Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Anthony G. Zacchei"'
1
High-performance liquid chromatographic method for the determination of an HIV-1 non-nucleoside reverse transcriptase inhibitor (L-696,229) in plasma samples from animals
Autor: Ling L. Lee, Anthony G. Zacchei, Martha L. Herold
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 685:323-328
A sensitive high-performance liquid chromatographic (HPLC) method was developed and validated to separate and quantitate the levels of L-696,229 (I), a novel human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitor, and its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4517a3a55724352d16af7f25872ceb
https://doi.org/10.1016/s0378-4347(96)00172-7
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2
Enantioselective induction of peroxisomal proliferation in CD-1 mice by leukotriene antagonists
Autor: Robert Zamboni, Scott J. Grossman, Matthew J. Van Zwieten, John G. DeLuca, D.H. Patrick, Eugene G. Herold, Kevin P. Keenan, Anthony G. Zacchei
Publikováno v: Toxicology and Applied Pharmacology. 116:217-224
The effects of a racemic leukotriene antagonist (MK-0571) and its component enantiomers (L-668,018 and L-668,019) on hepatic peroxisome proliferation were examined in mice, rats, and rhesus monkeys. Administration of racemic MK-0571 to mice resulted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952216e3def837e9e9f0467da5f996d0
https://doi.org/10.1016/0041-008x(92)90301-8
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3
Thiobenzamide-induced hepatotoxicity: Effects of substituents and route of administration on the nature and extent of liver injury
Autor: John G. DeLuca, Douglas Kornbrust, Anthony G. Zacchei, Eugene G. Herold, Scott J. Grossman, D.H. Patrick, Peter F. Smith
Publikováno v: Toxicology and Applied Pharmacology. 111:388-408
Differences in the nature and extent of hepatic injury were examined after administration of para-substituted thiobenzamides to rats. In accordance with previous studies, the extent of hepatotoxicity varied with the electron-donating ability of the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25856d7c9d53e19ebe34261677bc61fe
https://doi.org/10.1016/0041-008x(91)90245-a
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4
Stereospecific HPLC method for the quantitation of the enantiomers of MK-0571, a potent leukotriene D4 receptor antagonist, in biological specimens
Autor: Anthony G. Zacchei, Ling L. Lee
Publikováno v: Chirality. 3:129-135
A stereospecific HPLC bioanalytical method was developed for quantitation of the enantiomers of MK-0571, a leukotriene D4 receptor antagonist. The procedure involves the addition of an internal standard analog to the biological matrix followed by ext
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615be9359c42f7f4dfc1ed87ef10ccd2
https://doi.org/10.1002/chir.530030209
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5
High-performance liquid chromatographic method for the determination of a novel leukotriene D4 antagonist (MK-0571) in biological specimens
Autor: Anthony G. Zacchei, Renee A. Berna
Publikováno v: Journal of chromatography. 563(2)
A rapid, sensitive and selective liquid chromatographic procedure was developed to quantitate the levels of a novel leukotriene D4 antagonist, MK-0571 (I), in biological samples. The method involves the addition of an internal standard, an analogue o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b1588c77095abaafe8225179ccd424
https://pubmed.ncbi.nlm.nih.gov/2056010
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6
Investigation of whisker-walled open tubular columns coated with manganese(II) chloride and cobalt(II) chloride
Autor: Robert L. Grob, Anthony G. Zacchei, Theodore I. Wishousky
Publikováno v: Journal of Chromatography A. 249:1-18
Whisker-walled open tubular columns were coated with either manganese(II)chloride or cobalt(II) chloride. These inorganic salt coated columns were employed to study the interaction of these sorbents with aromatic hydrocarbons that possessed varying
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5972391f4608e827d8944e228d832b28
https://doi.org/10.1016/s0021-9673(00)80228-9
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7
Electron-Capture GLC Determination of a New Antiarrhythmic Agent, α,α-Dimethyl-4-(α,α,β,β-tetrafluorophenethyl)benzylamine, in Biological Fluids
Autor: Anthony G. Zacchei, Linda Weidner
Publikováno v: Journal of Pharmaceutical Sciences. 64:814-818
A highly specific and sensitive GLC method was developed for the analysis of α,α-dimethyl-4-(α,α,β,β-tetrafluoro-phenethyl)benzylamine, a new orally active antiarrhythmic drug, in biological fluids. The procedure involves the addition of an int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f371c82731a90e22a9ee668fe7b3997
https://doi.org/10.1002/jps.2600640518
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10
A super active cyclic hexapeptide analog of somatostatin
Autor: William J. Paleveda, Roger M. Freidinger, Hoff Dale R, Ruth F. Nutt, L. D. Hall, Stephen F. Brady, Lawrence J. Mandarino, Hirschmann Ralph F, Dominick J. Tocco, Paul S. Anderson, Richard L. Vandlen, Anthony G. Zacchei, Richard Saperstein, Paul E. Curley, John E. Gerich, Debra S. Perlow, Eugene H. Cordes, Daniel F. Veber, C. Dylion Colton
Publikováno v: Life Sciences. 34:1371-1378
The cyclic hexapeptide, cyclo (Pro-Phe-D-Trp-Lys-Thr-Phe), I, has been shown to have the biological properties of somatostatin. We now report structure-activity studies which optimize the potency of this cyclic hexapeptide series with the synthesis o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05b2edee5fa33765cc9ea30ee754fe5
https://doi.org/10.1016/0024-3205(84)90009-2
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