a4b84c3b9ee77ce5
Autor:
Barbara A. Foster, Robert A. Casero, Mikhail A. Nikiforov, Anna Bianchi-Smiraglia, Gissou Azabdaftari, Mark D. Long, Hayley C. Affronti, Roberto Pili, Ellen Karasik, Justine J. Jacobi, Anthony J. Pellerite, Michael T. Moser, Kristopher Attwood, Dominic J. Smiraglia, Bryan Gillard, John Wilton, Aryn M. Rowsam, James G. Phillips, Christoph S. Boerlin, Spencer Rosario
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Prostatic luminal epithelial cells secrete high levels of acetylated polyamines into the prostatic lumen, sensitizing them to perturbations of connected metabolic pathways. Enhanced flux is driven by spermidine/spermine N1-acetyltransferase (SSAT) ac
Autor:
Christoph S. Boerlin, Hayley C. Affronti, Roberto Pili, Spencer Rosario, Kristopher Attwood, Barbara A. Foster, Mark D. Long, Ellen Karasik, John Wilton, Anthony J. Pellerite, Dominic J. Smiraglia, Moray J. Campbell, Bryan Gillard
Publikováno v:
Oncotarget
Folate impacts the genome and epigenome by feeding into one-carbon metabolism to produce critical metabolites, deoxythymidine monophosphate and s-adenosylmethionine. The impact of folate exposure and intervention timing on cancer progression remains
Autor:
Dominic J. Smiraglia, James G. Phillips, Aryn M. Rowsam, Hayley C. Affronti, Anthony J. Pellerite, Robert A. Casero, Mikhail A. Nikiforov, Spencer Rosario
Publikováno v:
Cancer Research. 78:B052-B052
Prostatic epithelial cells secrete high levels of acetylated polyamines into the prostatic lumen. This distinctive characteristic places added strain on connected pathways, forcing increased metabolite production from both one-carbon metabolism and t