Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anthony J, Hinrich"'
Autor:
Ria Thomas, Kyle J. Connolly, Oeystein R. Brekk, Anthony J. Hinrich, Michelle L. Hastings, Ole Isacson, Penelope J. Hallett
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Inflammatory processes and mechanisms are of central importance in neurodegenerative diseases. In the brain, α-synucleinopathies such as Parkinson’s disease (PD) and Lewy body dementia (LBD) show immune cytokine network activation and inc
Externí odkaz:
https://doaj.org/article/19fde4928a4f45e5b0fc284e1cba2d1f
Autor:
Joanna A. Korecka, Ria Thomas, Anthony J. Hinrich, Alyssa M. Moskites, Zach K. Macbain, Penelope J. Hallett, Ole Isacson, Michelle L. Hastings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 623-635 (2020)
Parkinson’s disease (PD) is a progressive neurological disorder estimated to affect 7–10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity h
Externí odkaz:
https://doaj.org/article/c35d1d9940544cb3b606f79c91e2929b
Autor:
Joanna A. Korecka, Sebastien Talbot, Teresia M. Osborn, Sherida M. de Leeuw, Simon A. Levy, Eliza J. Ferrari, Alyssa Moskites, Elise Atkinson, Francine M. Jodelka, Anthony J. Hinrich, Michelle L. Hastings, Clifford J. Woolf, Penelope J. Hallett, Ole Isacson
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 29-41 (2019)
Summary: The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S m
Externí odkaz:
https://doaj.org/article/872a0bc4898b44ba96fb040e2470c7bb
Autor:
Anthony J Hinrich, Francine M Jodelka, Jennifer L Chang, Daniella Brutman, Angela M Bruno, Clark A Briggs, Bryan D James, Grace E Stutzmann, David A Bennett, Steven A Miller, Frank Rigo, Robert A Marr, Michelle L Hastings
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 4, Pp 328-345 (2016)
Abstract Apolipoprotein E receptor 2 (ApoER2) is an apolipoprotein E receptor involved in long‐term potentiation, learning, and memory. Given its role in cognition and its association with the Alzheimer's disease (AD) risk gene, apoE, ApoER2 has be
Externí odkaz:
https://doaj.org/article/53d79b4ef2ba4429a49c1630f225c643
Autor:
Michelle L. Hastings, Zach K. Macbain, Joanna A. Korecka, Ole Isacson, Anthony J. Hinrich, Ria Thomas, Penelope J. Hallett, Alyssa Moskites
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 623-635 (2020)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Parkinson’s disease (PD) is a progressive neurological disorder estimated to affect 7–10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c39e45bdba202c50ea65c69da2ade7
https://doi.org/10.1016/j.omtn.2020.06.027
https://doi.org/10.1016/j.omtn.2020.06.027
Autor:
Jessica L. Centa, Frank Rigo, Francine M. Jodelka, Anthony J. Hinrich, Joseph Ochaba, Dominik M. Duelli, Michaela Jackson, Tyler B. Johnson, Jill M. Weimer, Michelle L. Hastings
Publikováno v:
Nat Med
CLN3 Batten disease is an autosomal recessive, neurodegenerative, lysosomal storage disease caused by mutations in CLN3, which encodes a lysosomal membrane protein(1–3). There are no disease-modifying treatments for this disease that affects up to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691da9b29531e7c892f5b7b4a35daddf
https://doi.org/10.1038/s41591-020-0986-1
https://doi.org/10.1038/s41591-020-0986-1
Autor:
Stephanie A. Carmack, Janaina C. M. Vendruscolo, M. Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D. Bosse, Daniele Mercatelli, Federico M. Giorgi, Yu Fu, Anthony J. Hinrich, Francine M. Jodelka, Karen Ling, Robert O. Messing, Randall T. Peterson, Frank Rigo, Scott Edwards, Pietro P. Sanna, Marisela Morales, Michelle L. Hastings, George F. Koob, Leandro F. Vendruscolo
Publikováno v:
Molecular psychiatry. 27(5)
The global crisis of opioid overdose fatalities has led to an urgent search to discover the neurobiological mechanisms of opioid use disorder (OUD). A driving force for OUD is the dysphoric and emotionally painful state (hyperkatifeia) that is produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fefad6c9723346ce90142d40373ffa8
https://pubmed.ncbi.nlm.nih.gov/35296810
https://pubmed.ncbi.nlm.nih.gov/35296810
Autor:
Ole Isacson, Anthony J. Hinrich, Simon A. Levy, Elise Atkinson, Sherida M. de Leeuw, Eliza J. Ferrari, Alyssa Moskites, Sébastien Talbot, Clifford J. Woolf, Penelope J. Hallett, Teresia Osborn, Joanna A. Korecka, Francine M. Jodelka, Michelle L. Hastings
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 29-41 (2019)
Summary: The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f993e77d09a81f7c9f359c3ea4c53bf5
http://www.sciencedirect.com/science/article/pii/S2213671118304909
http://www.sciencedirect.com/science/article/pii/S2213671118304909
Autor:
Eric Norstrom, Jennifer L. Chang, Robert A. Marr, Frank Rigo, Brandon Roman, Michelle L. Hastings, Anthony J. Hinrich, Michaela Norrbom
Publikováno v:
Molecular Therapy. 26:1539-1551
Alterations in amyloid beta precursor protein (APP) have been implicated in cognitive decline in Alzheimer's disease (AD), which is accelerated in Down syndrome/Trisomy 21 (DS/TS21), likely due to the extra copy of the APP gene, located on chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23629f184aa08e649d3cc68939f2629
https://doi.org/10.1016/j.ymthe.2018.02.029
https://doi.org/10.1016/j.ymthe.2018.02.029
Autor:
Daniella Brutman, Robert A. Marr, Jennifer L. Chang, Grace E. Stutzmann, Anthony J. Hinrich, Francine M. Jodelka, Michelle L. Hastings, Steven A. Miller, Angela M. Bruno, Clark A. Briggs, Bryan D. James, Frank Rigo, David A. Bennett
Publikováno v:
EMBO Molecular Medicine. 8:328-345
Apolipoprotein E receptor 2 ( ApoER2 ) is an apolipoprotein E receptor involved in long‐term potentiation, learning, and memory. Given its role in cognition and its association with the Alzheimer9s disease (AD) risk gene, apoE, ApoER2 has been prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::283d19d81711ad66882f76953ac80777
https://doi.org/10.15252/emmm.201505846
https://doi.org/10.15252/emmm.201505846