A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines

Autor: Christina Georgiou, Vassilis Kehayas, Kok Sin Lee, Federico Brandalise, Daniela A. Sahlender, Jerome Blanc, Graham Knott, Anthony Holtmaat

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)

Advanced light and electron microscopy identify a subset of cortical multipolar vasoactive intestinal peptide interneurons with high spine dynamics and characteristics that are greatly different from pyramidal neurons.

Externí odkaz: https://doaj.org/article/90f951de1d3f46638d787547d86353ef

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Autor: Laura Frangeul, Vassilis Kehayas, Jose V. Sanchez-Mut, Sabine Fièvre, K. Krishna-K, Gabrielle Pouchelon, Ludovic Telley, Camilla Bellone, Anthony Holtmaat, Johannes Gräff, Jeffrey D. Macklis, Denis Jabaudon

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Sensory input and neuronal activity are crucial for proper morphological development of neurons. Here, Frangeul and colleagues show that membrane excitability is a critical component of dendritic development in mouse somatosensory thalamocortical neu

Externí odkaz: https://doaj.org/article/df6df2febf084789bc9905068db29834

Circuit mechanisms for cortical plasticity and learning

Autor: Tanika Bawa, Leena E. Williams, Anthony Holtmaat, Ronan Chéreau

Publikováno v: Seminars in Cell & Developmental Biology. 125:68-75

The cerebral cortex integrates sensory information with emotional states and internal representations to produce coherent percepts, form associations, and execute voluntary actions. For the cortex to optimize perception, its neuronal network needs to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adbe4c5847de0a7ad05b127f10865f6
https://doi.org/10.1016/j.semcdb.2021.07.012

Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images

Autor: Rohan Gala, Daniel Lebrecht, Daniela A Sahlender, Anne Jorstad, Graham Knott, Anthony Holtmaat, Armen Stepanyants

Publikováno v: eLife, Vol 6 (2017)

The ability to measure minute structural changes in neural circuits is essential for long-term in vivo imaging studies. Here, we propose a methodology for detection and measurement of structural changes in axonal boutons imaged with time-lapse two-ph

Externí odkaz: https://doaj.org/article/d76350bb51054fe88fd6d680b1442136

A brain atlas of synapse protein lifetime across the mouse lifespan

Autor: Edita Bulovaite, Zhen Qiu, Maximilian Kratschke, Adrianna Zgraj, David G. Fricker, Eleanor J. Tuck, Ragini Gokhale, Babis Koniaris, Shekib A. Jami, Paula Merino-Serrais, Elodie Husi, Lorena Mendive-Tapia, Marc Vendrell, Thomas J. O’Dell, Javier DeFelipe, Noboru H. Komiyama, Anthony Holtmaat, Erik Fransén, Seth G.N. Grant

Publikováno v: Neuron
Bulovaite, E, Qiu, Z, Kratschke, M, Zgraj, A, Fricker, D G, Tuck, E J, Gokhale, R, Koniaris, B, Jami, S A, Merino-Serrais, P, Husi, E, Mendive-Tapia, L, Vendrell, M, O'Dell, T J, DeFelipe, J, Komiyama, N H, Holtmaat, A, Fransén, E & Grant, S G N 2022, ' A brain atlas of synapse protein lifetime across the mouse lifespan ', Neuron . https://doi.org/10.1016/j.neuron.2022.09.009

The lifetime of proteins in synapses is important for their signaling, maintenance, and remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an abundant postsynaptic protein in excitatory synapses, at single-synapse re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ab62ef318976a1b25f15c5b508a7f7
http://hdl.handle.net/10261/305259