Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Anthony J, Hickey"'
Autor:
Karthik Tiruthani, Carlos Cruz‐Teran, Jasper F. W. Chan, Alice Ma, Morgan McSweeney, Whitney Wolf, Shoufeng Yuan, Vincent K. M. Poon, Chris C. S. Chan, Lakshmi Botta, Brian Farrer, Ian Stewart, Alison Schaefer, Jasmine Edelstein, Priya Kumar, Harendra Arora, Jeff T. Hutchins, Anthony J. Hickey, Kwok‐Yung Yuen, Samuel K. Lai
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Soluble angiotensin‐converting enzyme 2 (ACE2) can act as a decoy molecule that neutralizes severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by blocking spike (S) proteins on virions from binding ACE2 on host cells. Based o
Externí odkaz:
https://doaj.org/article/0194f8a6b25b4295b585d8f6aa9503ad
Publikováno v:
ACS Omega, Vol 9, Iss 10, Pp 11870-11882 (2024)
Externí odkaz:
https://doaj.org/article/f3c6859e6bc74430b547d98abc8ab94e
Autor:
Morgan D. McSweeney, Sarhad Alnajjar, Alison M. Schaefer, Zach Richardson, Whitney Wolf, Ian Stewart, Pun Sriboonyapirat, Justin McCallen, Ellen Farmer, Bernadette Nzati, Sam Lord, Brian Farrer, Thomas R. Moench, Priya A. Kumar, Harendra Arora, Raymond J. Pickles, Anthony J. Hickey, Mark Ackermann, Samuel K. Lai
Publikováno v:
Advanced Science, Vol 11, Iss 12, Pp n/a-n/a (2024)
Abstract Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants, the immunocompromised, and the elderly. RSV infects the airway epithelium via the apical membrane and almost exclusively sheds progeny virions back into
Externí odkaz:
https://doaj.org/article/dd59ff7c17a548cfb3d8d12cd68b18c5
Publikováno v:
KONA Powder and Particle Journal, Vol 40, Iss 0, Pp 172-185 (2022)
It is well established that the critical performance metrics for aerosol products are aerodynamic particle size distribution (APSD) and delivered dose uniformity (DDU). In broad terms, these performance characteristics dictate the efficiency and repr
Externí odkaz:
https://doaj.org/article/10374b1d6158438caec694a8fff56e37
Autor:
Lucila Garcia-Contreras, Shumaila Nida Muhammad Hanif, Mariam Ibrahim, Phillip Durham, Anthony J. Hickey
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2758 (2023)
CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant tuberculosis (TB). The present study was undertaken to determine the best dose and dosing regimen of inhalable CPZEN-45 powders to use in efficacy studies with TB-
Externí odkaz:
https://doaj.org/article/c4cff2cd0a714de89801d9b318e6489f
Autor:
Morgan D. McSweeney, Ian Stewart, Zach Richardson, Hyunah Kang, Yoona Park, Cheolmin Kim, Karthik Tiruthani, Whitney Wolf, Alison Schaefer, Priya Kumar, Harendra Aurora, Jeff Hutchins, Jong Moon Cho, Anthony J. Hickey, Soo Young Lee, Samuel K. Lai
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract The respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID‐19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral do
Externí odkaz:
https://doaj.org/article/690a48d647804603ba7fe97d886a266d
Autor:
Carolin Elizabeth George, Gerhard Scheuch, Ulf Seifart, Leeberk Raja Inbaraj, Sindhulina Chandrasingh, Indu K. Nair, Anthony J. Hickey, Michael R. Barer, Eve Fletcher, Rachel D. Field, Jonathan Salzman, Nathan Moelis, Dennis Ausiello, David A. Edwards
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Dehydration of the upper airways increases risks of respiratory diseases from COVID-19 to asthma and COPD. We find in human volunteer studies involving 464 human subjects in Germany, the US, and India that respiratory droplet generation incr
Externí odkaz:
https://doaj.org/article/802c9b0e713244f68372c4a18bf7e0ed
Autor:
Keyur R. Parmar, Pradeep B. Lukka, Santosh Wagh, Zaid H. Temrikar, Jiuyu Liu, Richard E. Lee, Miriam Braunstein, Anthony J. Hickey, Gregory T. Robertson, Mercedes Gonzalez-Juarrero, Andrea Edginton, Bernd Meibohm
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1759 (2023)
Spectinamides 1599 and 1810 are lead spectinamide compounds currently under preclinical development to treat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. These compounds have previously been tested at various combinati
Externí odkaz:
https://doaj.org/article/e146c5c3fef646658561f95712d507a4
Autor:
Sara E. Maloney, Ian E. Stewart, Brendan K. Podell, Hadley E. Gary, Jeffrey B. Mecham, Bryan J. Berube, Susan L. Baldwin, Rhea N. Coler, Anthony J. Hickey
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 729 (2023)
Mycobacterium tuberculosis (M.tb) has infected one-quarter of the world’s population and led to the deaths of 1.6 million individuals in 2021 according to estimates from the World Health Organization. The rise in prevalence of multidrug-resistant a
Externí odkaz:
https://doaj.org/article/fb1e73021b01468fbe479f08053d7b07
Autor:
Patrick O. Hanafin, Brian Jermain, Anthony J. Hickey, Alexander V. Kabanov, Angela DM. Kashuba, Timothy P. Sheahan, Gauri G. Rao
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 89-99 (2021)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) outbreak initiated the global coronavirus disease 2019 (COVID‐19) pandemic resulting in 42.9 million confirmed infections and > 1.1 million deaths worldwide as of October
Externí odkaz:
https://doaj.org/article/bda925b05d3b4d6ab7b8cfb0cdce9b1b