Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Anthony J. Lawrence"'
Publikováno v:
Organic & Biomolecular Chemistry. 20:2661-2670
The observation of ready deprotonation of the phenylogous enol of benzodifurantrione (BDT) to give a bright violet conjugate base has led to two follow up explorations. Extension of BDT enol by insertion of a p-phenylene unit into the enol C-O bond g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d348502a66f07716a8940a78a022d328
https://doi.org/10.1039/d1ob02442f
https://doi.org/10.1039/d1ob02442f
Publikováno v:
The Journal of Organic Chemistry. 75:690-701
The first example of a stable phenylogous enol, resulting from an extended keto-enol tautomerization across a benzene ring, is described. The enol has been isolated, and its structure was proven by X-ray crystallography. The equilibrium between the k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0617f06018bb3e3c5a990919cdc424bd
https://doi.org/10.1021/jo9022155
https://doi.org/10.1021/jo9022155
Publikováno v:
Org. Biomol. Chem.. 2:869-875
The 5'-triphosphates of 2'-hydroxymethyluridine (2'-homouridine) and 2'-hydroxyethyluridine were prepared from the corresponding acetyl-protected nucleosides by initial phosphitylation with 2-chloro-5,6-benzo-1,2,3-dioxaphosphorin-4-one. 2'-Acetamido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81b392830a269a6965eec173a103a89
https://doi.org/10.1039/b314348a
https://doi.org/10.1039/b314348a
Autor:
Paul D. Lawrence, F. Yasmin Kazi, Mathis O. Riehle, Anthony J. Lawrence, Barbara M. Orr, John Young, Nicholas C. Price, James Sinclair, Julia MacDonald-Fyall, Roger Parton, John G. Coote
Publikováno v:
Journal of Biological Chemistry. 277:22289-22296
Continuous recording of the activity of recombinant adenylate cyclase (CyaA) of Bordetella pertussis (EC 4.6.1.1) by conductimetric determination of enzyme-coupled pyrophosphate cleavage has enabled us to define a number of novel features of the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cc7e41fa69a15413e58f08eba236c7
https://doi.org/10.1074/jbc.m106701200
https://doi.org/10.1074/jbc.m106701200
Publikováno v:
Journal of Biochemistry. 127:871-875
The acidic isoform of phospholipase A(2) from Naja mossambica mossambica was activated by treatment with a molar equivalent of oleoyl imidazolide. Modification of the protein was accompanied by 50% quenching of tryptophan fluorescence and a significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea4ac12f43c2358567a09669de98fb6
https://doi.org/10.1093/oxfordjournals.jbchem.a022681
https://doi.org/10.1093/oxfordjournals.jbchem.a022681
Autor:
Bernard P. Leung, R.D. Stevenson, Darryl J. Pappin, Andrew G. MacLean, Iain B. McInnes, John Young, Anthony J. Lawrence, Benito Cañas
Publikováno v:
Nature Medicine. 5:1424-1427
The possibility that glucocorticoids upregulate the expression of anti-inflammatory mediators is an exciting prospect for therapy in inflammatory diseases, because these molecules could give the therapeutic benefits of steroids without toxic side eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d68a18af34a5c24eca70ae503c863a7
https://doi.org/10.1038/71002
https://doi.org/10.1038/71002
Publikováno v:
Tetrahedron Letters. 39:6967-6970
An efficient route to 2′-homouridine ( 1 ), a new nucleoside analogue, is reported that is based on an ene reaction. This nucleoside has been incorporated into a dinucleoside monophosphate and hydrolytic studies on the dimer show that it does not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261177661f62c7af295a8c7ddee46b28
https://doi.org/10.1016/s0040-4039(98)01478-6
https://doi.org/10.1016/s0040-4039(98)01478-6
Publikováno v:
Biochemical Education. 26:56-62
Kinetic conductivity measurement, run as a microcomputer-controlled workstation with eight independent reaction cells, is shown here to be a simple, cost-effective method for assaying enzymes. The technique is demonstrated with enzymes that can be us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c98977cf8494a8ee2f6fb20d72616f29
https://doi.org/10.1016/s0307-4412(97)00129-5
https://doi.org/10.1016/s0307-4412(97)00129-5
Publikováno v:
Nucleosides and Nucleotides. 16:1497-1501
Five 2′-C-functionalized nucleosides (1–5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extrem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22569388ab97048b297c0b8e4770251b
https://doi.org/10.1080/07328319708006215
https://doi.org/10.1080/07328319708006215
Autor:
Julie Fisher, Mai-Yee Chan, Stephen Paul Collingwood, Robin Alec Fairhurst, John B. J. Pavey, Richard Cosstick, Anthony J. Lawrence, Ian A. O'Neil
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2761-2768
Uridine 2′-C-3′-O-γ-butyrolactone 5a has been prepared by cyclisation of 2′-α-C-carboxymethyl-2′-deoxyuridine 8 in acetic acid–methanol. Detailed 1H NMR studies on compound 5a clearly demonstrate cis fusion between the γ-lactone and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfff353eba09f0a3964a57752764cb23
https://doi.org/10.1039/a702088k
https://doi.org/10.1039/a702088k