Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Anthony G, Hope"'
2
Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function
Autor: Sarah Martins da Silva, David W. Gray, Joanna Fraser, Sean G. Brown, Rachel C. McBrinn, Anthony G. Hope, Christopher L.R. Barratt
Publikováno v: British Journal of Pharmacology
Background and purpose Asthenozoospermia is a leading cause of male infertility, but development of pharmacological agents to improve sperm motility is hindered by the lack of effective screening platforms and knowledge of suitable molecular targets.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e174bd91283380fd79d7f3128f4ff7d4
http://europepmc.org/articles/PMC6932944
Zobrazit plný text záznamu
3
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Autor: Ivan Dikic, Rachel Toth, Sven M. Lange, Stephen P. Matthews, Isobel Cole, Paul G. Wyatt, Virginia Dee Cesare, Franz S. Gruber, Anthony G. Hope, Fraser Cunningham, Lee A. Armstrong, Denisa Bojkova, Yogesh Kulathu, Rukmini Mukherjee, Raja Sekhar Nirujogi, David W. Gray, Paul Davies, Jindrich Cinatl
Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0253364 (2021)
PLoS ONE
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large, multidomain, transmembrane protein, Nsp3 has been the most challenging Nsp to characterize. Encoded
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd32b1ded91543c9a2151942185c437
https://doaj.org/article/7e4e63d2ba344215bb01a64466ff2cc4
Zobrazit plný text záznamu
5
Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)
Autor: Lesley-Anne Pearson, David W. Gray, Rachel E. Heap, Anthony G. Hope, Kathleen M. S. E. Reyskens, C. James Hastie, J. Simon C. Arthur, Matthias Trost, Stuart P. McElroy, David W. Porter
Publikováno v: Slas Discovery
Matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF) mass spectrometry has become a promising alternative for high-throughput drug discovery as new instruments offer high speed, flexibility and sensitivity, and the ability to measur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e26650346a1cd45eb0c95de04f2b1e
https://pubmed.ncbi.nlm.nih.gov/28692323
Zobrazit plný text záznamu
6
Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem
Autor: Sarah J, Martins da Silva, Sean G, Brown, Keith, Sutton, Louise V, King, Halil, Ruso, David W, Gray, Paul G, Wyatt, Mark C, Kelly, Christopher L R, Barratt, Anthony G, Hope
Publikováno v: Human Reproduction (Oxford, England)
STUDY QUESTION Can pharma drug discovery approaches be utilized to transform investigation into novel therapeutics for male infertility? SUMMARY ANSWER High-throughput screening (HTS) is a viable approach to much-needed drug discovery for male factor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::086722e279ab81e3c83d8e5268457d83
https://pubmed.ncbi.nlm.nih.gov/28333338
Zobrazit plný text záznamu
7
Importance of the C-terminus of the human 5-HT3A receptor subunit
Autor: Amy S. Butler, Sarah Lindesay, Matthew D Kennedy, Nicholas M. Barnes, Anthony G Hope, Valerie B. Patchell, Barry A. Levine, Terri J. Dover
Publikováno v: Neuropharmacology. 56:292-302
Amongst the family members of Cys-loop LGICs, the atypical ability of the 5-HT3A subunit to form functional homomeric receptors allowed a direct investigation of the role of the C-terminus. Deletion of the three C-terminal amino acids (DeltaGln453-De
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a734d5da0f2fd3977a1ef4431a3b7d
https://doi.org/10.1016/j.neuropharm.2008.08.017
Zobrazit plný text záznamu
8
A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA
Autor: Lucile, Moynié, Anthony G, Hope, Kara, Finzel, Jason, Schmidberger, Stuart M, Leckie, Gunter, Schneider, Michael D, Burkart, Andrew D, Smith, David W, Gray, James H, Naismith
Publikováno v: Journal of Molecular Biology
Eukaryotes and prokaryotes possess fatty acid synthase (FAS) biosynthetic pathways that comprise iterative chain elongation, reduction, and dehydration reactions. The bacterial FASII pathway differs significantly from human FAS pathways and is a long
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56206f2cd6e8ba2b6e883a17de149aaf
https://pubmed.ncbi.nlm.nih.gov/26562505
Zobrazit plný text záznamu
9
Identification and importance of N-glycosylation of the human 5-hydroxytryptamine3A receptor subunit
Autor: Anthony G Hope, Julie M. Williams, Sarah A Monk, Nicholas M. Barnes
Publikováno v: Biochemical Pharmacology. 68:1787-1796
We investigated the presence and potential role of N-glycosylation of the human (h) 5-hydroxytryptamine3 (5-HT3A) receptor subunit expressed in COS-7 cells. Incubation of cells with the N-glycosylation inhibitor, tunicamycin, reduced the molecular we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77497428a18bb33065366b0d4e26b2a
https://doi.org/10.1016/j.bcp.2004.06.034
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje