Effect of maternal steroid on developing diaphragm integrity.

Autor: Yong Song, Denise L Demmer, Gavin J Pinniger, Tina Lavin, Mia V MacMillan, Jane J Pillow, Anthony J Bakker

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e93224 (2014)

Antenatal steroids reduce the severity of initial respiratory distress of premature newborn babies but may have an adverse impact on other body organs. The study aimed to examine the effect of maternal steroids on postnatal respiratory muscle functio

Externí odkaz: https://doaj.org/article/01468b33e7e94645bed3d639d6aa7072

Actin nemaline myopathy mouse reproduces disease, suggests other actin disease phenotypes and provides cautionary note on muscle transgene expression.

Autor: Gianina Ravenscroft, Connie Jackaman, Caroline A Sewry, Elyshia McNamara, Sarah E Squire, Allyson C Potter, John Papadimitriou, Lisa M Griffiths, Anthony J Bakker, Kay E Davies, Nigel G Laing, Kristen J Nowak

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28699 (2011)

Mutations in the skeletal muscle α-actin gene (ACTA1) cause congenital myopathies including nemaline myopathy, actin aggregate myopathy and rod-core disease. The majority of patients with ACTA1 mutations have severe hypotonia and do not survive beyo

Externí odkaz: https://doaj.org/article/8753ec1ece004cf593775b53dd3a6757

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Autor: Michael W. Lawlor, Hayley Goullee, Rachel Harries, Coen A.C. Ottenheijm, Anthony J. Bakker, Julien Ochala, Robbert van der Pijl, Lisa M. Griffiths, Katarina Pelin, Gianina Ravenscroft, Kristen J. Nowak, Carina Wallgren-Pettersson, Elyshia McNamara, Caroline Sewry, Catherine D. Wingate, Rhonda L. Taylor, Joshua S. Clayton, Jacob A. Ross, Nigel G. Laing, J. Laitila

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Laitila, J M, McNamara, E L, Wingate, C D, Goullee, H, Ross, J A, Taylor, R L, van der Pijl, R, Griffiths, L M, Harries, R, Ravenscroft, G, Clayton, J S, Sewry, C, Lawlor, M W, Ottenheijm, C A C, Bakker, A J, Ochala, J, Laing, N G, Wallgren-Pettersson, C, Pelin, K & Nowak, K J 2020, ' Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb ', Acta neuropathologica communications, vol. 8, no. 1, 18 . https://doi.org/10.1186/s40478-020-0893-1
Acta neuropathologica communications, 8(1):18. BioMed Central

Nemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant disease burden. Most NEB-NM patients have autosomal recessive disease due to a compound hete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3f5c6a3537aab06d478ab85db00ac2
https://pubmed.ncbi.nlm.nih.gov/32066503

Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle

Autor: Catherine D. Wingate, Christopher John Barclay, Bradley S. Launikonis, Tanya R. Cully, Anthony J. Bakker

Publikováno v: Journal of General Physiology. 149:323-334

Fast-twitch skeletal muscle fibers are often exposed to motor neuron double discharges (≥200 Hz), which markedly increase both the rate of contraction and the magnitude of the resulting force responses. However, the mechanism responsible for these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9e3a33b1f228116e2ff860d2aea9912
https://doi.org/10.1085/jgp.201611727

Hierarchical Patterning of Multifunctional Conducting Polymer Nanoparticles as a Bionic Platform for Topographic Contact Guidance

Autor: Stuart I. Hodgetts, Alaa M. Munshi, Igor Luzinov, Giles W. Plant, Jianli Zou, Alan R. Harvey, K. Swaminathan Iyer, Dominic Ho, Anthony J. Bakker, Vipul Agarwal, Nicole M. Smith, Xianjue Chen

Publikováno v: ACS Nano. 9:1767-1774

The use of programmed electrical signals to influence biological events has been a widely accepted clinical methodology for neurostimulation. An optimal biocompatible platform for neural activation efficiently transfers electrical signals across the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6490cf8abc8b8737f2c67d4072da33ac
https://doi.org/10.1021/nn506607x