Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anthony H. Schapira"'
Autor:
Melissa Leija-Salazar, Alan Pittman, Katya Mokretar, Huw Morris, Anthony H. Schapira, Christos Proukakis
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Somatic single nucleotide variant (SNV) mutations occur in neurons but their role in synucleinopathies is unknown.Aim: We aimed to identify disease-relevant low-level somatic SNVs in brains from sporadic patients with synucleinopathies an
Externí odkaz:
https://doaj.org/article/6cdfc4a8aaf24f0893c207d6c678e415
Autor:
Lydia Alvarez-Erviti, Yiqi Seow, Anthony H. Schapira, Chris Gardiner, Ian L. Sargent, Matthew J.A. Wood, J. Mark Cooper
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 360-367 (2011)
Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the
Externí odkaz:
https://doaj.org/article/79b853eac4d742388db9651233b23095
Autor:
Robert A. Hauser, Mark Forrest Gordon, Yoshikuni Mizuno, Werner Poewe, Paolo Barone, Anthony H. Schapira, Olivier Rascol, Catherine Debieuvre, Mandy Fräßdorf
Publikováno v:
Parkinson's Disease, Vol 2014 (2014)
Background. The minimal clinically important difference (MCID) is the smallest change in an outcome measure that is meaningful for patients. Objectives. To calculate the MCID for Unified Parkinson’s Disease Rating Scale (UPDRS) scores in early Park
Externí odkaz:
https://doaj.org/article/54d7f5bec96e4559aeda590d57da22b7
Autor:
Michael J. Devine, Alice Kaganovich, Mina Ryten, Adamantios Mamais, Daniah Trabzuni, Claudia Manzoni, Philip McGoldrick, Diane Chan, Allissa Dillman, Julia Zerle, Susannah Horan, Jan-Willem Taanman, John Hardy, Jose-Felix Marti-Masso, Daniel Healy, Anthony H. Schapira, Benjamin Wolozin, Rina Bandopadhyay, Mark R. Cookson, Marcel P. van der Brug, Patrick A. Lewis
Publikováno v:
PLoS ONE, Vol 7, Iss 1 (2012)
Externí odkaz:
https://doaj.org/article/46de591ce9b249fda4d5222348b06db5
Autor:
Yu, Yuan, Bethan S, Kilpatrick, Susanne, Gerndt, Franz, Bracher, Christian, Grimm, Anthony H, Schapira, Sandip, Patel
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Lysosomes are acidic Ca2+ stores often mobilised in conjunction with endoplasmic reticulum (ER) Ca2+ stores. Glycyl-L-phenylalanine 2-naphthylamide (GPN) is a widely used lysosomotropic agent that evokes cytosolic Ca2+ signals in many cells. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e16e82f8f7f70d115185f08bc903e694
https://pubmed.ncbi.nlm.nih.gov/33602742
https://pubmed.ncbi.nlm.nih.gov/33602742
Autor:
Leanne N, Hockey, Bethan S, Kilpatrick, Emily R, Eden, Yaping, Lin-Moshier, G Cristina, Brailoiu, Eugen, Brailoiu, Clare E, Futter, Anthony H, Schapira, Jonathan S, Marchant, Sandip, Patel
Publikováno v:
Journal of Cell Science
Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca2+ signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fe9dee7515ae61428bdaae79096295b
https://pubmed.ncbi.nlm.nih.gov/25416817
https://pubmed.ncbi.nlm.nih.gov/25416817
Autor:
Christos, Proukakis, Maryiam, Shoaee, James, Morris, Timothy, Brier, Eleanna, Kara, Una-Marie, Sheerin, Gavin, Charlesworth, Eduardo, Tolosa, Henry, Houlden, Nicholas W, Wood, Anthony H, Schapira
Publikováno v:
Movement Disorders
Background Although alpha-synuclein (SNCA) is crucial to the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB), mutations in the gene appear to be rare. We have recently hypothesized that somatic mutations in early developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ff63a6d3f36116b2dec995349ca511f
https://pubmed.ncbi.nlm.nih.gov/24752924
https://pubmed.ncbi.nlm.nih.gov/24752924
Autor:
Anthony H, Schapira, Peter, Jenner
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 26(6)
The past 25 years have seen a major expansion of knowledge concerning the cause of Parkinson's disease provided by an understanding of environmental and genetic factors that underlie the loss of nigral dopaminergic neurons. Based on the actions of to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60905fea3dec80ebb551004ad1975cd0
https://pubmed.ncbi.nlm.nih.gov/21626550
https://pubmed.ncbi.nlm.nih.gov/21626550
Autor:
Michael J, Devine, Alice, Kaganovich, Mina, Ryten, Adamantios, Mamais, Daniah, Trabzuni, Claudia, Manzoni, Philip, McGoldrick, Diane, Chan, Allissa, Dillman, Julia, Zerle, Susannah, Horan, Jan-Willem, Taanman, John, Hardy, Jose-Felix, Marti-Masso, Daniel, Healy, Daniel, Healey, Anthony H, Schapira, Benjamin, Wolozin, Rina, Bandopadhyay, Mark R, Cookson, Marcel P, van der Brug, Patrick A, Lewis
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22489 (2011)
PLoS ONE
PLoS ONE
Point mutations in LRRK2 cause autosomal dominant Parkinson's disease. Despite extensive efforts to determine the mechanism of cell death in patients with LRRK2 mutations, the aetiology of LRRK2 PD is not well understood. To examine possible alterati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c4e927403e5b1aad006a14c6e2d99d
https://centaur.reading.ac.uk/29465/1/LRRK2GWexpression.pdf
https://centaur.reading.ac.uk/29465/1/LRRK2GWexpression.pdf
Publikováno v:
Journal of neurochemistry. 96(5)
The neurotoxin MPTP induces nigral dopaminergic cell death in primates and produces a partial model of Parkinson's disease (PD). Pramipexole is a D2/D3 dopamine receptor agonist used in the symptomatic treatment of PD, and which also protects neurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91ec0bd4d94e66fe103284ac5df26b21
https://pubmed.ncbi.nlm.nih.gov/16464239
https://pubmed.ncbi.nlm.nih.gov/16464239