Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anthony J. Covarrubias"'
Autor:
Sarah J. Shemtov, Rohini Emani, Olga Bielska, Anthony J. Covarrubias, Eric Verdin, Julie K. Andersen, Daniel A. Winer
Publikováno v:
The FEBS Journal.
Obesity and ageing predispose to numerous, yet overlapping chronic diseases. For example, metabolic abnormalities, including insulin resistance (IR) and type 2 diabetes (T2D) are important causes of morbidity and mortality. Low-grade chronic inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b5024438c7c52c6e0d9757613f6d9a
https://doi.org/10.1111/febs.16558
https://doi.org/10.1111/febs.16558
Publikováno v:
Nat Rev Mol Cell Biol
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcc022936aab4cfe7a4bdf29bdd6950
https://doi.org/10.1038/s41580-020-00313-x
https://doi.org/10.1038/s41580-020-00313-x
Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
Autor:
Anthony J Covarrubias, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, Issam Ben-Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul, Erika C Espinosa, Dudley Lamming, Brendan D Manning, Yijing Zhang, Ian A Blair, Tiffany Horng
Publikováno v:
eLife, Vol 5 (2016)
Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activatio
Externí odkaz:
https://doaj.org/article/1fb4cb2ef3724ea48f5af2d16ace1170
Autor:
Indra Heckenbach, Garik V. Mkrtchyan, Michael Ben Ezra, Daniela Bakula, Jakob Sture Madsen, Malte Hasle Nielsen, Denise Oró, Brenna Osborne, Anthony J Covarrubias, M. Laura Idda, Myriam Gorospe, Laust Mortensen, Eric Verdin, Rudi Westendorp, Morten Scheibye-Knudsen
Publikováno v:
Heckenbach, I, Mkrtchyan, G V, Ezra, M B, Bakula, D, Madsen, J S, Nielsen, M H, Oró, D, Osborne, B, Covarrubias, A J, Idda, M L, Gorospe, M, Mortensen, L, Verdin, E, Westendorp, R & Scheibye-Knudsen, M 2022, ' Nuclear morphology is a deep learning biomarker of cellular senescence ', Nature Aging, vol. 2, no. 8, pp. 742-755 . https://doi.org/10.1038/s43587-022-00263-3
Cellular senescence is an important factor in aging and many age-related diseases, but understanding its role in health is challenging due to the lack of exclusive or universal markers. Using neural networks, we predict senescence from the nuclear mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5eda787a7c1be611f28987041f5a0c
https://curis.ku.dk/ws/files/319160606/s43587_022_00263_3.pdf
https://curis.ku.dk/ws/files/319160606/s43587_022_00263_3.pdf
Autor:
Daniel A Winer, Dina Radenkovic, Eric Verdin, Anthony J Covarrubias, Juliet M Bartleson, David Furman
Publikováno v:
Nat Aging
The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with particular risk for severe disease and death in older adults and in adults with age-related metabolic and cardiovascular disease. Recent advances in the science of ageing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c3dcfa2f766d1eeac090191564e94e
https://pubmed.ncbi.nlm.nih.gov/34746804
https://pubmed.ncbi.nlm.nih.gov/34746804
Autor:
Katsuhiko Ishihara, Christopher D. Wiley, Qiuxia Wu, Indra Heckenbach, Ryan Kwok, Herbert G. Kasler, Nathan Basisty, Judith Campisi, Eric Verdin, Jose Alberto Lopez-Dominguez, Issam Ben-Sahra, Shankar S. Iyer, Kaitlyn Vitangcol, Mark S. Schmidt, Charles Brenner, Ik Jung Kim, John C. Newman, Elena Silva, Hoi Shan Wong, Yong-Moon Lee, Abhijit Kale, Eddy Gibbs, Kyong Oh Shin, Morten Scheibye-Knudsen, Angela Oliveira Pisco, Rosalba Perrone, Anthony J. Covarrubias, Stephen R. Quake, Melanie Ott, Rebeccah Riley, Birgit Schilling
Publikováno v:
Nat Metab
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its associated diseases. However, the mechanism for this decline is unclear. Here, we show that pro-inflammatory M1-like macrophages, but not naive or M2 macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f61511ea586b3cbd91a077842b7bacd
https://europepmc.org/articles/PMC7908681/
https://europepmc.org/articles/PMC7908681/
Autor:
Ik Jung Kim, Nathan Basisty, Judith Campisi, Mark S. Schmidt, Abhijit Kale, Eddy Gibbs, Morten Scheibye-Knudsen, Katsuhiko Ishihara, Melanie Ott, John C. Newman, Qiuxia Wu, Jose Alberto Lopez-Dominguez, Elena Silva, Christopher D. Wiley, Ryan Kwok, Shankar S. Iyer, Kaitlyn Vitangcol, Stephen R. Quake, Rosalba Perrone, Anthony J. Covarrubias, Eric Verdin, Issam Ben-Sahra, Charles Brenner, Birgit Schilling, Rebeccah Riley, Hoi Shan Wong, Angela Oliveira Pisco, Indra Heckenbach, Herbert G. Kasler, Yong-Moon Lee, Kyong Oh Shin
Publikováno v:
Nature Metabolism. 3:120-121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c81277600397bd1f9fb5695cdf07b6
https://doi.org/10.1038/s42255-020-00328-w
https://doi.org/10.1038/s42255-020-00328-w
Autor:
Jose Alberto Lopez-Dominguez, Issam Ben-Sahra, Melanie Ott, Judith Campisi, Birgit Schilling, Charles Brenner, Katsuhiko Ishihara, Christopher D. Wiley, Natan Basisty, Qiuxia Wu, Mark S. Schmidt, Shankar S. Iyer, Angela Oliveira Pisco, Eric Verdin, Ryan Kwok, Stephen R. Quake, Abhijit Kale, Yong-Moon Lee, Kyong Oh Shin, Indra Heckenbach, Herbert G. Kasler, Rosalba Perrone, Anthony J. Covarrubias, John C. Newman
SummaryDecline in tissue NAD levels during aging is linked to aging and its associated diseases. However, the mechanism for aging-associated NAD decline remains unclear. Here we report that pro-inflammatory M1-like macrophages, but not naïve or M2 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c337bae919676d884fa3ffbbd7e316
Publikováno v:
Seminars in Immunology. 27:286-296
Macrophages are pleiotropic cells that assume a variety of functions depending on their tissue of residence and tissue state. They maintain homeostasis as well as coordinate responses to stresses such as infection and metabolic challenge. The ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39768dc42dd2498844cf61839ff8621
https://doi.org/10.1016/j.smim.2015.08.001
https://doi.org/10.1016/j.smim.2015.08.001
Autor:
Saptarsi M. Haldar, Che-Ping Ng, Yu Huang, Philipp Gut, Minghao Zhao, Eric Verdin, Anthony J. Covarrubias, Xinxing Yu, John C. Newman
Publikováno v:
Cell metabolism. 26(3)
Summary Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9b7085f9f8be65e4564cd55238c0e9
https://pubmed.ncbi.nlm.nih.gov/29293913
https://pubmed.ncbi.nlm.nih.gov/29293913