Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Anthony Griffiths"'
Autor:
Ariel S Wirchnianski, Elisabeth K Nyakatura, Andrew S Herbert, Ana I Kuehne, Shawn A Abbasi, Catalina Florez, Nadia Storm, Lindsay G A McKay, Leandrew Dailey, Erin Kuang, Dafna M Abelson, Anna Z Wec, Srinjoy Chakraborti, Frederick W Holtsberg, Sergey Shulenin, Zachary A Bornholdt, M Javad Aman, Anna N Honko, Anthony Griffiths, John M Dye, Kartik Chandran, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012134 (2024)
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance. Their activities can be furth
Externí odkaz:
https://doaj.org/article/2302156227ee41508fe68701e955e1ae
Autor:
Stephen J. Ross, Adam J. Hume, Judith Olejnik, Jacquelyn Turcinovic, Anna N. Honko, Lindsay G. A. McKay, John H. Connor, Anthony Griffiths, Elke Mühlberger, Daniel Cifuentes
Publikováno v:
Viruses, Vol 16, Iss 7, p 1064 (2024)
Although next-generation sequencing (NGS) has been instrumental in determining the genomic sequences of emerging RNA viruses, de novo sequence determination often lacks sufficient coverage of the 5′ and 3′ ends of the viral genomes. Since the gen
Externí odkaz:
https://doaj.org/article/af4be9266d694121958cb9c7fd2df16f
Autor:
Matthew R. Chang, Luke Tomasovic, Natalia A. Kuzmina, Adam J. Ronk, Patrick O. Byrne, Rebecca Johnson, Nadia Storm, Eduardo Olmedillas, Yixuan J. Hou, Alexandra Schäfer, Sarah R. Leist, Longping V. Tse, Hanzhong Ke, Christian Coherd, Katrina Nguyen, Maliwan Kamkaew, Anna Honko, Quan Zhu, Galit Alter, Erica Ollmann Saphire, Jason S. McLellan, Anthony Griffiths, Ralph S. Baric, Alexander Bukreyev, Wayne A. Marasco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
COVID-19 can be treated with monoclonal antibodies against SARS-CoV-2, but emerging new variants might show resistance towards existing therapy. Here authors show that anti-SARS-CoV-2 spike human single-chain antibody fragments could gain neutralizin
Externí odkaz:
https://doaj.org/article/d418ec52ee6b432581629e7a51ee58b4
Autor:
Brandon Carter, Pinghan Huang, Ge Liu, Yuejin Liang, Paulo J. C. Lin, Bi-Hung Peng, Lindsay G. A. McKay, Alexander Dimitrakakis, Jason Hsu, Vivian Tat, Panatda Saenkham-Huntsinger, Jinjin Chen, Clarety Kaseke, Gaurav D. Gaiha, Qiaobing Xu, Anthony Griffiths, Ying K. Tam, Chien-Te K. Tseng, David K. Gifford
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Licensed COVID-19 vaccines ameliorate viral infection by inducing production of neutralizing antibodies that bind the SARS-CoV-2 Spike protein and inhibit viral cellular entry. However, the clinical effectiveness of these vaccines is transitory as vi
Externí odkaz:
https://doaj.org/article/37d4703fe4c94f879a346594ee70e087
Autor:
Tammy C. T. Lan, Matty F. Allan, Lauren E. Malsick, Jia Z. Woo, Chi Zhu, Fengrui Zhang, Stuti Khandwala, Sherry S. Y. Nyeo, Yu Sun, Junjie U. Guo, Mark Bathe, Anders Näär, Anthony Griffiths, Silvi Rouskin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Lan et al. report RNA structure ensembles across the entire SARSCoV-2 genome in infected human cells at single nucleotide resolution. They find alternative RNA conformations critical for promoting near-native frameshifting rates in ORF1ab.
Externí odkaz:
https://doaj.org/article/a24301ced5994fcabcdc3524241e53c4
Autor:
Robert W. Cross, Ira M. Longini, Stephan Becker, Karin Bok, David Boucher, Miles W. Carroll, Janet V. Díaz, William E. Dowling, Ruxandra Draghia-Akli, James T. Duworko, John M. Dye, Michael A. Egan, Patricia Fast, Amy Finan, Courtney Finch, Thomas R. Fleming, Joan Fusco, Thomas W. Geisbert, Anthony Griffiths, Stephan Günther, Lisa E. Hensley, Anna Honko, Ruth Hunegnaw, Jocelyn Jakubik, Julie Ledgerwood, Kerstin Luhn, Demetrius Matassov, Jeffrey Meshulam, Emily V. Nelson, Christopher L. Parks, Roxana Rustomjee, David Safronetz, Lauren M. Schwartz, Dean Smith, Paul Smock, Ydrissa Sow, Christina F. Spiropoulou, Nancy J. Sullivan, Kelly L. Warfield, Daniel Wolfe, Courtney Woolsey, Roland Zahn, Ana María Henao-Restrepo, César Muñoz-Fontela, Andrea Marzi
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10 (2022)
The emergence of Marburg virus (MARV) in Guinea and Ghana triggered the assembly of the MARV vaccine “MARVAC” consortium representing leaders in the field of vaccine research and development aiming to facilitate a rapid response to this infectiou
Externí odkaz:
https://doaj.org/article/eb16d630ec60444cb74dc537f414a98d
Autor:
Nadia Storm, Lindsay G. A. McKay, Sierra N. Downs, Rebecca I. Johnson, Dagnachew Birru, Marc de Samber, Walter Willaert, Giovanni Cennini, Anthony Griffiths
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-5 (2020)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has devastated global public health systems and economies, with over 52 million people infected, millions of jobs and businesses lost, and more than 1 million deaths r
Externí odkaz:
https://doaj.org/article/777b21565801462a9a2bbe7e08aecb1c
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1505 (2022)
As demonstrated by the 2015 Zika virus outbreak in the Americas, emerging and re-emerging arboviruses are public health threats that warrant research investment for the development of effective prophylactics and therapeutics. Many arboviral diseases
Externí odkaz:
https://doaj.org/article/1ec8a532368b47bf844d1d30203231b2
Autor:
Thibault Colombani, Loek J. Eggermont, Zachary J. Rogers, Lindsay G. A. McKay, Laura E. Avena, Rebecca I. Johnson, Nadia Storm, Anthony Griffiths, Sidi A. Bencherif
Publikováno v:
Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has led to an unprecedented global health crisis, resulting in a critical need for effective vaccines that generate protective antibodies. Protein subunit vaccines represent a
Externí odkaz:
https://doaj.org/article/41d8a169b9674824a531554dd00e0e3f
Autor:
Kendra J. Alfson, Yenny Goez-Gazi, Michal Gazi, Ying-Liang Chou, Nancy A. Niemuth, Marc E. Mattix, Hilary Staples, Benjamin Klaffke, Gloria F. Rodriguez, Priscilla Escareno, Carmen Bartley, Anysha Ticer, Elizabeth A. Clemmons, John W. Dutton III, Anthony Griffiths, Gabe T. Meister, Daniel C. Sanford, Chris M. Cirimotich, Ricardo Carrion
Publikováno v:
Vaccines, Vol 10, Iss 10, p 1723 (2022)
The primary objective of this study was to characterize the disease course in cynomolgus macaques exposed to Sudan virus (SUDV), to determine if infection in this species is an appropriate model for the evaluation of filovirus countermeasures under t
Externí odkaz:
https://doaj.org/article/2cc1aa54e7954ee49dfdea798a0267ee