Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Anthony J. Morgan"'
Autor:
Paul Fineran, Emyr Lloyd-Evans, Nathan A. Lack, Nick Platt, Lianne C. Davis, Anthony J. Morgan, Doris Höglinger, Raju Venkata V. Tatituri, Simon Clark, Ian M. Williams, Patricia Tynan, Nada Al Eisa, Evgeniya Nazarova, Ann Williams, Antony Galione, Daniel S. Ory, Gurdyal S. Besra, David G. Russell, Michael B. Brenner, Edith Sim, Frances M. Platt
Publikováno v:
Wellcome Open Research, Vol 1 (2017)
Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host c
Externí odkaz:
https://doaj.org/article/14691c8505704db9a2e77b48b84d36f2
Autor:
Paul Fineran, Emyr Lloyd-Evans, Nathan A. Lack, Nick Platt, Lianne C. Davis, Anthony J. Morgan, Doris Höglinger, Raju Venkata V. Tatituri, Simon Clark, Ian M. Williams, Patricia Tynan, Nada Al Eisa, Evgeniya Nazarova, Ann Williams, Antony Galione, Daniel S. Ory, Gurdyal S. Besra, David G. Russell, Michael B. Brenner, Edith Sim, Frances M. Platt
Publikováno v:
Wellcome Open Research, Vol 1 (2016)
Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host c
Externí odkaz:
https://doaj.org/article/6b137bbdd4a0445c9a31d3854f892721
Publikováno v:
Biochemical Society Transactions. 50:1143-1155
In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P2, TPCs are an integral part of fundamental signal-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8542cd0f9bb42d09fe08e0aeda7b8fc9
https://doi.org/10.1042/bst20220229
https://doi.org/10.1042/bst20220229
Publikováno v:
Handbook of experimental pharmacology.
The discovery of NAADP-evoked Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d658f9f2ab4e52516f0117d73746b448
https://pubmed.ncbi.nlm.nih.gov/35879580
https://pubmed.ncbi.nlm.nih.gov/35879580
The emergence of endo-lysosomes as ubiquitous Ca2+stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2370c9ac3606f3dfb276a6e0ee00e5c
https://ora.ox.ac.uk/objects/uuid:378b2814-de0c-492b-a565-89a7543ff586
https://ora.ox.ac.uk/objects/uuid:378b2814-de0c-492b-a565-89a7543ff586
Publikováno v:
Cell calcium. 101
Acidic organelles act as intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::239b57817e7d75480fe0b1b439270229
https://pubmed.ncbi.nlm.nih.gov/34922066
https://pubmed.ncbi.nlm.nih.gov/34922066
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1868(7)
The emergence of endo-lysosomes as ubiquitous Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09ef57cab5fc350fe71d0896a3403af2
https://pubmed.ncbi.nlm.nih.gov/33872669
https://pubmed.ncbi.nlm.nih.gov/33872669
Macrophages clear pathogens by phagocytosis and lysosomes that fuse with phagosomes are traditionally regarded as to a source of membranes and luminal degradative enzymes. Here, we reveal that endo‐lysosomes act as platforms for a new phagocytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab81ea67d8bb6db6a02fe7c9f3f34297
https://doi.org/10.15252/embj.2019104058
https://doi.org/10.15252/embj.2019104058
Publikováno v:
The EMBO Journal
Macrophages clear pathogens by phagocytosis and lysosomes that fuse with phagosomes are traditionally regarded as to a source of membranes and luminal degradative enzymes. Here, we reveal that endo‐lysosomes act as platforms for a new phagocytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0855e57b5bc3c36e4aad70283059c034
https://pubmed.ncbi.nlm.nih.gov/32510172
https://pubmed.ncbi.nlm.nih.gov/32510172
Publikováno v:
Cell calcium. 86
Lysosomotropic agents have been used to permeabilize lysosomes and thereby implicate these organelles in diverse cellular processes. Since lysosomes are Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::931e9fe6c23d6719c151d85c7e0726d8
https://pubmed.ncbi.nlm.nih.gov/31881482
https://pubmed.ncbi.nlm.nih.gov/31881482