Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Anthony J. Barak"'
Autor:
Kusum K. Kharbanda, Dean J. Tuma, Tamara Bernard, Anthony J. Barak, Sandeep Mukherjee, Michael F. Sorrell
Publikováno v:
The Open Translational Medicine Journal. 3:1-4
Introduction: Nonalcoholic steatohepatitis (NASH) is an important cause of cirrhosis and over the past decade has accounted for an increasing proportion of liver transplants in the United States. Unfortunately there is no treatment for NASH except fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54b5c72da3b62752fec11128e9bbd5d8
https://doi.org/10.2174/1876399501103010001
https://doi.org/10.2174/1876399501103010001
Autor:
David D. Rogers, Gerri L. Siford, Mark E Mailliard, Dean J. Tuma, Anthony J. Barak, Kusum K. Kharbanda, Harriet C. Beckenhauer, Michael F. Sorrell
Publikováno v:
The Journal of Nutrition. 135:519-524
Previous studies showed that chronic ethanol administration alters methionine metabolism in the liver, resulting in increased intracellular S-adenosylhomocysteine (SAH) levels and increased homocysteine release into the plasma. We showed further that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b75df6c6b72dc5bdea2c81ed82c09c1
https://doi.org/10.1093/jn/135.3.519
https://doi.org/10.1093/jn/135.3.519
Autor:
Harriet C. Beckenhauer, Mark E. Mailliard, Kusum K. Kharbanda, Anthony J. Barak, Dean J. Tuma
Publikováno v:
The Journal of Nutrition. 133:2845-2848
Previous studies showed that chronic ethanol administration inhibits methionine synthase activity, resulting in impaired homocysteine remethylation to form methionine. This defect in homocysteine remethylation was shown to increase plasma homocystein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fca386af6e4ce5d600b8992d62c453
https://doi.org/10.1093/jn/133.9.2845
https://doi.org/10.1093/jn/133.9.2845
Publikováno v:
Alcohol. 26:65-67
Among the most important pathways for liver integrity in the body are the two that synthesize methionine and S-adenosylmethionine (SAM) through methylation of homocysteine. Results of studies in this laboratory have demonstrated ethanolic inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a9c7f9e1b104900f0db5dfd35f74ca2
https://doi.org/10.1016/s0741-8329(01)00201-4
https://doi.org/10.1016/s0741-8329(01)00201-4
Publikováno v:
Alcoholism: Clinical and Experimental Research. 21:1100-1102
The feeding of ethanol to experimental animals results in fatty infiltration of the liver. Recent findings have shown that ethanol-induced steatosis is accompanied by a lowering in hepatic S-adenosylmethionine (SAM) levels. It is known that SAM provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::566618ed13236cfab27d48f75116529a
https://doi.org/10.1111/j.1530-0277.1997.tb04259.x
https://doi.org/10.1111/j.1530-0277.1997.tb04259.x
Autor:
David D. Rogers, Gerri L. Siford, Kusum K. Kharbanda, Harriet C. Beckenhauer, Mark E. Mailliard, Dean J. Tuma, Michael F. Sorrell, Anthony J. Barak
Publikováno v:
Biochemical pharmacology. 70(12)
Previous studies from our laboratory have shown that ethanol consumption results in an increase in hepatocellular S-adenosylhomocysteine levels. Because S-adenosylhomocysteine is a potent inhibitor of methylation reactions, we propose that increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2c326af93e609e70a0aa89af71a8fc
https://pubmed.ncbi.nlm.nih.gov/16253211
https://pubmed.ncbi.nlm.nih.gov/16253211
Autor:
Anthony J. Barak, Kusum K. Kharbanda
Publikováno v:
Comprehensive Handbook of Alcohol Related Pathology
This chapter reviews the negative effects of ethanol in multiple steps in methionine metabolism that may lead to liver injury. Alcoholic liver disease is a major health care problem and ethanol consumption is reported to predominantly inhibit the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c37800e892e93aa7524fdc1c6126094d
https://doi.org/10.1016/b978-012564370-2/50059-3
https://doi.org/10.1016/b978-012564370-2/50059-3
Publikováno v:
Alcohol. 11:501-503
Earlier studies by other investigators have shown that S-adenosylmethinione (SAM) has the capacity to attenuate liver injury in experimental animals. In a recent study in this laboratory, it was shown that when supplemental dietary betaine was given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d3a8ed1b13756275b652568437df01
https://doi.org/10.1016/0741-8329(94)90075-2
https://doi.org/10.1016/0741-8329(94)90075-2
Publikováno v:
Alcohol (Fayetteville, N.Y.). 26(2)
Among the most important pathways for liver integrity in the body are the two that synthesize methionine and S-adenosylmethionine (SAM) through methylation of homocysteine. Results of studies in this laboratory have demonstrated ethanolic inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49673373e85550c240afedbc9f920a2f
https://pubmed.ncbi.nlm.nih.gov/12007580
https://pubmed.ncbi.nlm.nih.gov/12007580
Publikováno v:
Alcohol (Fayetteville, N.Y.). 25(2)
Results of previous studies have shown that chronic ethanol administration impairs methionine synthetase activity and decreases S-adenosylmethionine levels in the liver, indicating interference with homocysteine remethylation. The purpose of the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd355337cfff1d772728c7bc5eeb2420
https://pubmed.ncbi.nlm.nih.gov/11747976
https://pubmed.ncbi.nlm.nih.gov/11747976