Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Anthony J Clarke"'
Autor:
David Sychantha, Carys S Jones, Dustin J Little, Patrick J Moynihan, Howard Robinson, Nicola F Galley, David I Roper, Christopher G Dowson, P Lynne Howell, Anthony J Clarke
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006667 (2017)
The O-acetylation of the essential cell wall polymer peptidoglycan occurs in most Gram-positive bacterial pathogens, including species of Staphylococcus, Streptococcus and Enterococcus. This modification to peptidoglycan protects these pathogens from
Externí odkaz:
https://doaj.org/article/69d931129d424af5a59c1b0e4655dc8a
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006558 (2017)
The serine-rich repeat (SRR) glycoproteins are a family of adhesins found in many Gram-positive bacteria. Expression of the SRR adhesins has been linked to virulence for a variety of infections, including streptococcal endocarditis. The SRR preprotei
Externí odkaz:
https://doaj.org/article/10b1218939bb49d08a894c41eb7ff5b1
Autor:
Perrin Baker, Tyler Ricer, Patrick J Moynihan, Elena N Kitova, Marthe T C Walvoort, Dustin J Little, John C Whitney, Karen Dawson, Joel T Weadge, Howard Robinson, Dennis E Ohman, Jeroen D C Codée, John S Klassen, Anthony J Clarke, P Lynne Howell
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004334 (2014)
The O-acetylation of polysaccharides is a common modification used by pathogenic organisms to protect against external forces. Pseudomonas aeruginosa secretes the anionic, O-acetylated exopolysaccharide alginate during chronic infection in the lungs
Externí odkaz:
https://doaj.org/article/e34e3f18f1c64d8d892971bdb09e1da6
Autor:
Jennifer M. Colquhoun, Marjan Farokhyfar, Alexander C. Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT The ADC (AmpC) β-lactamase is universally present in the Acinetobacter baumannii chromosome, suggesting it may have a yet-to-be-identified cellular function. Using peptidoglycan composition analysis, we show that overexpressing the ADC-7 β
Externí odkaz:
https://doaj.org/article/c09b7aa4fb2e419cbd3bbd5b7112233e
Autor:
Erin M. Anderson, Neethu Shaji Saji, Alexander C. Anderson, Dyanne Brewer, Anthony J. Clarke, Cezar M. Khursigara
Publikováno v:
mSystems, Vol 7, Iss 3 (2022)
ABSTRACT Epidemic strains of Pseudomonas aeruginosa are highly virulent opportunistic pathogens with increased transmissibility and enhanced antimicrobial resistance. Understanding the cellular mechanisms behind this heightened virulence and resistan
Externí odkaz:
https://doaj.org/article/22a4554b002542b5936eaefba2f65226
Autor:
Jennifer M. Colquhoun, Marjan Farokhyfar, Anna R. Hutcheson, Alexander Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT β-Lactamase expression is the major mechanism of resistance to penicillins, cephalosporins, and carbapenems in the multidrug-resistant (MDR) bacterium Acinetobacter baumannii. In fact, stable high-level expression of at least one β-lactama
Externí odkaz:
https://doaj.org/article/480fdfe5fbe64cbcafe5beec72f3166d
Publikováno v:
Glycobiology.
The substitution and de-substitution of carbohydrate materials are important steps in the biosynthesis and/or breakdown of a wide variety of biologically important polymers. The SGNH hydrolase superfamily is a group of related and well-studied protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c104b2041befa936b2a0d1bc8d20473d
https://doi.org/10.1093/glycob/cwac045
https://doi.org/10.1093/glycob/cwac045
Publikováno v:
Antibiotics, Vol 8, Iss 2, p 65 (2019)
The O-acetylation of peptidoglycan occurs in many Gram-negative and most Gram-positive pathogens and this modification to the essential wall polymer controls the lytic activity of the autolysins, particularly the lytic transglycosylases, and inhibits
Externí odkaz:
https://doaj.org/article/cd2777469d8748c8b39d6aa8d92f5fff
Autor:
David A. Crisante, Danielle L. Sexton, Anthony J. Clarke, Evan M F Shepherdson, Francesca A. Herlihey, Ashley S. Brott, Marie A. Elliot
Publikováno v:
J Biol Chem
Bacterial dormancy can take many forms, including formation of Bacillus endospores, Streptomyces exospores, and metabolically latent Mycobacterium cells. In the actinobacteria, including the streptomycetes and mycobacteria, the rapid resuscitation fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5ef6eb739f82f4f3d409e887072b91
https://doi.org/10.1074/jbc.ra120.013994
https://doi.org/10.1074/jbc.ra120.013994
Publikováno v:
Proceedings of the National Academy of Sciences. 118
The O-acetylation of exopolysaccharides, including the essential bacterial cell wall polymer peptidoglycan, confers resistance to their lysis by exogenous hydrolases. Like the enzymes catalyzing the O-acetylation of exopolysaccharides in the Golgi of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d7691ef9c286477c6b5a3075c02d92
https://doi.org/10.1073/pnas.2103602118
https://doi.org/10.1073/pnas.2103602118