Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Anthony J Berdis"'
Autor:
Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J Robinson, William P Schiemann, Anthony J Berdis, Emmanuel Skordalakes, Derek J Taylor
Publikováno v:
PLoS Biology, Vol 17, Iss 4, p e3000204 (2019)
Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-tr
Externí odkaz:
https://doaj.org/article/89d34eb64c654bd6875333e2810f44f3
Autor:
Michelle K Scotland, Justin M H Heltzel, James E Kath, Jung-Suk Choi, Anthony J Berdis, Joseph J Loparo, Mark D Sutton
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005507 (2015)
Translesion DNA synthesis (TLS) by specialized DNA polymerases (Pols) is a conserved mechanism for tolerating replication blocking DNA lesions. The actions of TLS Pols are managed in part by ring-shaped sliding clamp proteins. In addition to catalyzi
Externí odkaz:
https://doaj.org/article/a93f1e5911504317a3253dcdaa0248cf
Autor:
Laurie H Sanders, Babho Devadoss, Geraldine V Raja, Jaime O'Connor, Shengchang Su, Daniel J Wozniak, Daniel J Hassett, Anthony J Berdis, Mark D Sutton
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18824 (2011)
Pseudomonas aeruginosa is especially adept at colonizing the airways of individuals afflicted with the autosomal recessive disease cystic fibrosis (CF). CF patients suffer from chronic airway inflammation, which contributes to lung deterioration. Onc
Externí odkaz:
https://doaj.org/article/bab0790e3e604070b82fe25ffb802cbe
Autor:
Jung-Suk Choi, Anthony J. Berdis
Publikováno v:
European Journal of Haematology. 104:97-109
OBJECTIVES Doxorubicin is a DNA-damaging agent used to treat hematological cancers. Unfortunately, drug resistance can occur by defective DNA repair activity coupled with the ability of DNA polymerases to misreplicate unrepaired DNA lesions. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29ebb45b0443c5c4f9c7b1cc9707040
https://doi.org/10.1111/ejh.13347
https://doi.org/10.1111/ejh.13347
Autor:
Tawna L Whited, Derek J. Taylor, Anthony J. Berdis, Mengyuan Xu, Xuehuo Zeng, Junran Zhang, Wilnelly Hernandez-Sanchez, Diane Baus
Publikováno v:
Cell Reports. 23:3031-3041
Summary Telomerase, the end-replication enzyme, is reactivated in malignant cancers to drive cellular immortality. While this distinction makes telomerase an attractive target for anti-cancer therapies, most approaches for inhibiting its activity hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f5b475707e8327293c52b44cca3a72
https://doi.org/10.1016/j.celrep.2018.05.020
https://doi.org/10.1016/j.celrep.2018.05.020
Publikováno v:
Cancer Research. 78:1083-1096
Temozolomide is a DNA-alkylating agent used to treat brain tumors, but resistance to this drug is common. In this study, we provide evidence that efficacious responses to this drug can be heightened significantly by coadministration of an artificial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9671ccd79ff7376308be27957b6c711a
https://doi.org/10.1158/0008-5472.can-17-2464
https://doi.org/10.1158/0008-5472.can-17-2464
Autor:
Anthony J. Berdis
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 1707, p 1707 (2021)
Biomolecules, Vol 11, Iss 1707, p 1707 (2021)
The central dogma of molecular biology proposes that in a typical cell, the flow of genetic information proceeds from DNA to RNA to polypeptide [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f4a117123321ccb0211c2eea14c45c
https://doi.org/10.3390/biom11111707
https://doi.org/10.3390/biom11111707
Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents
Publikováno v:
Oncotarget
// Jung-Suk Choi 1 , Seol Kim 2 , Edward Motea 3 and Anthony Berdis 1, 2, 4, 5 1 Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA 2 Department of Biological, Geological, and Environmental Sciences, Cleveland State Univers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d9dc0684ca681b2dbd07c01df678d4
https://doi.org/10.18632/oncotarget.17254
https://doi.org/10.18632/oncotarget.17254
Autor:
Jung-Suk Choi, Anthony J. Berdis
Publikováno v:
Methods in Molecular Biology ISBN: 9781493992157
The misreplication of damaged DNA, a biological process termed translesion DNA synthesis (TLS), produces a large number of adverse effects on human health. This chapter describes the application of an artificial nucleoside/nucleotide system that func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f62abf2657b5dfe27d842c1a4023531
https://doi.org/10.1007/978-1-4939-9216-4_15
https://doi.org/10.1007/978-1-4939-9216-4_15
Autor:
Anthony J. Berdis, Irene Lee
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1864:65-69
Historically, the study of proteins has relied heavily on characterizing the activity of a single purified protein isolated from other cellular components. This classic approach allowed scientists to unambiguously define the intrinsic kinetic and che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8c541af53ff866cf3eacc54083bd56
https://doi.org/10.1016/j.bbapap.2015.07.011
https://doi.org/10.1016/j.bbapap.2015.07.011