Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration

Autor: Stephen M. Richardson, Francesca E. Ludwinski, Kanna K. Gnanalingham, Ross A. Atkinson, Anthony J. Freemont, Judith A. Hoyland

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstrates substantial changes in cell and matrix composition with both ageing and degeneration. While recent transcriptomic profiling studies have helped define human NP cell phen

Externí odkaz: https://doaj.org/article/6bd7742895a34ed49e2da4e7232f0efb

Responsive Nanogel Probe for Ratiometric Fluorescent Sensing of pH and Strain in Hydrogels

Autor: Mingning, Zhu, Dongdong, Lu, Shanglin, Wu, Qing, Lian, Wenkai, Wang, Amir H, Milani, Zhengxing, Cui, Nam T, Nguyen, Mu, Chen, L Andrew, Lyon, Daman J, Adlam, Anthony J, Freemont, Judith A, Hoyland, Brian R, Saunders

Publikováno v: ACS macro letters. 6(11)

In this study a new pH-responsive nanogel probe containing a complementary nonradiative resonance energy transfer (NRET) fluorophore pair is investigated and its ability to act as a versatile probe of network-related changes in three hydrogels demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54734d5d5720172e59117f2540f429bd
https://pubmed.ncbi.nlm.nih.gov/35650778

Multiple primary malignancies associated with a germline SMARCB1 pathogenic variant

Autor: Patrick Shenjere, Richard W. Whitehouse, Naomi L. Bowers, James P Wylie, Judith Eelloo, Noel W. Clarke, Miriam J. Smith, D. Gareth Evans, Anthony J. Freemont, Chris Duff, Calvin Soh, Paul Hulse, John Ealing, Mark Jones

Publikováno v: Eelloo, J, Smith, M J, Bowers, N, Ealing, J, Hulse, P, Wylie, J, Shenjere, P, Clarke, N, Soh, C, Whitehouse, R, Jones, M, Duff, C J, Freemont, T & Evans, D G 2019, ' Multiple primary malignancies associated with a germline SMARCB1 pathogenic variant ', Familial Cancer . https://doi.org/10.1007/s10689-019-00138-4

A 51-year old presented with a 6-month history of increasing pelvic/lower back pain with nocturnal waking and episodes of anorexia and vomiting. Examination revealed right torticollis and Horner’s syndrome, and a large abdominal mass arising from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9808eabe966e67c37c5ed86b9d507cf4
https://doi.org/10.1007/s10689-019-00138-4

Degenerate human nucleus pulposus cells promote neurite outgrowth in neural cells.

Autor: Stephen M Richardson, Devina Purmessur, Pauline Baird, Ben Probyn, Anthony J Freemont, Judith A Hoyland

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47735 (2012)

Innervation of nociceptive nerve fibres into the normally aneural nucleus pulposus (NP) of the intervertebral disc (IVD) occurs during degeneration resulting in discogenic back pain. The neurotrophins nerve growth factor (NGF) and brain-derived neuro

Externí odkaz: https://doaj.org/article/d81ec7a5f1df4cb7bbdf66df5a025efc

Histological ageing of fractures in infants: a practical algorithm for assessing infants suspected of accidental or non-accidental injury

Autor: Anie Naqvi, Emma Raynor, Anthony J. Freemont

Publikováno v: Histopathology
Naqvi, A, Raynor, E & Freemont, A J 2019, ' Histological Aging of Fractures in Infants: a practical algorithm for assessing infants suspected of accidental or non-accidental injury ', Histopathology . https://doi.org/10.1111/his.13850

Aims This study is the first to systematically document histological features of fractures of known age in infants (≦12 months). It has been used to develop a tabulated database specifically to guide histopathologists to age fractures in children c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118f6cd7e041160fd04969b24ef32cd7
https://pubmed.ncbi.nlm.nih.gov/30820979