Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Anthony I Magee"'
Autor:
A. Preiss
Publikováno v:
Cell Biology International. 17:359-360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d41450c7c619a95030af189ef403f316
https://doi.org/10.1006/cbir.1993.1073
https://doi.org/10.1006/cbir.1993.1073
Autor:
Thomas Lanyon-Hogg, Naoko Masumoto, George Bodakh, Antonio D. Konitsiotis, Emmanuelle Thinon, Ursula R. Rodgers, Raymond J. Owens, Anthony I. Magee, Edward W. Tate
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 257-281 (2016)
In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final com
Externí odkaz:
https://doaj.org/article/4bfe980dcf9a43e8805f3661c29e6981
Autor:
Malgorzata Broncel, Remigiusz A Serwa, Paulina Ciepla, Eberhard Krause, Margaret J. Dallman, Anthony I. Magee, Edward W. Tate
Publikováno v:
Data in Brief, Vol 4, Iss C, Pp 379-383 (2015)
Human cells (HEK 293, HeLa, MCF-7) and zebrafish embryos were metabolically tagged with an alkynyl myristic acid probe, lysed with an SDS buffer and tagged proteomes ligated to multifunctional capture reagents via copper-catalyzed alkyne azide cycloa
Externí odkaz:
https://doaj.org/article/b46e0e25d4cc47ae80460e01c7a10398
Autor:
Milon Mondal, Balazs Pogranyi, Matthew J. Fuchter, Leran Zhang, Christian Siebold, Jake L. Greenfield, Lea Sefer, Sebastian A. Andrei, Thomas Lanyon-Hogg, Markus Ritzefeld, Callum D. Johnston, Joshua Newington, Claire E. Coupland, Anthony I. Magee, Edward W. Tate
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
The mammalian membrane‐bound O‐acyltransferase (MBOAT) superfamily is involved in biological processes including growth, development and appetite sensing. MBOATs are attractive drug targets in cancer and obesity; however, information on the bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046e3682911cb037adf1cd5c1cfd25f8
https://doi.org/10.1002/ange.202014457
https://doi.org/10.1002/ange.202014457
Autor:
Claire E. Coupland, Sebastian A. Andrei, T. Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A. Schwab, Eamon F.X. Byrne, Els Pardon, Jan Steyaert, Anthony I. Magee, Thomas Lanyon-Hogg, Mark S.P. Sansom, Edward W. Tate, Christian Siebold
Publikováno v:
Molecular Cell
Summary The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4126d9db15243ce2d4d7d77c45ec15bc
https://pubmed.ncbi.nlm.nih.gov/34890564
https://pubmed.ncbi.nlm.nih.gov/34890564
Autor:
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D. Johnston, Claire E. Coupland, Sebastian A. Andrei, Joshua Newington, Anthony I. Magee, Christian Siebold, Edward W. Tate
The mammalian membrane-bound O-acyltransferase (MBOAT) superfamily is involved in biological processes including growth, development and appetite sensing. MBOATs are attractive drug targets in cancer and obesity; however, information on the binding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e59cf7fba46be40356dcde9c651c2d
http://hdl.handle.net/10044/1/87627
http://hdl.handle.net/10044/1/87627
Autor:
Antonios D Konitsiotis, Shu-Chun Chang, Biljana Jovanović, Paulina Ciepla, Naoko Masumoto, Christopher P Palmer, Edward W Tate, John R Couchman, Anthony I Magee
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89899 (2014)
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat
Externí odkaz:
https://doaj.org/article/8f7c265ca69d4979ad7a2c9a0cfe6987
Autor:
Anthony I. Magee, Nattawadee Panyain, Thomas Lanyon-Hogg, Markus Ritzefeld, Nicola O’Reilly, Ganka Bineva-Todd, Jasmine K. Bickel, Edward W. Tate, Cory A Ocasio, Lea Sefer, Christian Siebold, A.F. Rudolf
Publikováno v:
Chemical Science
A highly accurate and versatile fluorescence polarisation assay for any enzyme adding or removing lipid posttranslational modifications, with the potential to accelerate drug discovery against these targets.
Posttranslational attachment of lipid
Posttranslational attachment of lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac31b40b5b5d89fececdd949daee3aed
https://doi.org/10.1039/c9sc01785b
https://doi.org/10.1039/c9sc01785b
Autor:
Preiss, A.
Publikováno v:
Cell Biology International; March 1993, Vol. 17 Issue: 3 p359-360, 2p
Autor:
Emmanuelle Thinon, Ursula R. Rodgers, Antonio D. Konitsiotis, Anthony I. Magee, Naoko Masumoto, Edward W. Tate, George Bodakh, Raymond J. Owens, Thomas Lanyon-Hogg
Publikováno v:
Analytical Biochemistry
Hedgehog signaling is critical for correct embryogenesis and tissue development. However, on maturation, signaling is also found to be aberrantly activated in many cancers. Palmitoylation of the secreted signaling protein sonic hedgehog (Shh) by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deba21c0917231d911f1a22f0e2c2864
https://doi.org/10.1016/j.ab.2015.08.025
https://doi.org/10.1016/j.ab.2015.08.025