Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anthony J. Galati"'
Autor:
David Warshawsky, Marlene Jaeger, Liang You, Gary D. Stoner, Anthony J. Galati, Glenn Talaska, Tyrone Collins
Publikováno v:
Carcinogenesis. 17:865-871
N-Heterocyclic polynuclear aromatic hydrocarbons (NHA) are environmental pollutants formed during the combustion of organic materials. 7-H-Dibenzo[c,g]carbazole (DBC) is a potent carcinogen in lung, liver and skin. We undertook these studies to deter
Autor:
Marc J. Mass, Garret B. Nelson, Anthony J. Galati, Amal Abu-Shakra, Barbara C. Roop, Gary D. Stoner, Stephen Nesnow, Jeffrey A. Ross
Publikováno v:
Carcinogenesis. 17:1701-1704
The polycyclic aromatic hydrocarbon benzo[b]fluoranthene (B[b]F) is a pervasive constituent of environmental combustion products. We sought to examine the lung tumorigenic activity of B[b]F in strain A/J mice, to study the relationship between format
Autor:
Anthony J. Galati, Jason C. Stoner, Garret B. Nelson, Jeffrey A. Ross, Shantu Amin, Gary D. Stoner, Stephen Nesnow, Marc J. Mass, Liang You, Dian Wang, Katrina H. Wilson
Publikováno v:
Carcinogenesis. 15:2613-2618
This study was undertaken to evaluate the carcinogenic potential of 5-methylchrysene (5-MeC) in strain A/J mouse lung and to correlate the 5-MeC-DNA adduct profile in lung tissue with the mutation spectrum in the K-ras gene of lung tumors. Strain A/J
Autor:
Avram Gold, Garret B. Nelson, Ramiah Sangaiah, Katrina H. Wilson, Barbara C. Roop, Stephen Nesnow, Anita J. Jeffers, Jeffrey A. Ross, Marc J. Mass, Gary D. Stoner, Anthony J. Galati
Publikováno v:
Carcinogenesis. 15:601-606
Cyclopenta[cd]pyrene (CPP) is a ubiquitous cyclopenta-fused polycyclic aromatic hydrocarbon. CPP is highly genotoxic in bacterial and mammalian systems inducing gene mutations, sister chromatid exchanges and morphological transformation. CPP is a mou
Publikováno v:
Cancer Letters. 72:103-110
The purpose of this investigation was to establish a dose response for the effects of dietary phenethyl isothiocyanate (PEITC) on N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis and DNA methylation. Groups of 13-27 rats were random
Autor:
Marc J. Mass, Garret B. Nelson, Gary D. Stoner, Anita J. Jeffers, Stephen Nesnow, Anthony J. Galati, Jeffrey A. Ross
Publikováno v:
Molecular Carcinogenesis. 8:186-192
Strain A/J mice received intraperitoneal injections of benz[j]aceanthrylene (B[j]A) or benzo[a]pyrene (B[a]P). At 24, 48, and 72 h, lung tissues were removed for analysis of B[a]P- or B[j]A-derived DNA adduct formation during the first 3 d of exposur
Autor:
Marc J. Mass, Brenda I. Gerwin, Gary D. Stoner, Anthony J. Galati, Simone E. Salghetti, Ih-Chang Hsu, Roger R. Reddel, Angela N. A. Somers, William T. Gunning, Curtis C. Harris, Bharati Hukku
Publikováno v:
International Journal of Cancer. 48:764-773
Bronchial epithelial cells were cultured from an individual with no evidence of malignant disease. These cells, designated HB56B, had a greatly extended in vitro life-span, being able to undergo 50 passages and 200 population doublings in contrast to
Publikováno v:
Archives of toxicology. 73(3)
CI-994 (acetyldinaline) is an investigative oral anticancer drug currently in clinical trials. To characterize the effects of CI-994 on lymphoid tissue, male rats were administered single oral doses at 0 (vehicle control), 10, 23, and 45 mg/kg and ki
Publikováno v:
Toxicology in Vitro. 3:21-25
One method of assessing the genotoxic effects of exposure to environmental agents is by determining the frequency of sister chromatid exchanges in exposed cells. In the present study, a procedure for observing sister chromatid exchanges in adult huma
Publikováno v:
Carcinogenesis. 9:1313-1316
The effect of ellagic acid (EA), a naturally occurring plant phenol, on the metabolism, DNA binding and DNA adduct formation of N-nitrosobenzylmethylamine (NBMA) in cultured explants of rat esophagus was investigated. Explants were incubated in mediu