Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anthony J Schulien"'
Autor:
Kevin K Ogden, Wenjuan Chen, Sharon A Swanger, Miranda J McDaniel, Linlin Z Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J Kosobucki, Anthony J Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E Cohen, Elias Aizenman, Stephen F Traynelis, Hongjie Yuan
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006536 (2017)
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein
Externí odkaz:
https://doaj.org/article/60f8bb0309e04853b4d0c688c30b36ad
Autor:
Anthony J. Schulien, Paul A. Gardner, Barton F. Branstetter, Carl H. Synderman, Georgios A. Zenonos, Michael M. McDowell, Eric W. Wang
Publikováno v:
Special Virtual Symposium of the North American Skull Base Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851bc117995525182411d7d90d0b0be6
https://doi.org/10.1055/s-0041-1725467
https://doi.org/10.1055/s-0041-1725467
Autor:
Eric W. Wang, Nitin Agarwal, Hanna Algattas, Anthony J. Schulien, Hussam Abou-Al-Shaar, Paul A. Gardner, Nima Alan, Daryl Fields, Carl H. Snyderman, Georgios A. Zenonos, Michael M. McDowell
Publikováno v:
Special Virtual Symposium of the North American Skull Base Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500fe22f59f38dee70f9f90aa47cb557
https://doi.org/10.1055/s-0041-1725277
https://doi.org/10.1055/s-0041-1725277
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6107, p 6107 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Achieving neuroprotection in ischemic stroke patients has been a multi-decade medical challenge. Numerous clinical trials were discontinued in futility and many were terminated in response to deleterious treatment effects. Recently however, several p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5645d8437833d6efae8220daa423295c
https://pubmed.ncbi.nlm.nih.gov/32854248
https://pubmed.ncbi.nlm.nih.gov/32854248
Autor:
Karen A. Hartnett, Kai He, Jason A. Justice, Elias Aizenman, Anthony J. Schulien, Niyathi H. Shah
Publikováno v:
Neuroscience. 354:158-167
As the predominant mediator of the delayed rectifier current, KV2.1 is an important regulator of neuronal excitability. KV2.1, however, also plays a well-established role in apoptotic cell death. Apoptogenic stimuli induce syntaxin-dependent traffick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97b944c52006bcd4ec09d102d7dc9f09
https://doi.org/10.1016/j.neuroscience.2017.04.034
https://doi.org/10.1016/j.neuroscience.2017.04.034
Autor:
Subhrajit Bhattacharya, Varun Kannan, Hirofumi Kusumoto, Yuehua Zhang, Gabrielle J. Kosobucki, An-Sofie Schoonjans, Annapurna Poduri, Sylvie Nguyen, Xinhua Bao, Elias Aizenman, Elisabeth Schuler, Dragan Marjanovic, Hongjie Yuan, Scott J. Myers, Christelle Moufawad El Achkar, Christina Fenger, Nina Dirkx, Gaetan Lesca, Yuwu Jiang, Stephen F. Traynelis, Jean-Marie Cuisset, Ye Wu, Wenshu XiangWei, Steffen Syrbe, Katherine L. Helbig, Anthony J. Schulien, Johannes R. Lemke, Yuchen Xu
Publikováno v:
Brain
N-methyl D-aspartate receptors are ligand-gated ionotropic receptors mediating a slow, calcium-permeable component of excitatory synaptic transmission in the CNS. Variants in genes encoding NMDAR subunits have been associated with a spectrum of neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4160e0d5c019871f4b8fb7caebbcbf36
https://hdl.handle.net/10067/1657750151162165141
https://hdl.handle.net/10067/1657750151162165141
Autor:
Gabrielle J. Kosobucki, Rosetta M. Chiavacci, Celina von Stülpnagel-Steinbeis, Lifeng Tian, Wenjuan Chen, Konstanze Hörtnagel, Eric D. Marsh, Xilma R. Ortiz-Gonzalez, Ulrike B. S. Hedrich, Stephen F. Traynelis, Claudia Naase, Anel Tankovic, Marni J. Falk, Hakon Hakonarson, Johannes R. Lemke, Dong Li, Hirofumi Kusumoto, Gina E. Elsen, Elias Aizenman, Chun Hu, Anthony J. Schulien, Hongjie Yuan, Elizabeth M. McCormick, Frieder Brueckner
Publikováno v:
The American Journal of Human Genetics. 99:802-816
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated cation channels that mediate excitatory synaptic transmission. Genetic mutations in multiple NMDAR subunits cause various childhood epilepsy syndromes. Here, we report a de novo recurrent heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31548c3163bcbcfe74f0546ba351c4d5
https://doi.org/10.1016/j.ajhg.2016.07.013
https://doi.org/10.1016/j.ajhg.2016.07.013
Autor:
Roberto Di Maio, Elias Aizenman, Zachary P. Wills, Jason A. Justice, Anthony J. Schulien, Niyathi H. Shah
Publikováno v:
The Journal of Physiology. 594:2647-2659
Key points Increases in intracellular Zn(2+) concentrations are an early, necessary signal for the modulation of Kv2.1 K(+) channel localization and physiological function. Intracellular Zn(2+) -mediated Kv2.1 channel modulation is dependent on calci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd16a271110ea17113b01b3d6218722
https://doi.org/10.1113/jp272117
https://doi.org/10.1113/jp272117
Autor:
Shalom Mammen, Gabrielle J. Kosobucki, Chung-Yang Yeh, Elias Aizenman, Michael J. Palladino, Daniel T. Manjooran, Anthony J. Schulien, Jason A. Justice, Karen A. Hartnett-Scott
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(2)
We present the design of an innovative molecular neuroprotective strategy and provide proof-of-concept for its implementation, relying on the injury-mediated activation of an ectopic gene construct. As oxidative injury leads to the intracellular libe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148c3d32cac69ff95f61adcd81e561d8
https://pubmed.ncbi.nlm.nih.gov/30190339
https://pubmed.ncbi.nlm.nih.gov/30190339
Autor:
Niyathi H. Shah, Katerina Clemens, Talia D. Aizenman, Anthony J. Schulien, Elias Aizenman, Zachary P. Wills, Thomas M. Hageman
Publikováno v:
The Journal of Neuroscience. 34:4326-4331
Kv2.1 is a major delayed rectifying K+channel normally localized to highly phosphorylated somatodendritic clusters in neurons. Excitatory stimuli induce calcineurin-dependent dephosphorylation and dispersal of Kv2.1 clusters, with a concomitant hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1764006b2e0db3111239628c9a37d92d
https://doi.org/10.1523/jneurosci.5184-13.2014
https://doi.org/10.1523/jneurosci.5184-13.2014