Výsledky vyhledávání - "Anthony G, Lee"

Interfacial binding sites for cholesterol on GABAA receptors and competition with neurosteroids

Autor: Anthony G. Lee

Publikováno v: Biophysical Journal. 120:2710-2722

γ-Aminobutyric acid type A (GABAA) receptors in the brain are located in the outer membranes of brain cells where the concentration of cholesterol is high. Of the 25 available high-resolution structures available for GABAA receptors, none were deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bad4949a7db731bb9fc18d8e422a3a7
https://doi.org/10.1016/j.bpj.2021.05.009

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The role of cholesterol binding in the control of cholesterol by the Scap-Insig system

Autor: Anthony G. Lee

Publikováno v: European biophysics journal : EBJ. 51(4-5)

Scap and Insig, two proteins embedded in the membrane of the endoplasmic reticulum (ER), regulate the synthesis of cholesterol in animal cells by forming a dimer in the presence of high concentrations of cholesterol. Cryo-electron microscopic structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddbe07b021fbcd851d483a88141bbf0
https://pubmed.ncbi.nlm.nih.gov/35717507

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Interfacial Binding Sites for Cholesterol on Kir, Kv, K2P, and Related Potassium Channels

Autor: Anthony G. Lee

Publikováno v: Biophysical Journal. 119:35-47

Inwardly rectifying, voltage-gated, two-pore domain, and related K+ channels are located in eukaryotic membranes rich in cholesterol. Here, molecular docking is used to detect specific binding sites ("hot spots") for cholesterol on K+ channels with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7855fdf886a06caf932ee0e074e2743f
https://doi.org/10.1016/j.bpj.2020.05.028

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Interfacial binding sites for cholesterol on GABA

Autor: Anthony G, Lee

Publikováno v: Biophys J

γ-Aminobutyric acid type A (GABA(A)) receptors in the brain are located in the outer membranes of brain cells where the concentration of cholesterol is high. Of the 25 available high-resolution structures available for GABA(A) receptors, none were d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4dad8f1e20de999b6a1cbc8cc5762602
https://pubmed.ncbi.nlm.nih.gov/34022235

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Interfacial Binding Sites for Cholesterol on Kir, Kv, K

Autor: Anthony G, Lee

Publikováno v: Biophys J

Inwardly rectifying, voltage-gated, two-pore domain, and related K(+) channels are located in eukaryotic membranes rich in cholesterol. Here, molecular docking is used to detect specific binding sites (“hot spots”) for cholesterol on K(+) channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f4d507ff560a7513dd60a82ef48b3cc
https://pubmed.ncbi.nlm.nih.gov/32553129

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G protein coupled receptor interactions with cholesterol deep in the membrane

Autor: Samuel Genheden, Jonathan W. Essex, Anthony G. Lee

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:268-281

G-protein coupled receptors (GPCRs) are located in membranes rich in cholesterol. The membrane spanning surfaces of GPCRs contain exposed backbone carbonyl groups and residue side chains potentially capable of forming hydrogen bonds to cholesterol mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02a0366c72184e5f8348dab2d7f9a6e
https://doi.org/10.1016/j.bbamem.2016.12.001

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Interfacial Binding Sites for Cholesterol on TRP Ion Channels

Autor: Anthony G. Lee

Publikováno v: Biophys J

Transient receptor potential (TRP) channels are members of a large family of ion channels located in membranes rich in cholesterol, some of whose functions are affected by the cholesterol content of the membrane. Here, cholesterol binding to TRPs is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9790f29f67ef1d06745d27307f87736
https://pubmed.ncbi.nlm.nih.gov/31672270

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Interfacial Binding Sites for Cholesterol on G Protein-Coupled Receptors

Autor: Anthony G. Lee

Publikováno v: Biophys J

A docking procedure is described that allows the transmembrane surface of a G protein-coupled receptor (GPCR) to be swept rapidly for potential binding sites for cholesterol at the bilayer interfaces on the two sides of the membrane. The procedure ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a23783dbad4b7c500739b0957377072
https://pubmed.ncbi.nlm.nih.gov/31010663

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A Database of Predicted Binding Sites for Cholesterol on Membrane Proteins, Deep in the Membrane

Autor: Anthony G. Lee

Publikováno v: Biophysical journal. 115(3)

The outer membranes of animal cells contain high concentrations of cholesterol, of which a small proportion is located deep within the hydrophobic core of the membrane. An automated docking procedure is described that allows the characterization of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b9bde9b2a7d3609680e781c59f3655
https://pubmed.ncbi.nlm.nih.gov/30007584

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Characterizing the Fatty Acid Binding Site in the Cavity of Potassium Channel KcsA

Autor: Natalie P. Smithers, Anthony G. Lee, Juan H. Bolivar, J. Malcolm East

Publikováno v: Biochemistry

We show that interactions of fatty acids with the central cavity of potassium channel KcsA can be characterized using the fluorescence probe 11-dansylaminoundecanoic acid (Dauda). The fluorescence emission spectrum of Dauda bound to KcsA in bilayers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d4d3cbc7ef3b85532677814ec4b806
https://doi.org/10.1021/bi3009196

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