Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Anthony J. Cesare"'
Autor:
Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we ident
Externí odkaz:
https://doaj.org/article/a2cf012d392f4eca877ee8790143a0a5
Autor:
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised. Here, w
Externí odkaz:
https://doaj.org/article/c6f9e1aee6c04251a8ad3f7b91d37b75
Autor:
Robert Lu, Christopher B. Nelson, Samuel Rogers, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108655- (2024)
Summary: Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length. One of the defining features of ALT cells is the prevalence of extrachromosomal tel
Externí odkaz:
https://doaj.org/article/7afcb5613bf944d3bed2bcb1efe3f51e
Autor:
V. Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O’Connor, Chris D. Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David C. S. Huang, Makoto T. Hayashi, Anthony J. Cesare
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.
Externí odkaz:
https://doaj.org/article/dae63874a0924b7f84dd69ccfd135eb0
Autor:
Georgia R. Kafer, Anthony J. Cesare
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Murine development demands that pluripotent epiblast stem cells in the peri-implantation embryo increase from approximately 120 to 14,000 cells between embryonic days (E) 4.5 and E7.5. This is possible because epiblast stem cells can complete cell cy
Externí odkaz:
https://doaj.org/article/35c0a25b950f441c971e3247460d1555
Autor:
Samantha L. Ginn, Anais K. Amaya, Sophia H.Y. Liao, Erhua Zhu, Sharon C. Cunningham, Michael Lee, Claus V. Hallwirth, Grant J. Logan, Szun S. Tay, Anthony J. Cesare, Hilda A. Pickett, Markus Grompe, Kimberley Dilworth, Leszek Lisowski, Ian E. Alexander
Publikováno v:
JHEP Reports, Vol 2, Iss 1, Pp - (2020)
Background & Aims: Genome editing technology has immense therapeutic potential and is likely to rapidly supplant contemporary gene addition approaches. Key advantages include the capacity to directly repair mutant loci with resultant recovery of phys
Externí odkaz:
https://doaj.org/article/81b618aa4be6420b93bda12009cd595b
Autor:
Sunali Mehta, Cushla McKinney, Michael Algie, Chandra S. Verma, Srinivasaraghavan Kannan, Rhodri Harfoot, Tara K. Bartolec, Puja Bhatia, Alistair J. Fisher, Maree L. Gould, Kim Parker, Anthony J. Cesare, Heather E. Cunliffe, Scott B. Cohen, Torsten Kleffmann, Antony W. Braithwaite, Adele G. Woolley
Publikováno v:
Cancers, Vol 12, Iss 2, p 315 (2020)
Elevated levels of nuclear Y-box binding protein 1 (YB-1) are linked to poor prognosis in cancer. It has been proposed that entry into the nucleus requires specific proteasomal cleavage. However, evidence for cleavage is contradictory and high YB-1 l
Externí odkaz:
https://doaj.org/article/289b321ab9ba48a3bb42a86410a3e1b4
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1521-1529 (2012)
Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse confocal microscopy allowed us to evaluate the spatial distribution of telomeres within the
Externí odkaz:
https://doaj.org/article/cd076ee6d9f24865a08d5042f77f54e8
Autor:
Michelle Haber, Murray D. Norris, Katerina V. Gurova, Andrei V. Gudkov, David S. Ziegler, Anthony J. Cesare, Ricky W. Johnstone, Glenn Marshall, Jamie I. Fletcher, Michelle J. Henderson, Daniel R. Carter, Andrew J. Gifford, Alvin Kamili, Lei Zhai, Sophie Allan, Stephanie Alfred, Georgina Eden, Adam Kearns, Erin Mosmann, Jessica A. Pettitt, Frances K. Kusuma, Jennifer Brand, Hazel Quek, Pooja Venkat, Chelsea Mayoh, Aisling O'Connor, Katerina I. Leonova, Natalia Issaeva, Laura D. Gamble, Anahid Ehteda, Rachael Terry, Angelika Bongers, Emma Ronca, Mawar Karsa, Ruby Pandher, Jayne Murray, Klaartje Somers, Lin Xiao
HT10806TG_CBL0137 treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a65865b88e665572993028e81a66b25
https://doi.org/10.1158/1078-0432.22481328.v1
https://doi.org/10.1158/1078-0432.22481328.v1
Autor:
Michelle Haber, Murray D. Norris, Katerina V. Gurova, Andrei V. Gudkov, David S. Ziegler, Anthony J. Cesare, Ricky W. Johnstone, Glenn Marshall, Jamie I. Fletcher, Michelle J. Henderson, Daniel R. Carter, Andrew J. Gifford, Alvin Kamili, Lei Zhai, Sophie Allan, Stephanie Alfred, Georgina Eden, Adam Kearns, Erin Mosmann, Jessica A. Pettitt, Frances K. Kusuma, Jennifer Brand, Hazel Quek, Pooja Venkat, Chelsea Mayoh, Aisling O'Connor, Katerina I. Leonova, Natalia Issaeva, Laura D. Gamble, Anahid Ehteda, Rachael Terry, Angelika Bongers, Emma Ronca, Mawar Karsa, Ruby Pandher, Jayne Murray, Klaartje Somers, Lin Xiao
Supplementary Figure Legends S1-S16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418baa2ab5037ab880d09c89a3ddcd0f
https://doi.org/10.1158/1078-0432.22481343.v1
https://doi.org/10.1158/1078-0432.22481343.v1